Compounds > 2-(2-chlorobenzoyl)-4-chloro-n-methyl-n'-glycylglycinanilide
Page last updated: 2024-12-06

2-(2-chlorobenzoyl)-4-chloro-n-methyl-n'-glycylglycinanilide

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

2-(2-chlorobenzoyl)-4-chloro-N-methyl-N'-glycylglycinanilide is a complex organic molecule with a lengthy and somewhat confusing chemical name. It's not a commonly known or widely researched compound, and finding information about its specific importance in research is difficult.

Here's why:

* **Complex Structure:** The name itself hints at a complex structure with multiple functional groups. This makes it less likely to be a simple, well-studied molecule.
* **Limited Information:** A quick search on scientific databases (like PubChem or SciFinder) doesn't yield any significant results for this specific compound. It suggests that it might not be extensively studied or researched.

**Possible Reasons for Its Potential Importance:**

* **Novel Drug Candidate:** Given the complexity, it could be a potential lead compound for a novel drug. However, without further information, it's impossible to speculate on its potential therapeutic effects.
* **Intermediate in Synthesis:** It could be an intermediate compound used in the synthesis of other more important or well-known molecules.
* **Research Tool:** It might have specific properties that make it useful for studying certain biological processes or chemical reactions.

**To understand the true importance of this compound, you would need additional context:**

* **Research Area:** What field of research is this compound related to (e.g., medicinal chemistry, organic synthesis, materials science)?
* **Specific Study:** Is there a specific research paper or project that investigates this compound?
* **Properties:** What are the chemical and biological properties of this compound?

**Recommendation:**

To learn more about the significance of this compound, try to find the original source where it was mentioned or described. The context provided in that source should give you a better understanding of its relevance.

2-(2-chlorobenzoyl)-4-chloro-N-methyl-N'-glycylglycinanilide: used in the detection & analysis of pharmacologically active benzodiazepines; RN given refers to parent cpd; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID54760
CHEMBL ID36565
SCHEMBL ID637186
MeSH IDM0087523

Synonyms (23)

Synonym
lorzafona [spanish]
lorzafone
lorzafone anhydrous
glycyl-n-(4-chloro-2-(2-chlorobenzoyl)phenyl)-n-methylglycinamide
45-oo88s
glycinamide, glycyl-n-(4-chloro-2-(2-chlorobenzoyl)phenyl)-n-methyl-
2-(2-chlorobenzoyl)-4-chloro-n-methyl-n'-glycylglycinanilide
lorzafonum [latin]
n-(4-chloro-2-(2-chlorobenzoyl)phenyl)-glycyl-n-methylglycinamide
45-0088s
CHEMBL36565
2-amino-n-[2-[4-chloro-2-(2-chlorobenzoyl)-n-methylanilino]-2-oxoethyl]acetamide
lorzafona
lorzafone [inn]
59179-95-2
bi9ki838vi ,
unii-bi9ki838vi
lorzafonum
SCHEMBL637186
2-(2-aminoacetamido)-4'-chloro-2'-(o-chlorobenzoyl)-n-methylacetanilide
DTXSID30207909
Q27274680
AKOS040752681
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (19)

