2',4'-Dimethoxypropiophenone, also known as 2,4-dimethoxyphenyl propyl ketone, is a synthetic compound that has been studied for its potential therapeutic properties. It has been shown to possess antioxidant, anti-inflammatory, and neuroprotective effects in various experimental models. The compound is typically synthesized through a Friedel-Crafts acylation reaction using 1,3-dimethoxybenzene and propionyl chloride in the presence of a Lewis acid catalyst. Research into 2',4'-Dimethoxypropiophenone has focused on its potential as a treatment for neurodegenerative diseases, such as Parkinson's disease and Alzheimer's disease. The compound's ability to protect against oxidative stress and inflammation, as well as its interactions with key neurotransmitter systems, have made it a promising target for further investigation.'
| ID Source | ID |
|---|---|
| PubMed CID | 70020 |
| CHEBI ID | 167433 |
| SCHEMBL ID | 4653380 |
| Synonym |
|---|
| CHEBI:167433 |
| 1-(2,4-dimethoxyphenyl)propan-1-one |
| propiophenone, 2',4'-dimethoxy- |
| 1-propanone, 1-(2,4-dimethoxyphenyl)- |
| nsc34097 |
| 2',4'-dimethoxypropiophenone |
| nsc-34097 |
| 831-00-5 |
| IDI1_031024 |
| 2',4'-dimethoxypropiophenone, 97% |
| MAYBRIDGE4_000442 |
| SR-01000633098-1 |
| NCGC00177575-01 |
| HMS1522E02 |
| AKOS000296109 |
| BRD-K60578973-001-01-8 |
| 2'.4'-dimethoxypropiophenone |
| CCG-43153 |
| einecs 212-601-7 |
| nsc 34097 |
| FT-0610147 |
| DTXSID00232167 |
| SCHEMBL4653380 |
| MIAQBCIDZSELDU-UHFFFAOYSA-N |
| propan-1-one, 1-(2,4-dimethoxyphenyl)- |
| 1-(2,4-dimethoxyphenyl)-1-propanone # |
| 1-(2,4-dimethoxyphenyl)-1-propanone |
| CS-0204890 |
| 9EYJ6T4Z7D |
| N12069 |
| 2'4'-dimethoxypropiophenone 97 |
| BS-22832 |
| Class | Description |
|---|---|
| aromatic ketone | A ketone in which the carbonyl group is attached to an aromatic ring. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID588519 | A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities | 2011 | Antiviral research, Sep, Volume: 91, Issue:3 | High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors. |
| AID540299 | A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis | 2010 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21 | Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. |
| AID1159607 | Screen for inhibitors of RMI FANCM (MM2) intereaction | 2016 | Journal of biomolecular screening, Jul, Volume: 21, Issue:6 | A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway. |
| AID1794808 | Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL). | 2014 | Journal of biomolecular screening, Jul, Volume: 19, Issue:6 | A High-Throughput Assay to Identify Inhibitors of the Apicoplast DNA Polymerase from Plasmodium falciparum. |
| AID1794808 | Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL). | |||
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (80.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (13.13) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 5 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||