Compounds > 2-(4-fluorophenylamino)-5-(2,4-dihydroxyphenyl)-1,3,4-thiadiazole
Page last updated: 2024-10-15

2-(4-fluorophenylamino)-5-(2,4-dihydroxyphenyl)-1,3,4-thiadiazole

Description

2-(4-fluorophenylamino)-5-(2,4-dihydroxyphenyl)-1,3,4-thiadiazole: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID135508389
CHEMBL ID397863
SCHEMBL ID6528904
MeSH IDM0510465

Synonyms (3)

Synonym
CHEMBL397863
SCHEMBL6528904
2-(4-fluorophenylamino)-5-(2,4-dihydroxyphenyl)-1,3,4-thiadiazole
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (43)

Assay IDTitleYearJournalArticle
AID678236Inhibition of ERK1/2 phosphorylation in human A549 cells assessed as peak effect time by Western blot analysis2012Bioorganic & medicinal chemistry letters, Sep-01, Volume: 22, Issue:17
2-Amino-1,3,4-thiadiazole derivative (FABT) inhibits the extracellular signal-regulated kinase pathway and induces cell cycle arrest in human non-small lung carcinoma cells.
AID678228Antiproliferative activity against human glioma cells2012Bioorganic & medicinal chemistry letters, Sep-01, Volume: 22, Issue:17
2-Amino-1,3,4-thiadiazole derivative (FABT) inhibits the extracellular signal-regulated kinase pathway and induces cell cycle arrest in human non-small lung carcinoma cells.
AID295145Antiproliferative activity against rat glioma C6 cells at 25 uM after 96 hrs by MTT assay2007Bioorganic & medicinal chemistry, May-01, Volume: 15, Issue:9
Anticancer, neuroprotective activities and computational studies of 2-amino-1,3,4-thiadiazole based compound.
AID678235Inhibition of ERK1/2 phosphorylation in human A549 cells after 24 hrs by Western blot analysis2012Bioorganic & medicinal chemistry letters, Sep-01, Volume: 22, Issue:17
2-Amino-1,3,4-thiadiazole derivative (FABT) inhibits the extracellular signal-regulated kinase pathway and induces cell cycle arrest in human non-small lung carcinoma cells.
AID678246Effect on p21Waf1/Cip1 protein expression in human A549 cells at 1 to 100 uM after 24 hrs by Western blot analysis2012Bioorganic & medicinal chemistry letters, Sep-01, Volume: 22, Issue:17
2-Amino-1,3,4-thiadiazole derivative (FABT) inhibits the extracellular signal-regulated kinase pathway and induces cell cycle arrest in human non-small lung carcinoma cells.
AID678254Cell cycle arrest in human A549 cells after 24 hrs by acridine orange staining-based flow cytometry2012Bioorganic & medicinal chemistry letters, Sep-01, Volume: 22, Issue:17
2-Amino-1,3,4-thiadiazole derivative (FABT) inhibits the extracellular signal-regulated kinase pathway and induces cell cycle arrest in human non-small lung carcinoma cells.
AID678248Cell cycle arrest in human A549 cells assessed as accumulation at G0/G1 phase at 10 uM after 24 hrs by acridine orange staining-based flow cytometry (Rvb =44.85 +/- 0.866 %)2012Bioorganic & medicinal chemistry letters, Sep-01, Volume: 22, Issue:17
2-Amino-1,3,4-thiadiazole derivative (FABT) inhibits the extracellular signal-regulated kinase pathway and induces cell cycle arrest in human non-small lung carcinoma cells.
AID678250Cell cycle arrest in human A549 cells assessed as accumulation at G0/G1 phase at 50 uM after 24 hrs by acridine orange staining-based flow cytometry (Rvb =44.85 +/- 0.866 %)2012Bioorganic & medicinal chemistry letters, Sep-01, Volume: 22, Issue:17
2-Amino-1,3,4-thiadiazole derivative (FABT) inhibits the extracellular signal-regulated kinase pathway and induces cell cycle arrest in human non-small lung carcinoma cells.
AID678230Antiproliferative activity against human lung adenocarcinoma cells2012Bioorganic & medicinal chemistry letters, Sep-01, Volume: 22, Issue:17
2-Amino-1,3,4-thiadiazole derivative (FABT) inhibits the extracellular signal-regulated kinase pathway and induces cell cycle arrest in human non-small lung carcinoma cells.
