Page last updated: 2024-12-05

2-(4-fluorophenyl)acetic acid

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

2-(4-Fluorophenyl)acetic acid, also known as 4-fluoro-phenylacetic acid, is a synthetic organic compound that has been studied for its potential pharmacological properties. It is an analogue of phenylacetic acid, with a fluorine atom substituted at the para position of the phenyl ring. The compound has been shown to exhibit various biological activities, including anti-inflammatory, analgesic, and anticonvulsant effects. It has also been investigated for its potential use in treating conditions such as cancer and Alzheimer's disease. The synthesis of 2-(4-fluorophenyl)acetic acid typically involves the reaction of 4-fluorophenylacetonitrile with a strong acid, such as hydrochloric acid, followed by hydrolysis. The compound's importance stems from its unique chemical structure and its ability to interact with various biological targets. Research on 2-(4-fluorophenyl)acetic acid focuses on understanding its mechanisms of action, exploring its therapeutic potential, and optimizing its chemical properties for drug development. '

2-(4-fluorophenyl)acetic acid: a positron emitting tumor imaging agent; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID9837
SCHEMBL ID104746
MeSH IDM0425162

Synonyms (54)

Synonym
STK499017
p-fluorophenylacetic acid
ba 2821
405-50-5
acetic acid, (p-fluorophenyl)-
nsc-402
(p-fluorophenyl)acetic acid
benzeneacetic acid, 4-fluoro-
(4-fluorophenyl)acetic acid
nsc402
4-fluorophenylacetic acid, 98%
4-fluorophenylacetic acid
MAYBRIDGE1_006666
AC-10975
HMS560G22
2-(4-fluorophenyl)acetic acid
mgkpfalcndrsqd-uhfffaoysa-
inchi=1/c8h7fo2/c9-7-3-1-6(2-4-7)5-8(10)11/h1-4h,5h2,(h,10,11)
F0206
AKOS000119591
AH-034/32462009
unii-s5yjv7caz1
nsc 402
s5yjv7caz1 ,
ai3-52627
einecs 206-972-4
A825162
2-(4-fluorophenyl)-acetic acid
BP-20574
FT-0601465
AM20060020
SCHEMBL104746
BH-0409
p-fluorophenylacetic acid [mi]
fluorophenylacetic acid, p-
4-fluorobenzeneacetic acid
(4-fluoro-phenyl)-acetic acid
4-fluoro phenylacetic acid
p-fluorophenyl acetic acid
4-fluorophenyl-acetic acid
4-fluoro phenyl acetic acid
4-fluorophenyl acetic acid
4-fluoro-phenyl-acetic acid
DTXSID0059956
W-106345
mfcd00004343
F2191-0056
CS-W001955
SY001347
Q27288702
n-boc-(r)-2-amino-3-hydroxy-3-methylbutanoicacid
EN300-20216
PD119085
Z104477312
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (1)

Assay IDTitleYearJournalArticle
AID1159607Screen for inhibitors of RMI FANCM (MM2) intereaction2016Journal of biomolecular screening, Jul, Volume: 21, Issue:6
A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (50.00)29.6817
2010's2 (33.33)24.3611
2020's1 (16.67)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.64

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.64 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.59 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.64)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]