Assay IDTitleYearJournalArticle
AID131572Sedative activity was determined by measuring the loss of the righting reflux induced by chlorprothixene in mice1982Journal of medicinal chemistry, Dec, Volume: 25, Issue:12
Amino acid amide derivatives of 2-[3-(aminomethyl)-4H-1,2,4-triazol-4-yl]benzophenones, a novel class of annelated peptidoaminobenzophenones.
AID134240Acute toxicity expressed as LD50 in mice after oral administration.1981Journal of medicinal chemistry, Jan, Volume: 24, Issue:1
Novel peptidoaminobenzophenones, terminal N-substituted peptidoaminobenzophenones, and N-(acylglycyl)aminobenzophenones as open-ring derivatives of benzodiazepines.
AID128035Antagonism of pentylenetetrazole-induced convulsion in mice by oral administration.1981Journal of medicinal chemistry, Jan, Volume: 24, Issue:1
Novel peptidoaminobenzophenones, terminal N-substituted peptidoaminobenzophenones, and N-(acylglycyl)aminobenzophenones as open-ring derivatives of benzodiazepines.
AID131235Muscle relaxation activity using the rotarod performance test in mice by oral administration.1981Journal of medicinal chemistry, Jan, Volume: 24, Issue:1
Novel peptidoaminobenzophenones, terminal N-substituted peptidoaminobenzophenones, and N-(acylglycyl)aminobenzophenones as open-ring derivatives of benzodiazepines.
AID113320Dose required to prevent convulsion and death in 50% of mice during a 2 hr observation was obtained by graphical interpolation anti-pentylenetetrazole1980Journal of medicinal chemistry, Jul, Volume: 23, Issue:7
Peptidoaminobenzophenones, a novel class of ring-opened derivatives of 1,4-benzoidazepines.
AID117078Lethal dose (LD50) required to inhibit the spontaneous motor activity.1980Journal of medicinal chemistry, Jul, Volume: 23, Issue:7
Peptidoaminobenzophenones, a novel class of ring-opened derivatives of 1,4-benzoidazepines.
AID131236Muscle relaxation was determined by using rotatory drum (rotarod) in mice, activity is expressed as ED50 values1982Journal of medicinal chemistry, Dec, Volume: 25, Issue:12
Amino acid amide derivatives of 2-[3-(aminomethyl)-4H-1,2,4-triazol-4-yl]benzophenones, a novel class of annelated peptidoaminobenzophenones.
AID115611Minimum effective dose (MED) required for the potentiation of thiopental sodium induced loss of the righting reflex1980Journal of medicinal chemistry, Jul, Volume: 23, Issue:7
Peptidoaminobenzophenones, a novel class of ring-opened derivatives of 1,4-benzoidazepines.
AID109527Antifighting activity was measured by the antagonism against foot-shock induced fighting1980Journal of medicinal chemistry, Jul, Volume: 23, Issue:7
Peptidoaminobenzophenones, a novel class of ring-opened derivatives of 1,4-benzoidazepines.
AID114833Effective dose required for 50% reduction of the control response was obtained by graphical interpolation rotarod performance1980Journal of medicinal chemistry, Jul, Volume: 23, Issue:7
Peptidoaminobenzophenones, a novel class of ring-opened derivatives of 1,4-benzoidazepines.
AID23561Solubility was calculated at 4 pH1980Journal of medicinal chemistry, Jul, Volume: 23, Issue:7
Peptidoaminobenzophenones, a novel class of ring-opened derivatives of 1,4-benzoidazepines.
AID128826Antianxiety activity was determined by measuring the antagonism of foot shock induced fighting (taming) in mice1982Journal of medicinal chemistry, Dec, Volume: 25, Issue:12
Amino acid amide derivatives of 2-[3-(aminomethyl)-4H-1,2,4-triazol-4-yl]benzophenones, a novel class of annelated peptidoaminobenzophenones.
AID131571Sedative activity was determined by measuring the inhibition of spontaneous motor activity1982Journal of medicinal chemistry, Dec, Volume: 25, Issue:12
Amino acid amide derivatives of 2-[3-(aminomethyl)-4H-1,2,4-triazol-4-yl]benzophenones, a novel class of annelated peptidoaminobenzophenones.
AID131573Sedative activity was determined by measuring the loss of the righting reflux induced by thiopental sodium in mice1982Journal of medicinal chemistry, Dec, Volume: 25, Issue:12
Amino acid amide derivatives of 2-[3-(aminomethyl)-4H-1,2,4-triazol-4-yl]benzophenones, a novel class of annelated peptidoaminobenzophenones.
AID129148Anticonvulsant activity was determined as the degree of protection against convulsions induced by pentylenetetrazole in mice1982Journal of medicinal chemistry, Dec, Volume: 25, Issue:12
Amino acid amide derivatives of 2-[3-(aminomethyl)-4H-1,2,4-triazol-4-yl]benzophenones, a novel class of annelated peptidoaminobenzophenones.
AID111353Spontaneous motor activity of mice was estimated after 60 minutes of oral administration.1980Journal of medicinal chemistry, Jul, Volume: 23, Issue:7
Peptidoaminobenzophenones, a novel class of ring-opened derivatives of 1,4-benzoidazepines.
AID23559Solubility was calculated 6 pH1980Journal of medicinal chemistry, Jul, Volume: 23, Issue:7
Peptidoaminobenzophenones, a novel class of ring-opened derivatives of 1,4-benzoidazepines.
AID23558Solubility was calculated 5 pH1980Journal of medicinal chemistry, Jul, Volume: 23, Issue:7
Peptidoaminobenzophenones, a novel class of ring-opened derivatives of 1,4-benzoidazepines.
AID23560Solubility was calculated at 2.0 pH1980Journal of medicinal chemistry, Jul, Volume: 23, Issue:7
Peptidoaminobenzophenones, a novel class of ring-opened derivatives of 1,4-benzoidazepines.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (11)

TimeframeStudies, This Drug (%)All Drugs %
pre-199011 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.88