AID678238Inhibition of Rsk90 phosphorylation in human A549 cells after 24 hrs by Western blot analysis2012Bioorganic & medicinal chemistry letters, Sep-01, Volume: 22, Issue:17
2-Amino-1,3,4-thiadiazole derivative (FABT) inhibits the extracellular signal-regulated kinase pathway and induces cell cycle arrest in human non-small lung carcinoma cells.
AID678243Effect on ERK1 gene expression in human A549 cells at 5 to 25 uM after 24 hrs by RT-PCR analysis2012Bioorganic & medicinal chemistry letters, Sep-01, Volume: 22, Issue:17
2-Amino-1,3,4-thiadiazole derivative (FABT) inhibits the extracellular signal-regulated kinase pathway and induces cell cycle arrest in human non-small lung carcinoma cells.
AID678251Cell cycle arrest in human A549 cells assessed as accumulation at S phase at 10 uM after 24 hrs by acridine orange staining-based flow cytometry (Rvb =26.89 +/- 2.997 %)2012Bioorganic & medicinal chemistry letters, Sep-01, Volume: 22, Issue:17
2-Amino-1,3,4-thiadiazole derivative (FABT) inhibits the extracellular signal-regulated kinase pathway and induces cell cycle arrest in human non-small lung carcinoma cells.
AID678234Inhibition of ERK1/2 phosphorylation in human A549 cells at 25 uM by Western blot analysis2012Bioorganic & medicinal chemistry letters, Sep-01, Volume: 22, Issue:17
2-Amino-1,3,4-thiadiazole derivative (FABT) inhibits the extracellular signal-regulated kinase pathway and induces cell cycle arrest in human non-small lung carcinoma cells.
AID678237Inhibition of MEK1/2 phosphorylation in human A549 cells after 24 hrs by Western blot analysis2012Bioorganic & medicinal chemistry letters, Sep-01, Volume: 22, Issue:17
2-Amino-1,3,4-thiadiazole derivative (FABT) inhibits the extracellular signal-regulated kinase pathway and induces cell cycle arrest in human non-small lung carcinoma cells.
AID295144Antiproliferative activity against human SK-N-AS cells at 25 uM after 96 hrs by MTT assay2007Bioorganic & medicinal chemistry, May-01, Volume: 15, Issue:9
Anticancer, neuroprotective activities and computational studies of 2-amino-1,3,4-thiadiazole based compound.
AID678227Antiproliferative activity against human neuroblastoma cells2012Bioorganic & medicinal chemistry letters, Sep-01, Volume: 22, Issue:17
2-Amino-1,3,4-thiadiazole derivative (FABT) inhibits the extracellular signal-regulated kinase pathway and induces cell cycle arrest in human non-small lung carcinoma cells.
AID678232Antiproliferative activity against human hepatocytes2012Bioorganic & medicinal chemistry letters, Sep-01, Volume: 22, Issue:17
2-Amino-1,3,4-thiadiazole derivative (FABT) inhibits the extracellular signal-regulated kinase pathway and induces cell cycle arrest in human non-small lung carcinoma cells.
AID678226Antiproliferative activity against human medulloblastoma cells2012Bioorganic & medicinal chemistry letters, Sep-01, Volume: 22, Issue:17
2-Amino-1,3,4-thiadiazole derivative (FABT) inhibits the extracellular signal-regulated kinase pathway and induces cell cycle arrest in human non-small lung carcinoma cells.
AID678255Cell cycle arrest in human A549 cells assessed as accumulation at G2/M phase at 10 uM after 24 hrs by acridine orange staining-based flow cytometry (Rvb =16.66 +/- 0.622 %)2012Bioorganic & medicinal chemistry letters, Sep-01, Volume: 22, Issue:17
2-Amino-1,3,4-thiadiazole derivative (FABT) inhibits the extracellular signal-regulated kinase pathway and induces cell cycle arrest in human non-small lung carcinoma cells.
AID678252Cell cycle arrest in human A549 cells assessed as accumulation at S phase at 25 uM after 24 hrs by acridine orange staining-based flow cytometry (Rvb =26.89 +/- 2.997 %)2012Bioorganic & medicinal chemistry letters, Sep-01, Volume: 22, Issue:17
2-Amino-1,3,4-thiadiazole derivative (FABT) inhibits the extracellular signal-regulated kinase pathway and induces cell cycle arrest in human non-small lung carcinoma cells.
AID678233Antiproliferative activity against human skin fibroblast2012Bioorganic & medicinal chemistry letters, Sep-01, Volume: 22, Issue:17
2-Amino-1,3,4-thiadiazole derivative (FABT) inhibits the extracellular signal-regulated kinase pathway and induces cell cycle arrest in human non-small lung carcinoma cells.
