Page last updated: 2024-12-09

2-(3-acetyl-1-indolyl)-N-(2,4-dimethylphenyl)acetamide

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

You're asking about a specific chemical compound, **2-(3-acetyl-1-indolyl)-N-(2,4-dimethylphenyl)acetamide**. This compound doesn't have a widely recognized name or a readily available research history.

Let's break down the components and why it *could* be of interest to research:

**Components of the Compound:**

* **Indole:** A core structure found in many biologically active compounds, including the neurotransmitter serotonin.
* **Acetyl:** A common functional group involved in various biochemical reactions.
* **Acetamide:** Another common functional group often found in pharmaceuticals.
* **2,4-dimethylphenyl:** A substituted phenyl ring, which can influence a molecule's properties.

**Possible Research Relevance:**

* **Pharmaceutical Development:** The combination of these components suggests that this compound could have potential pharmacological activity. Indole-based compounds are often explored for their impact on the central nervous system, while acetamide groups are frequently found in pain relievers and anti-inflammatory drugs.
* **Biological Activity:** This compound might interact with specific enzymes or receptors in the body. It could have effects on cell signaling, neurotransmission, or even influence the development of new drugs.

**Why it's Difficult to Find Research:**

* **New Compound:** This specific compound might be newly synthesized. It could be part of a research project currently underway, and the results might not be publicly available yet.
* **Limited Research:** Even if it's been studied, it might have shown limited activity or undesirable side effects, making it less attractive for further investigation.

**Finding More Information:**

To learn more, you would need to do the following:

1. **Check Chemical Databases:** Search for the compound's name or structure in chemical databases like PubChem, SciFinder, or Reaxys.
2. **Search Scientific Literature:** Use search engines like Google Scholar or PubMed with keywords like 2-(3-acetyl-1-indolyl)-N-(2,4-dimethylphenyl)acetamide or related terms like indole derivatives or acetamide derivatives.
3. **Contact Research Groups:** If you find research papers related to this compound or similar structures, you can try to contact the researchers involved directly.

Remember that scientific research takes time, and not all compounds are extensively studied. It's possible this compound might be a promising lead for future research, but it's also possible it might not be of major interest due to lack of activity or other factors.

Cross-References

ID SourceID
PubMed CID1088499
CHEMBL ID1453704
CHEBI ID113121

Synonyms (14)

Synonym
MLS000528237 ,
smr000120812
2-(3-acetyl-indol-1-yl)-n-(2,4-dimethyl-phenyl)-acetamide
CHEBI:113121
AKOS000465391
2-(3-acetylindol-1-yl)-n-(2,4-dimethylphenyl)acetamide
HMS2177J22
STL431616
2-(3-acetyl-1h-indol-1-yl)-n-(2,4-dimethylphenyl)acetamide
CHEMBL1453704
SR-01000365593-1
sr-01000365593
2-(3-acetyl-1-indolyl)-n-(2,4-dimethylphenyl)acetamide
Q27193585
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
indolesAny compound containing an indole skeleton.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (11)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASEHomo sapiens (human)Potency1.58490.003245.467312,589.2998AID2517
ATAD5 protein, partialHomo sapiens (human)Potency1.83560.004110.890331.5287AID504467
TDP1 proteinHomo sapiens (human)Potency5.48920.000811.382244.6684AID686978; AID686979
67.9K proteinVaccinia virusPotency1.41250.00018.4406100.0000AID720580
nuclear factor erythroid 2-related factor 2 isoform 2Homo sapiens (human)Potency23.10930.00419.984825.9290AID504444
huntingtin isoform 2Homo sapiens (human)Potency7.07950.000618.41981,122.0200AID1688
DNA polymerase betaHomo sapiens (human)Potency79.43280.022421.010289.1251AID485314
ras-related protein Rab-9AHomo sapiens (human)Potency3.16230.00022.621531.4954AID485297
nuclear receptor ROR-gamma isoform 1Mus musculus (house mouse)Potency18.16950.00798.23321,122.0200AID2546; AID2551
survival motor neuron protein isoform dHomo sapiens (human)Potency6.30960.125912.234435.4813AID1458
lamin isoform A-delta10Homo sapiens (human)Potency3.16230.891312.067628.1838AID1487
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (13)

Assay IDTitleYearJournalArticle
AID1745845Primary qHTS for Inhibitors of ATXN expression
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID504810Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID504812Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID651635Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (20.00)29.6817
2010's3 (60.00)24.3611
2020's1 (20.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.56

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.56 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.36 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.56)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]