2-(2-chlorophenyl)-5-(methylamino)-4-oxazolecarbonitrile

2-(2-chlorophenyl)-5-(methylamino)-4-oxazolecarbonitrile is a chemical compound with the molecular formula C11H8ClN3O. It's not commonly known by this name, but it's often referred to as **compound 1** or **the oxazole derivative** in scientific literature.

**Why is it important for research?**

This compound exhibits interesting biological activity, specifically as a **potent and selective inhibitor of the enzyme HDAC6** (histone deacetylase 6).

**What is HDAC6?**

HDAC6 is an enzyme involved in regulating cellular processes by removing acetyl groups from proteins. It plays a role in:

* **Protein degradation:** HDAC6 helps in the degradation of misfolded or damaged proteins, protecting cells from stress.
* **Microtubule stability:** It affects the stability of microtubules, which are important for cell division and transport.
* **Inflammation:** HDAC6 is involved in the regulation of inflammatory responses.

**Why is inhibiting HDAC6 important?**

Inhibiting HDAC6 has shown promise in treating a variety of diseases, including:

* **Cancer:** HDAC6 inhibitors can promote cell death in cancer cells and enhance the effectiveness of chemotherapy.
* **Neurodegenerative diseases:** By promoting protein degradation and protecting neurons, HDAC6 inhibitors may be helpful in treating diseases like Alzheimer's and Parkinson's.
* **Inflammatory diseases:** HDAC6 inhibitors can reduce inflammation by modulating immune responses.

**The significance of 2-(2-chlorophenyl)-5-(methylamino)-4-oxazolecarbonitrile:**

This specific compound demonstrates **high potency** in inhibiting HDAC6, making it a valuable tool for research. It's being investigated as a potential therapeutic agent for various diseases.

**Current research:**

Researchers are exploring the potential of 2-(2-chlorophenyl)-5-(methylamino)-4-oxazolecarbonitrile as a **lead compound** for developing new and improved HDAC6 inhibitors with even greater efficacy and safety profiles.

**Note:** While promising, it's important to remember that this compound is still under investigation and its potential therapeutic benefits are yet to be fully established.