AID295142Antiproliferative activity against human A549 cells at 10 uM after 96 hrs by MTT assay2007Bioorganic & medicinal chemistry, May-01, Volume: 15, Issue:9
Anticancer, neuroprotective activities and computational studies of 2-amino-1,3,4-thiadiazole based compound.
AID678249Cell cycle arrest in human A549 cells assessed as accumulation at G0/G1 phase at 25 uM after 24 hrs by acridine orange staining-based flow cytometry (Rvb =44.85 +/- 0.866 %)2012Bioorganic & medicinal chemistry letters, Sep-01, Volume: 22, Issue:17
2-Amino-1,3,4-thiadiazole derivative (FABT) inhibits the extracellular signal-regulated kinase pathway and induces cell cycle arrest in human non-small lung carcinoma cells.
AID295148Inhibition of rat glioma C6 cell migration at 5 uM after 24 hrs2007Bioorganic & medicinal chemistry, May-01, Volume: 15, Issue:9
Anticancer, neuroprotective activities and computational studies of 2-amino-1,3,4-thiadiazole based compound.
AID295149Neuroprotective activity against glutamate-induced neurotoxicity in rat cortical neurons2007Bioorganic & medicinal chemistry, May-01, Volume: 15, Issue:9
Anticancer, neuroprotective activities and computational studies of 2-amino-1,3,4-thiadiazole based compound.
AID678229Antiproliferative activity against human colon adenocarcinoma cells2012Bioorganic & medicinal chemistry letters, Sep-01, Volume: 22, Issue:17
2-Amino-1,3,4-thiadiazole derivative (FABT) inhibits the extracellular signal-regulated kinase pathway and induces cell cycle arrest in human non-small lung carcinoma cells.
AID295143Antiproliferative activity against human TE671 cells at 10 uM after 96 hrs by MTT assay2007Bioorganic & medicinal chemistry, May-01, Volume: 15, Issue:9
Anticancer, neuroprotective activities and computational studies of 2-amino-1,3,4-thiadiazole based compound.
AID678244Effect on CREB1 gene expression in human A549 cells at 5 to 25 uM after 24 hrs by RT-PCR analysis2012Bioorganic & medicinal chemistry letters, Sep-01, Volume: 22, Issue:17
2-Amino-1,3,4-thiadiazole derivative (FABT) inhibits the extracellular signal-regulated kinase pathway and induces cell cycle arrest in human non-small lung carcinoma cells.
AID678253Cell cycle arrest in human A549 cells assessed as accumulation at S phase at 50 uM after 24 hrs by acridine orange staining-based flow cytometry (Rvb =26.89 +/- 2.997 %)2012Bioorganic & medicinal chemistry letters, Sep-01, Volume: 22, Issue:17
2-Amino-1,3,4-thiadiazole derivative (FABT) inhibits the extracellular signal-regulated kinase pathway and induces cell cycle arrest in human non-small lung carcinoma cells.
AID678241Inhibition of PMA-stimulated ERK1/2 phosphorylation in human A549 cells after 24 hrs by Western blot analysis2012Bioorganic & medicinal chemistry letters, Sep-01, Volume: 22, Issue:17
2-Amino-1,3,4-thiadiazole derivative (FABT) inhibits the extracellular signal-regulated kinase pathway and induces cell cycle arrest in human non-small lung carcinoma cells.
AID295150Neuroprotective activity against serum deprivation induced neurotoxicity in rat cortical neurons2007Bioorganic & medicinal chemistry, May-01, Volume: 15, Issue:9
Anticancer, neuroprotective activities and computational studies of 2-amino-1,3,4-thiadiazole based compound.
AID295141Antiproliferative activity against human HT29 cells at 5 uM after 96 hrs by MTT assay2007Bioorganic & medicinal chemistry, May-01, Volume: 15, Issue:9
Anticancer, neuroprotective activities and computational studies of 2-amino-1,3,4-thiadiazole based compound.
AID295147Antiproliferative activity against rat glioma C6 cells assessed as decreased cell division after 48 hrs2007Bioorganic & medicinal chemistry, May-01, Volume: 15, Issue:9
Anticancer, neuroprotective activities and computational studies of 2-amino-1,3,4-thiadiazole based compound.
AID678240Effect on total ERK1/2 levels in human A549 cells by Western blot analysis2012Bioorganic & medicinal chemistry letters, Sep-01, Volume: 22, Issue:17
2-Amino-1,3,4-thiadiazole derivative (FABT) inhibits the extracellular signal-regulated kinase pathway and induces cell cycle arrest in human non-small lung carcinoma cells.