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.88 (24.57)
Research Supply Index2.56 (2.92)
Research Growth Index4.45 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.88)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other12 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
glycine
[no description available]		3.4680alpha-amino acid;
amino acid zwitterion;
proteinogenic amino acid;
serine family amino acid		EC 2.1.2.1 (glycine hydroxymethyltransferase) inhibitor;
fundamental metabolite;
hepatoprotective agent;
micronutrient;
neurotransmitter;
NMDA receptor agonist;
nutraceutical
alprazolam
Alprazolam: A triazolobenzodiazepine compound with antianxiety and sedative-hypnotic actions, that is efficacious in the treatment of PANIC DISORDERS, with or without AGORAPHOBIA, and in generalized ANXIETY DISORDERS. (From AMA Drug Evaluations Annual, 1994, p238). alprazolam : A member of the class of triazolobenzodiazepines that is 4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine carrying methyl, phenyl and chloro substituents at positions 1, 6 and 8 respectively. Alprazolam is only found in individuals that have taken this drug.		1.9610organochlorine compound;
triazolobenzodiazepine		anticonvulsant;
anxiolytic drug;
GABA agonist;
muscle relaxant;
sedative;
xenobiotic
chlordiazepoxide
Chlordiazepoxide: An anxiolytic benzodiazepine derivative with anticonvulsant, sedative, and amnesic properties. It has also been used in the symptomatic treatment of alcohol withdrawal.. chlordiazepoxide : A benzodiazepine that is 3H-1,4-benzodiazepine 4-oxide substituted by a chloro group at position 7, a phenyl group at position 5 and a methylamino group at position 2.		2.3620benzodiazepine
nordazepam
Nordazepam: An intermediate in the metabolism of DIAZEPAM to OXAZEPAM. It may have actions similar to those of diazepam.. nordazepam : A 1,4-benzodiazepinone having phenyl and chloro substituents at positions 5 and 7 respectively; it has anticonvulsant, anxiolytic, muscle relaxant and sedative properties but is used primarily in the treatment of anxiety.		1.96101,4-benzodiazepinone;
organochlorine compound		anticonvulsant;
anxiolytic drug;
GABA modulator;
human metabolite;
sedative
diazepam
Diazepam: A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.. diazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a methyl group at position 1 and a phenyl group at position 5.		2.87401,4-benzodiazepinone;
organochlorine compound		anticonvulsant;
anxiolytic drug;
environmental contaminant;
sedative;
xenobiotic
estazolam
Estazolam: A benzodiazepine with anticonvulsant, hypnotic, and muscle relaxant properties. It has been shown in some cases to be more potent than DIAZEPAM or NITRAZEPAM.. estazolam : A triazolo[4,3-a][1,4]benzodiazepine having a phenyl group at position 6 and a chloro substituent at position 8. A short-acting benzodiazepine with general properties similar to diazepam, it is given by mouth as a hypnotic in the short-term management of insomnia.		1.9610triazoles;
triazolobenzodiazepine		anticonvulsant;
anxiolytic drug;
GABA modulator
lorazepam
Lorazepam: A benzodiazepine used as an anti-anxiety agent with few side effects. It also has hypnotic, anticonvulsant, and considerable sedative properties and has been proposed as a preanesthetic agent.		2.3620benzodiazepine
nitrazepam
Nitrazepam: A benzodiazepine derivative used as an anticonvulsant and hypnotic.. nitrazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one which is substituted at positions 5 and 7 by phenyl and nitro groups, respectively. It is used as a hypnotic for the short-term management of insomnia and for the treatment of epileptic spasms in infants (West's syndrome).		1.96101,4-benzodiazepinone;
C-nitro compound		anticonvulsant;
antispasmodic drug;
drug metabolite;
GABA modulator;
sedative
triazolam
Triazolam: A short-acting benzodiazepine used in the treatment of insomnia. Some countries temporarily withdrew triazolam from the market because of concerns about adverse reactions, mostly psychological, associated with higher dose ranges. Its use at lower doses with appropriate care and labeling has been reaffirmed by the FDA and most other countries.		1.9610triazolobenzodiazepinesedative
3,5-dibromosalicylaldehyde
3,5-dibromosalicylaldehyde: structure in Merck Index, 9th ed, #2995		1.9610
2-chlorodiazepam
[no description available]		1.9610
aminoquinolone
aminoquinolone: metabolite of peptido-aminobenzophenone; structure given in first source		1.9510
ConditionIndicatedRelationship StrengthStudiesTrials
Anesthesia
A state characterized by loss of feeling or sensation. This depression of nerve function is usually the result of pharmacologic action and is induced to allow performance of surgery or other painful procedures.		01.9610
Aggression
Behavior which may be manifested by destructive and attacking action which is verbal or physical, by covert attitudes of hostility or by obstructionism.		02.3620