Page last updated: 2024-12-07

2-(2-(3-iodo-4-hydroxyphenyl)-6-benzimidazolyl)-6-(1-methyl-4-piperazyl)benzimidazole

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

The compound you're describing, 2-(2-(3-iodo-4-hydroxyphenyl)-6-benzimidazolyl)-6-(1-methyl-4-piperazyl)benzimidazole, is a complex organic molecule with several interesting features:

**Structure:**

* It contains two benzimidazole rings connected by a phenyl ring.
* One benzimidazole ring is substituted with a 1-methyl-4-piperazyl group.
* The other benzimidazole ring is substituted with a 3-iodo-4-hydroxyphenyl group.

**Potential Biological Activity:**

This molecule is a **synthetic derivative of a natural product** called **benzimidazole alkaloids**. Benzimidazole alkaloids are known to possess a wide range of biological activities, including:

* **Anti-cancer properties:** Some benzimidazoles have shown promise in treating various cancers due to their ability to inhibit cell growth and induce apoptosis (programmed cell death).
* **Anti-inflammatory activity:** Certain benzimidazoles can reduce inflammation by targeting inflammatory pathways.
* **Antimicrobial effects:** They can act against bacteria, fungi, and parasites.
* **Immunostimulatory effects:** Some benzimidazoles can enhance the immune response.

**Importance for Research:**

The specific compound you mentioned (2-(2-(3-iodo-4-hydroxyphenyl)-6-benzimidazolyl)-6-(1-methyl-4-piperazyl)benzimidazole) has not been extensively studied yet. However, its complex structure and potential biological activity make it an intriguing molecule for research. Researchers are interested in:

* **Understanding its mechanism of action:** How does this compound interact with biological targets to exert its effects?
* **Exploring its potential therapeutic applications:** Could this molecule be used to develop new drugs for various diseases?
* **Optimizing its properties:** Can researchers modify the structure of this compound to enhance its potency, selectivity, or bioavailability?

**Further Research:**

Before any potential therapeutic applications can be considered, further research is necessary to investigate the compound's safety, efficacy, and pharmacokinetic properties. This includes:

* **In vitro studies:** Evaluating the compound's activity in cell cultures.
* **In vivo studies:** Testing the compound in animal models.
* **Clinical trials:** Conducting human trials to assess the compound's safety and effectiveness.

Overall, 2-(2-(3-iodo-4-hydroxyphenyl)-6-benzimidazolyl)-6-(1-methyl-4-piperazyl)benzimidazole is a promising candidate for drug development research due to its potential biological activity and structural complexity. However, significant research is still required to fully understand its properties and explore its therapeutic potential.

2-(2-(3-iodo-4-hydroxyphenyl)-6-benzimidazolyl)-6-(1-methyl-4-piperazyl)benzimidazole: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID129169
SCHEMBL ID10070224
MeSH IDM0176731

Synonyms (12)

Synonym
iodohoechst 33258
HY-15630
CS-1318
106050-84-4
2-(2-(3-iodo-4-hydroxyphenyl)-6-benzimidazolyl)-6-(1-methyl-4-piperazyl)benzimidazole
phenol, 2-iodo-4-(5-(4-methyl-1-piperazinyl)(2,5'-bi-1h-benzimidazol)-2'-yl)-
SCHEMBL10070224
A906052
(e)-2-iodo-4-(6-(4-methylpiperazin-1-yl)-1',3'-dihydro-1h,2'h-[2,5'-bibenzo[d]imidazol]-2'-ylidene)cyclohexa-2,5-dien-1-one
2-iodo-4-[6-[6-(4-methylpiperazin-1-yl)-1h-benzimidazol-2-yl]-1h-benzimidazol-2-yl]phenol
AKOS040744080
PD118611
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (4)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's2 (50.00)18.2507
2000's2 (50.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.56

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.56 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.36 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.56)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]