AID678245Effect on p27/Kip protein expression in human A549 cells at 1 to 100 uM after 24 hrs by Western blot analysis2012Bioorganic & medicinal chemistry letters, Sep-01, Volume: 22, Issue:17
2-Amino-1,3,4-thiadiazole derivative (FABT) inhibits the extracellular signal-regulated kinase pathway and induces cell cycle arrest in human non-small lung carcinoma cells.
AID678242Effect on total ERK1/2 levels in human A549 cells by Western blot analysis in presence of PMA2012Bioorganic & medicinal chemistry letters, Sep-01, Volume: 22, Issue:17
2-Amino-1,3,4-thiadiazole derivative (FABT) inhibits the extracellular signal-regulated kinase pathway and induces cell cycle arrest in human non-small lung carcinoma cells.
AID678225Antiproliferative activity against human rhabdomyosarcoma cells2012Bioorganic & medicinal chemistry letters, Sep-01, Volume: 22, Issue:17
2-Amino-1,3,4-thiadiazole derivative (FABT) inhibits the extracellular signal-regulated kinase pathway and induces cell cycle arrest in human non-small lung carcinoma cells.
AID678256Cell cycle arrest in human A549 cells assessed as accumulation at G2/M phase at 25 uM after 24 hrs by acridine orange staining-based flow cytometry (Rvb =16.66 +/- 0.622 %)2012Bioorganic & medicinal chemistry letters, Sep-01, Volume: 22, Issue:17
2-Amino-1,3,4-thiadiazole derivative (FABT) inhibits the extracellular signal-regulated kinase pathway and induces cell cycle arrest in human non-small lung carcinoma cells.
AID295146Antiproliferative activity against human A549 cells assessed as decreased cell division after 48 hrs2007Bioorganic & medicinal chemistry, May-01, Volume: 15, Issue:9
Anticancer, neuroprotective activities and computational studies of 2-amino-1,3,4-thiadiazole based compound.
AID678247Effect on cyclinD1 protein expression in human A549 cells at 1 to 100 uM after 24 hrs by Western blot analysis2012Bioorganic & medicinal chemistry letters, Sep-01, Volume: 22, Issue:17
2-Amino-1,3,4-thiadiazole derivative (FABT) inhibits the extracellular signal-regulated kinase pathway and induces cell cycle arrest in human non-small lung carcinoma cells.
AID678239Inhibition of CREB phosphorylation in human A549 cells after 24 hrs by Western blot analysis2012Bioorganic & medicinal chemistry letters, Sep-01, Volume: 22, Issue:17
2-Amino-1,3,4-thiadiazole derivative (FABT) inhibits the extracellular signal-regulated kinase pathway and induces cell cycle arrest in human non-small lung carcinoma cells.
AID678257Cell cycle arrest in human A549 cells assessed as accumulation at G2/M phase at 50 uM after 24 hrs by acridine orange staining-based flow cytometry (Rvb =16.66 +/- 0.622 %)2012Bioorganic & medicinal chemistry letters, Sep-01, Volume: 22, Issue:17
2-Amino-1,3,4-thiadiazole derivative (FABT) inhibits the extracellular signal-regulated kinase pathway and induces cell cycle arrest in human non-small lung carcinoma cells.
AID678231Antiproliferative activity against human astrocytes2012Bioorganic & medicinal chemistry letters, Sep-01, Volume: 22, Issue:17
2-Amino-1,3,4-thiadiazole derivative (FABT) inhibits the extracellular signal-regulated kinase pathway and induces cell cycle arrest in human non-small lung carcinoma cells.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (20.00)29.6817
2010's4 (80.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
1,2-dipalmitoylphosphatidylcholine
1,2-Dipalmitoylphosphatidylcholine: Synthetic phospholipid used in liposomes and lipid bilayers to study biological membranes. It is also a major constituent of PULMONARY SURFACTANTS.		2.0710
thiazoles
[no description available]		2.98401,3-thiazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene
2-amino-1,3,4-thiadiazole
2-amino-1,3,4-thiadiazole: structure; RN given refers to parent cpd		2.0310
ConditionIndicatedRelationship StrengthStudiesTrials
Sensitivity and Specificity
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)		02.0310
Carcinoma, Non-Small Cell Lung
[description not available]		02.0710
Cancer of Lung
[description not available]		02.0710
Carcinoma, Non-Small-Cell Lung
A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.		02.0710
Lung Neoplasms
Tumors or cancer of the LUNG.		02.0710