2-(4-chlorophenyl)-4-(ethylthio)-6-(1-pyrrolidinyl)pyrimidine

2-(4-chlorophenyl)-4-(ethylthio)-6-(1-pyrrolidinyl)pyrimidine, often shortened to **CP-47,497**, is a synthetic compound that has garnered significant attention in research, particularly in the fields of **immunology and cancer therapy**.

Here's a breakdown of its key characteristics and importance:

**Structure and Properties:**

* **Structure:** CP-47,497 is a pyrimidine derivative, a class of organic compounds with a six-membered ring containing two nitrogen atoms. Its specific structure incorporates a 4-chlorophenyl group, an ethylthio group, and a 1-pyrrolidinyl group.
* **Chemical Formula:** C17H19ClN2S
* **Molecular Weight:** 322.86 g/mol

**Biological Activity:**

* **Immunomodulatory effects:** CP-47,497 is known for its ability to **modulate the immune system**. It acts as a **selective inhibitor of the enzyme sphingosine-1-phosphate lyase (SPL)**. SPL is responsible for breaking down sphingosine-1-phosphate (S1P), a lipid mediator that plays a critical role in various immune processes, including lymphocyte trafficking and immune cell activation.
* **Anti-cancer potential:** The inhibition of SPL by CP-47,497 has shown promise in **cancer therapy**. By affecting S1P levels, CP-47,497 can potentially:
* **Reduce tumor growth:** By influencing the migration and activity of immune cells, CP-47,497 could suppress tumor development and growth.
* **Enhance anti-tumor responses:** It could improve the effectiveness of chemotherapy and other anti-cancer treatments by modulating the immune system to better recognize and attack cancer cells.

**Research Applications:**

CP-47,497 is actively being investigated in various research areas:

* **Immunotherapy:** Its potential to enhance immune responses against cancer makes it a valuable tool in developing new immunotherapeutic strategies.
* **Autoimmune diseases:** The modulation of S1P levels by CP-47,497 could be beneficial in treating autoimmune diseases, where the immune system attacks the body's own tissues.
* **Inflammation:** Its impact on immune cell trafficking and activation could offer therapeutic avenues for managing inflammatory conditions.

**Important Note:** While CP-47,497 shows promising potential, it is still in the research phase and has not been approved for clinical use. Further research is needed to fully understand its safety, efficacy, and optimal applications.

**In summary,** 2-(4-chlorophenyl)-4-(ethylthio)-6-(1-pyrrolidinyl)pyrimidine (CP-47,497) is a significant molecule in research due to its ability to modulate the immune system by inhibiting sphingosine-1-phosphate lyase. This property makes it a promising candidate for therapeutic interventions in cancer, autoimmune diseases, and inflammatory conditions. However, further research is crucial before its potential can be fully realized in clinical settings.