Compounds > 2-(4-fluoro-3-(trifluoromethyl)phenoxy)-n-(phenylmethyl)butanamide
Page last updated: 2024-11-11

2-(4-fluoro-3-(trifluoromethyl)phenoxy)-n-(phenylmethyl)butanamide

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

2-(4-fluoro-3-(trifluoromethyl)phenoxy)-N-(phenylmethyl)butanamide: inhibits phytoene-desaturase; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

beflubutamid : A racemate comprising equimolar amounts of (R)- and (S)-beflubutamid. An inhibitor of carotenoid biosynthesis, it is used for the pre- and early post-emergence control of broad-leaved weeds in a variety of cereal crops. The (-)-enantiomer has at least 1000 times higher herbicidal activity than the (+)-enantiomer. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

N-benzyl-2-[4-fluoro-3-(trifluoromethyl)phenoxy]butanamide : A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of 2-[4-fluoro-3-(trifluoromethyl)phenoxy]butyric acid with the amino group of benzylamine. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID6451159
CHEBI ID138203
SCHEMBL ID115747
MeSH IDM0593611

Synonyms (27)

Synonym
beflubutamid
CHEBI:138203
n-benzyl-2-[4-fluoro-3-(trifluoromethyl)phenoxy]butanamide
n-benzyl-2-[4-fluoro-3-(trifluoromethyl)phenoxy]butyramide
beflubutamid [iso]
(rs)-n-benzyl-2-(alpha,alpha,alpha,4-tetrafluoro-m-tolyloxy)butyramide
113614-08-7
unii-yw9853iq3u
yw9853iq3u ,
2-[4-fluoro-3-(trifluoromethyl)phenoxy]-n-(phenylmethyl)butanamide
SCHEMBL115747
DTXSID7057941
n-benzyl-2-(4-fluoro-3-trifluoromethylphenoxy)butanoic amide
2-(4-fluoro-3-(trifluoromethyl)phenoxy)-n-(phenylmethyl)butanamide
butanamide, 2-(4-fluoro-3-(trifluoromethyl)phenoxy)-n-(phenylmethyl)-
beflubutamid, (+/-)-
benfluamid
ubh-820
ubh 820
beflubutamid, pestanal(r), analytical standard
Z3301415053
beflubutamid 100 microg/ml in acetonitrile
n-benzyl-2-(4-fluoro-3-(trifluoromethyl)phenoxy)butanamide
Q22712766
c18h17f4no2
butanamide, 2-[4-fluoro-3-(trifluoromethyl)phenoxy]-n-(phenylmethyl)-
AKOS040744438

Research Excerpts

Dosage Studied

ExcerptRelevanceReference
"In field experiments, assessment of herbicide selectivity and efficacy rarely takes advantage of dose-response regressions."( Assessing herbicide symptoms by using a logarithmic field sprayer.
Andreasen, C; Cunha, BRD; Nielsen, J; Rasmussen, J; Ritz, C; Streibig, JC, 2019)		0.51
"Suitable nonlinear regression models are now available for fitting dose-response data from a logarithmic sprayer in field experiments."( Assessing herbicide symptoms by using a logarithmic field sprayer.
Andreasen, C; Cunha, BRD; Nielsen, J; Rasmussen, J; Ritz, C; Streibig, JC, 2019)		0.51
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (4)

ClassDescription
monocarboxylic acid amideA carboxamide derived from a monocarboxylic acid.
aromatic etherAny ether in which the oxygen is attached to at least one aryl substituent.
monofluorobenzenesAny member of the class of fluorobenzenes containing a mono- or poly-substituted benzene ring carrying a single fluorine substitutent.
(trifluoromethyl)benzenesAn organofluorine compound that is (trifluoromethyl)benzene and derivatives arising from substitution of one or more of the phenyl hydrogens.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (16.67)29.6817
2010's4 (66.67)24.3611
2020's1 (16.67)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 13.18

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index13.18 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index5.12 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (13.18)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
niacinamide
nicotinamide : A pyridinecarboxamide that is pyridine in which the hydrogen at position 3 is replaced by a carboxamide group.		2.2110pyridine alkaloid;
pyridinecarboxamide;
vitamin B3		anti-inflammatory agent;
antioxidant;
cofactor;
EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor;
EC 3.5.1.98 (histone deacetylase) inhibitor;
Escherichia coli metabolite;
geroprotector;
human urinary metabolite;
metabolite;
mouse metabolite;
neuroprotective agent;
Saccharomyces cerevisiae metabolite;
Sir2 inhibitor
diphenylamine
Diphenylamine: In humans it may be irritating to mucous membranes. Methemoglobinemia has been produced experimentally. In veterinary use, it is one of active ingredients in topical agents for prevention and treatment of screwworm infestation. An indicator in tests for nitrate poisoning.. diphenylamine : An aromatic amine containing two phenyl substituents. It has been used as a fungicide for the treatment of superficial scald in apples and pears, but is no longer approved for this purpose within the European Union.		2.610aromatic amine;
bridged diphenyl fungicide;
secondary amino compound		antifungal agrochemical;
antioxidant;
carotogenesis inhibitor;
EC 1.3.99.29 [phytoene desaturase (zeta-carotene-forming)] inhibitor;
ferroptosis inhibitor;
radical scavenger
norflurazone
norflurazone: structure. norflurazon : A pyridazinone that is pyridazin-3(2H)-one which is substituted at positions 2, 4, and 5 by m-(trifluoromethyl)phenyl, chloro, and methylamino groups, respectively. A pre-emergence herbicide used to control grasses and broad-leafed weeds in a variety of crops. Not approved for use within the European Union.		2.110(trifluoromethyl)benzenes;
organochlorine compound;
pyridazinone;
secondary amino compound		agrochemical;
carotenoid biosynthesis inhibitor;
herbicide
diflufenican
diflufenican : A pyridinecarboxamide that is pyridine-3-carboxamide substituted by a 2,4-difluorophenyl group at the carbamoyl nitrogen and a 3-(trifluoromethyl)phenoxy group at position 2.		2.2110(trifluoromethyl)benzenes;
aromatic ether;
pyridinecarboxamide		carotenoid biosynthesis inhibitor;
environmental contaminant;
herbicide;
xenobiotic
flavin-adenine dinucleotide
Flavin-Adenine Dinucleotide: A condensation product of riboflavin and adenosine diphosphate. The coenzyme of various aerobic dehydrogenases, e.g., D-amino acid oxidase and L-amino acid oxidase. (Lehninger, Principles of Biochemistry, 1982, p972)		2.110flavin adenine dinucleotide;
vitamin B2		cofactor;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
prosthetic group
chlorophyll a
Chlorophyll: Porphyrin derivatives containing magnesium that act to convert light energy in photosynthetic organisms.. chlorophyll : A family of magnesium porphyrins, defined by the presence of a fifth ring beyond the four pyrrole-like rings. The rings can have various side chains which usually include a long phytol chain.		2.0810chlorophyll;
methyl ester		cofactor
pheophytin a
pheophytin a: structure given in first source; RN given refers to (3S-(3alpha(2E,7S*,11S*),4beta,21beta))-isomer		2.0810
ConditionIndicatedRelationship StrengthStudiesTrials