Page last updated: 2024-12-09

2-(4-hydroxy-1,3-thiazol-2-yl)-1-phenylethan-1-one

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

2-(4-hydroxy-1,3-thiazol-2-yl)-1-phenylethan-1-one is a **chemical compound** with the following structural features:

* **A thiazole ring**: A five-membered heterocyclic ring containing one sulfur atom and one nitrogen atom.
* **A hydroxyl group**: An -OH group attached to the thiazole ring.
* **A phenacyl group**: A phenyl ring attached to a carbonyl group (C=O) and a methylene group (CH2).

**Importance for Research**

This compound, or derivatives of it, have shown potential in various research areas:

* **Antimicrobial activity:** Studies have shown that some thiazole-containing compounds exhibit antimicrobial activity against bacteria and fungi. The hydroxyl group can contribute to this activity by increasing polarity and improving interactions with biological targets.
* **Anti-inflammatory activity:** Some thiazole derivatives have been investigated for their potential anti-inflammatory properties.
* **Cancer research:** Certain thiazole compounds have shown promising anticancer activity, particularly against tumor cell proliferation.
* **Neuroprotective effects:** Research has suggested that some thiazole compounds may have neuroprotective effects, potentially protecting against neuronal damage.

**It's important to note:**

* The specific activity and importance of 2-(4-hydroxy-1,3-thiazol-2-yl)-1-phenylethan-1-one itself may not be well-established. It is often a starting point for synthesizing other derivatives with enhanced activity.
* The specific mechanisms of action for these compounds are often complex and need further investigation.

**In summary:**

2-(4-hydroxy-1,3-thiazol-2-yl)-1-phenylethan-1-one is a promising chemical entity that has potential for research in various fields, including medicine, pharmaceuticals, and biotechnology. Further investigations are necessary to fully understand its properties and develop its applications.

Cross-References

ID SourceID
PubMed CID2799057
CHEBI ID170041
SCHEMBL ID7596461

Synonyms (13)

Synonym
CBMICRO_040456
CHEBI:170041
2-(4-hydroxy-1,3-thiazol-2-yl)-1-phenylethan-1-one
2-(4-hydroxy-1,3-thiazol-2-yl)-1-phenylethanone
BIM-0040396.P001
OPREA1_357200
SR-01000644928-1
HMS1661E06
CCG-55930
JOQQMFJVYDPJEK-UHFFFAOYSA-N
SCHEMBL7596461
cambridge id 5997318
BRD-K99676395-001-01-5
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
aromatic ketoneA ketone in which the carbonyl group is attached to an aromatic ring.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (6)

Assay IDTitleYearJournalArticle
AID588519A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities2011Antiviral research, Sep, Volume: 91, Issue:3
High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors.
AID540299A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis2010Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21
Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
AID1159607Screen for inhibitors of RMI FANCM (MM2) intereaction2016Journal of biomolecular screening, Jul, Volume: 21, Issue:6
A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway.
AID1794808Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL).2014Journal of biomolecular screening, Jul, Volume: 19, Issue:6
A High-Throughput Assay to Identify Inhibitors of the Apicoplast DNA Polymerase from Plasmodium falciparum.
AID1794808Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL).
AID1159537qHTS screening for TAG (triacylglycerol) accumulators in algae2017Plant physiology, Aug, Volume: 174, Issue:4
Identification and Metabolite Profiling of Chemical Activators of Lipid Accumulation in Green Algae.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's5 (83.33)24.3611
2020's1 (16.67)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 13.13

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index13.13 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index5.08 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (13.13)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]