Page last updated: 2024-11-13
2-(hydroxymethyl)ethisterone
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Market Indicators
Description
2-(hydroxymethyl)ethisterone: RN given refers to (2alpha,17alpha)-isomer; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
| ID Source | ID |
|---|---|
| PubMed CID | 21123868 |
| CHEMBL ID | 3251827 |
| SCHEMBL ID | 7106647 |
| MeSH ID | M0145519 |
Synonyms (7)
| Synonym |
|---|
| 2-(hydroxymethyl)ethisterone |
| 2787-03-3 |
| 2alpha-(hydroxymethyl)ethisterone |
| pregn-4-en-20-yn-3-one, 17-hydroxy-2-(hydroxymethyl)-, (2alpha,17alpha)- |
| CHEMBL3251827 |
| SCHEMBL7106647 |
| (2s,8r,9s,10r,13s,14s,17r)-17-ethynyl-17-hydroxy-2-(hydroxymethyl)-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1h-cyclopenta[a]phenanthren-3-one |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Bioassays (6)
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1137007 | Drug metabolism in human assessed as metabolite level treated with 800 mg, po of danazol in urine after 24 hrs by TLC analysis | 1977 | Journal of medicinal chemistry, Mar, Volume: 20, Issue:3 | Isolation, synthesis, and biological activity of five metabolites of danazol. |
| AID1137010 | Inhibition of pituitary gonadotropin activity in rat assessed as decrease of testicular weight at 100 mg/kg, po for 14 days | 1977 | Journal of medicinal chemistry, Mar, Volume: 20, Issue:3 | Isolation, synthesis, and biological activity of five metabolites of danazol. |
| AID1137013 | Inhibition of pituitary gonadotropin activity in rat assessed as decrease of ovarian weight at 50 mg/kg, ip for 14 days | 1977 | Journal of medicinal chemistry, Mar, Volume: 20, Issue:3 | Isolation, synthesis, and biological activity of five metabolites of danazol. |
| AID1137009 | Inhibition of pituitary gonadotropin activity in rat assessed as decrease of seminal vesicles weight at 100 mg/kg, po for 14 days | 1977 | Journal of medicinal chemistry, Mar, Volume: 20, Issue:3 | Isolation, synthesis, and biological activity of five metabolites of danazol. |
| AID1137008 | Inhibition of pituitary gonadotropin activity in rat assessed as decrease of ventral prostate weight at 100 mg/kg, po for 14 days | 1977 | Journal of medicinal chemistry, Mar, Volume: 20, Issue:3 | Isolation, synthesis, and biological activity of five metabolites of danazol. |
| AID1137014 | Inhibition of pituitary gonadotropin activity in rat assessed as decrease of number of vaginal estrous days at 50 mg/kg, ip for 14 days | 1977 | Journal of medicinal chemistry, Mar, Volume: 20, Issue:3 | Isolation, synthesis, and biological activity of five metabolites of danazol. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
Research
Studies (5)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 4 (80.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
Market Indicators
Research Demand Index: 12.36
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.36) All Compounds (24.57) |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 1 (20.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 4 (80.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||