Compounds > 2-(4-fluorophenyl)acetic acid
Page last updated: 2024-12-05

2-(4-fluorophenyl)acetic acid

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

2-(4-Fluorophenyl)acetic acid, also known as 4-fluoro-phenylacetic acid, is a synthetic organic compound that has been studied for its potential pharmacological properties. It is an analogue of phenylacetic acid, with a fluorine atom substituted at the para position of the phenyl ring. The compound has been shown to exhibit various biological activities, including anti-inflammatory, analgesic, and anticonvulsant effects. It has also been investigated for its potential use in treating conditions such as cancer and Alzheimer's disease. The synthesis of 2-(4-fluorophenyl)acetic acid typically involves the reaction of 4-fluorophenylacetonitrile with a strong acid, such as hydrochloric acid, followed by hydrolysis. The compound's importance stems from its unique chemical structure and its ability to interact with various biological targets. Research on 2-(4-fluorophenyl)acetic acid focuses on understanding its mechanisms of action, exploring its therapeutic potential, and optimizing its chemical properties for drug development. '

2-(4-fluorophenyl)acetic acid: a positron emitting tumor imaging agent; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID9837
SCHEMBL ID104746
MeSH IDM0425162

Synonyms (54)

Synonym
STK499017
p-fluorophenylacetic acid
ba 2821
405-50-5
acetic acid, (p-fluorophenyl)-
nsc-402
(p-fluorophenyl)acetic acid
benzeneacetic acid, 4-fluoro-
(4-fluorophenyl)acetic acid
nsc402
4-fluorophenylacetic acid, 98%
4-fluorophenylacetic acid
MAYBRIDGE1_006666
AC-10975
HMS560G22
2-(4-fluorophenyl)acetic acid
mgkpfalcndrsqd-uhfffaoysa-
inchi=1/c8h7fo2/c9-7-3-1-6(2-4-7)5-8(10)11/h1-4h,5h2,(h,10,11)
F0206
AKOS000119591
AH-034/32462009
unii-s5yjv7caz1
nsc 402
s5yjv7caz1 ,
ai3-52627
einecs 206-972-4
A825162
2-(4-fluorophenyl)-acetic acid
BP-20574
FT-0601465
AM20060020
SCHEMBL104746
BH-0409
p-fluorophenylacetic acid [mi]
fluorophenylacetic acid, p-
4-fluorobenzeneacetic acid
(4-fluoro-phenyl)-acetic acid
4-fluoro phenylacetic acid
p-fluorophenyl acetic acid
4-fluorophenyl-acetic acid
4-fluoro phenyl acetic acid
4-fluorophenyl acetic acid
4-fluoro-phenyl-acetic acid
DTXSID0059956
W-106345
mfcd00004343
F2191-0056
CS-W001955
SY001347
Q27288702
n-boc-(r)-2-amino-3-hydroxy-3-methylbutanoicacid
EN300-20216
PD119085
Z104477312
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (1)

Assay IDTitleYearJournalArticle
AID1159607Screen for inhibitors of RMI FANCM (MM2) intereaction2016Journal of biomolecular screening, Jul, Volume: 21, Issue:6
A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (50.00)29.6817
2010's2 (33.33)24.3611
2020's1 (16.67)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.64

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.64 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.59 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.64)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
hydrogen
Hydrogen: The first chemical element in the periodic table with atomic symbol H, and atomic number 1. Protium (atomic weight 1) is by far the most common hydrogen isotope. Hydrogen also exists as the stable isotope DEUTERIUM (atomic weight 2) and the radioactive isotope TRITIUM (atomic weight 3). Hydrogen forms into a diatomic molecule at room temperature and appears as a highly flammable colorless and odorless gas.. dihydrogen : An elemental molecule consisting of two hydrogens joined by a single bond.		2.0310elemental hydrogen;
elemental molecule;
gas molecular entity		antioxidant;
electron donor;
food packaging gas;
fuel;
human metabolite
phenylacetic acid
phenylacetic acid : A monocarboxylic acid that is toluene in which one of the hydrogens of the methyl group has been replaced by a carboxy group.		2.0110benzenes;
monocarboxylic acid;
phenylacetic acids		allergen;
Aspergillus metabolite;
auxin;
EC 6.4.1.1 (pyruvate carboxylase) inhibitor;
Escherichia coli metabolite;
human metabolite;
plant growth retardant;
plant metabolite;
Saccharomyces cerevisiae metabolite;
toxin
styrene
Styrene: A colorless, toxic liquid with a strong aromatic odor. It is used to make rubbers, polymers and copolymers, and polystyrene plastics.. styrene : A vinylarene that is benzene carrying a vinyl group. It has been isolated from the benzoin resin produced by Styrax species.		2.0310styrenes;
vinylarene;
volatile organic compound		mouse metabolite;
mutagen;
plant metabolite
platinum
Platinum: A heavy, soft, whitish metal, resembling tin, with atomic number 78, atomic weight 195.084, symbol Pt. It is used in manufacturing equipment for laboratory and industrial use. It occurs as a black powder (platinum black) and as a spongy substance (spongy platinum) and may have been known in Pliny's time as alutiae.		2.4110elemental platinum;
nickel group element atom;
platinum group metal atom
phenyl acetate
phenyl acetate: The ester formed between phenol and acetic acid. Don't confuse with phenylacetic acid derivatives listed under PHENYLACETATES.. phenyl acetate : An acetate ester obtained by the formal condensation of phenol with acetic acid.		2.0110benzenes;
phenyl acetates
ConditionIndicatedRelationship StrengthStudiesTrials
Anemia, Fanconi
[description not available]		02.1310
Fanconi Anemia
Congenital disorder affecting all bone marrow elements, resulting in ANEMIA; LEUKOPENIA; and THROMBOPENIA, and associated with cardiac, renal, and limb malformations as well as dermal pigmentary changes. Spontaneous CHROMOSOME BREAKAGE is a feature of this disease along with predisposition to LEUKEMIA. There are at least 7 complementation groups in Fanconi anemia: FANCA, FANCB, FANCC, FANCD1, FANCD2, FANCE, FANCF, FANCG, and FANCL. (from Online Mendelian Inheritance in Man, http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=227650, August 20, 2004)		02.1310
Astrocytoma, Grade IV
[description not available]		02.4110
Cancer of Ovary
[description not available]		02.4110
Glioblastoma
A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.		02.4110
Ovarian Neoplasms
Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.		02.4110
Glial Cell Tumors
[description not available]		02.0110
Experimental Mammary Neoplasms
[description not available]		02.0110
Glioma
Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)		02.0110