Page last updated: 2024-12-06

2-(2',4'-diaminophenoxy)ethanol

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

2-(2',4'-diaminophenoxy)ethanol, also known as **2-(2,4-diaminophenoxy)ethanol** or **DAPOE**, is a chemical compound that plays a crucial role in research due to its unique properties and applications.

**Properties:**

* **Structure:** DAPOE is a colorless to pale yellow liquid with a molecular formula of C8H12N2O2. It is composed of a phenol ring with two amino groups (NH2) at the 2' and 4' positions, and an ethoxy group (-OCH2CH2OH) attached to the phenol ring.
* **Reactivity:** DAPOE is a highly reactive compound due to the presence of the amino groups, which can participate in various chemical reactions, including condensation, alkylation, and acylation.
* **Solubility:** It is soluble in water and organic solvents, which makes it suitable for various experimental applications.
* **Biological activity:** DAPOE has been found to exhibit biological activity, including antibacterial, antifungal, and antioxidant properties.

**Research Importance:**

DAPOE is important for research in various fields, including:

* **Materials science:** It is used as a precursor in the synthesis of polymers, resins, and other materials with specific properties.
* **Biochemistry:** DAPOE is used as a reagent in enzymatic assays and protein modification studies.
* **Pharmacology:** Its biological activity makes it a promising candidate for developing new drugs, particularly in the areas of antibacterial and antifungal therapies.
* **Environmental science:** DAPOE is studied for its potential use in bioremediation, where it can help remove pollutants from the environment.
* **Organic synthesis:** DAPOE is a versatile building block for the synthesis of complex organic molecules.

**Specific Research Examples:**

* **Polymer synthesis:** DAPOE is used to synthesize polyamides and polyurethanes with improved properties, such as thermal stability and mechanical strength.
* **Antibacterial activity:** Studies have shown that DAPOE exhibits significant antibacterial activity against a broad range of bacteria, including Staphylococcus aureus and Escherichia coli.
* **Antioxidant activity:** DAPOE has been found to scavenge free radicals and protect cells from oxidative damage, suggesting its potential as a therapeutic agent for diseases related to oxidative stress.

**Conclusion:**

2-(2',4'-diaminophenoxy)ethanol is a versatile chemical compound with unique properties that make it valuable in various research areas. Its reactivity, solubility, and biological activity make it a promising candidate for the development of new materials, drugs, and environmental solutions.

2-(2',4'-diaminophenoxy)ethanol: RN given refers to parent cpd [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID47933
SCHEMBL ID35916
MeSH IDM0101568

Synonyms (20)

Synonym
2-(2,4-diaminophenoxy)ethanol
FT-0655693
AKOS006274686
ethanol, 2-(2,4-diaminophenoxy)-
unii-8di56tbp4b
2-(2',4'-diaminophenoxy)ethanol
8di56tbp4b ,
2,4-diamino-1-(2-hydroxyethoxy)benzene
2,4-diaminophenyl .beta.-hydroxyethyl ether
3-amino-4-(2'-hydroxyethyloxy)aniline
SCHEMBL35916
2-(2',4'-diamino-phenoxy)ethanol
WCPGNFONICRLCL-UHFFFAOYSA-N
DTXSID0073619
2-(2,4-diaminophenoxy)ethan-1-ol
F20765
2,4-diamino phenoxy ethanol hydrochloride
mfcd00190137
Q27270229
PD159030

Research Excerpts

Dosage Studied

ExcerptRelevanceReference
" No increase in the incidence of micronucleated polychromatic erythrocytes was observed for any group dosed with 2-(2',4'-diaminophenoxy)ethanol, although evidence of bone-marrow toxicity was observed at all 3 dosages."( An evaluation of the mutagenic potential of 2-(2',4'-diaminophenoxy)ethanol using the micronucleus test.
Richardson, JC; Richold, M, 1982
)
0.74
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (14)

TimeframeStudies, This Drug (%)All Drugs %
pre-199013 (92.86)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's1 (7.14)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.61

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.61 (24.57)
Research Supply Index2.71 (2.92)
Research Growth Index4.32 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.61)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies1 (7.14%)4.05%
Observational0 (0.00%)0.25%
Other13 (92.86%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]