Compounds > 2-(1-hydroxyethyl)thiamine pyrophosphate
Page last updated: 2024-12-08

2-(1-hydroxyethyl)thiamine pyrophosphate

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

2-(1-hydroxyethyl)thiamine pyrophosphate, also known as **hydroxyethyl thiamine pyrophosphate** (HETPP), is a key intermediate in the **pyruvate dehydrogenase complex (PDC) reaction**, which plays a vital role in cellular metabolism.

**Here's why HETPP is important for research:**

* **Understanding Enzyme Mechanism:** HETPP represents a crucial step in the PDC reaction, where it is formed from the decarboxylation of pyruvate. Studying HETPP helps scientists understand the detailed mechanism of PDC, a complex multi-enzyme system that links glycolysis to the citric acid cycle.

* **Drug Development:** The PDC is a prime target for drug development. Understanding the role of HETPP in the PDC reaction can lead to the development of drugs that can:
* **Modulate PDC activity:** By interfering with the formation or utilization of HETPP, researchers can potentially develop drugs that regulate the activity of the PDC, impacting cellular metabolism and disease conditions.
* **Treat diseases:** PDC dysfunction is implicated in various diseases, such as diabetes, cancer, and neurological disorders. By targeting the formation or breakdown of HETPP, researchers aim to develop drugs that can treat or alleviate these conditions.

* **Biomarker Discovery:** The levels of HETPP in cells can reflect the activity of the PDC and may serve as potential biomarkers for various disease states. Research on HETPP could lead to the development of diagnostic tools for early disease detection and monitoring.

* **Metabolic Engineering:** Manipulating the levels of HETPP in cells can be used for metabolic engineering applications, such as optimizing biofuel production or creating cells with enhanced production of desired metabolites.

**In summary,** HETPP is a crucial intermediate in the PDC reaction and holds significant research value in understanding enzyme mechanisms, drug development, biomarker discovery, and metabolic engineering.

2-(1-hydroxyethyl)thiamine pyrophosphate: RN given refers to Cl [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID152298
SCHEMBL ID1060022
MeSH IDM0137066

Synonyms (7)

Synonym
hydroxyethylthiamin pyrophosphate
(alpha-hydroxyethyl)thiamin diphosphate
2-(1-hydroxyethyl)thiamine pyrophosphate
ohet-tpp
20319-27-1
thiazolium, 3-((4-amino-2-methyl-5-pyrimidinyl)methyl)-2-(1-hydroxyethyl)-4-methyl-5-(4,6,6-trihydroxy-3,5-dioxa-4,6-diphosphahex-1-yl)-, chloride, p,p'-dioxide
SCHEMBL1060022
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (10)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (10.00)18.7374
1990's3 (30.00)18.2507
2000's5 (50.00)29.6817
2010's1 (10.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.45

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.45 (24.57)
Research Supply Index2.40 (2.92)
Research Growth Index4.85 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.45)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other10 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
pyruvic acid
Pyruvic Acid: An intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed). pyruvic acid : A 2-oxo monocarboxylic acid that is the 2-keto derivative of propionic acid. It is a metabolite obtained during glycolysis.		2.93402-oxo monocarboxylic acidcofactor;
fundamental metabolite
thiamine
thiamine(1+) : A primary alcohol that is 1,3-thiazol-3-ium substituted by (4-amino-2-methylpyrimidin-5-yl)methyl, methyl and 2-hydroxyethyl groups at positions 3, 4 and 5, respectively.		210primary alcohol;
vitamin B1		Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
tryptophan
Tryptophan: An essential amino acid that is necessary for normal growth in infants and for NITROGEN balance in adults. It is a precursor of INDOLE ALKALOIDS in plants. It is a precursor of SEROTONIN (hence its use as an antidepressant and sleep aid). It can be a precursor to NIACIN, albeit inefficiently, in mammals.. tryptophan : An alpha-amino acid that is alanine bearing an indol-3-yl substituent at position 3.		1.9610erythrose 4-phosphate/phosphoenolpyruvate family amino acid;
L-alpha-amino acid zwitterion;
L-alpha-amino acid;
proteinogenic amino acid;
tryptophan zwitterion;
tryptophan		antidepressant;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite
thiamine pyrophosphate
Thiamine Pyrophosphate: The coenzyme form of Vitamin B1 present in many animal tissues. It is a required intermediate in the PYRUVATE DEHYDROGENASE COMPLEX and the KETOGLUTARATE DEHYDROGENASE COMPLEX.. thiamine(1+) diphosphate chloride : An organic chloride salt of thiamine(1+) diphosphate.		3.7100organic chloride salt;
vitamin B1
paraquat
Paraquat: A poisonous dipyridilium compound used as contact herbicide. Contact with concentrated solutions causes irritation of the skin, cracking and shedding of the nails, and delayed healing of cuts and wounds.. paraquat : An organic cation that consists of 4,4'-bipyridine bearing two N-methyl substituents loctated at the 1- and 1'-positions.		1.9910organic cationgeroprotector;
herbicide
cadmium
Cadmium: An element with atomic symbol Cd, atomic number 48, and atomic weight 112.41. It is a metal and ingestion will lead to CADMIUM POISONING.. elemental cadmium : An element in the zinc group of the periodic table with atomic number 48, atomic mass 112, M.P. 321degreeC, and B.P. 765degreeC). An odourless, tasteless, and highly poisonous soft, ductile, lustrous metal with electropositive properties. It has eight stable isotopes: (106)Cd, (108)Cd,(110)Cd, (111)Cd, (112)Cd, (113)Cd, (114)Cd and (116)Cd, with (112)Cd and (114)Cd being the most common.		210cadmium molecular entity;
zinc group element atom
alpha-acetolactate
alpha-acetolactate: RN given refers to cpd without isomeric designation		2.0510
coenzyme a
[no description available]		1.9910adenosine 3',5'-bisphosphatecoenzyme;
Escherichia coli metabolite;
mouse metabolite
hexacyanoferrate iii
hexacyanoferrate III: RN given refers to parent cpd		1.9710
flavin-adenine dinucleotide
Flavin-Adenine Dinucleotide: A condensation product of riboflavin and adenosine diphosphate. The coenzyme of various aerobic dehydrogenases, e.g., D-amino acid oxidase and L-amino acid oxidase. (Lehninger, Principles of Biochemistry, 1982, p972)		2.4220flavin adenine dinucleotide;
vitamin B2		cofactor;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
prosthetic group
ConditionIndicatedRelationship StrengthStudiesTrials