The compound you described, **2-(1,3-dioxo-2-isoindolyl)-N-(4-methyl-1,3-benzothiazol-2-yl)acetamide**, is a complex organic molecule that has shown potential in several research areas. It is essentially a derivative of phthalimide, a common building block in organic synthesis, attached to a substituted benzothiazole through an acetamide linker.
Here's why it's important for research:
**1. Potential Anti-Cancer Activity:** Studies have suggested that this compound possesses anti-cancer activity. Its mechanism of action might involve inhibiting the growth of cancer cells, potentially by targeting specific cellular pathways.
**2. Potential Anti-Inflammatory Activity:** Some research indicates that this compound may also have anti-inflammatory properties. This could be attributed to its ability to modulate inflammatory signaling pathways in cells.
**3. Potential Antimicrobial Activity:** Preliminary research suggests that the compound may also exhibit antimicrobial activity. Its effectiveness against specific bacteria or fungi could be a valuable area for further investigation.
**4. Potential for Drug Development:** Due to its diverse biological activity, this compound could be a promising lead molecule for the development of new drugs to treat various diseases. However, further research is needed to confirm its safety and efficacy in humans.
**5. Synthetic Importance:** The compound itself is not a readily available drug. However, its synthesis involves the use of interesting and potentially applicable reaction chemistry, which could be further utilized in the development of new synthetic strategies.
**Important Note:** The research on this compound is still in its early stages, and much remains to be discovered. Further studies are required to fully understand its biological effects, toxicity, and potential applications.
It's crucial to remember that scientific research is a continuous process of exploration and verification. Findings from early studies are not necessarily conclusive, and further investigations are needed to translate potential benefits into tangible therapeutic solutions.
ID Source | ID |
---|---|
PubMed CID | 1241849 |
CHEMBL ID | 1539000 |
CHEBI ID | 119849 |
Synonym |
---|
HMS2572G11 |
OPREA1_720827 |
smr000200519 |
2-(1,3-dioxo-1,3-dihydro-2h-isoindol-2-yl)-n-(4-methyl-1,3-benzothiazol-2-yl)acetamide |
MLS000581911 , |
STK176203 |
CHEBI:119849 |
AKOS003011810 |
2-(1,3-dioxoisoindol-2-yl)-n-(4-methyl-1,3-benzothiazol-2-yl)acetamide |
CHEMBL1539000 |
2-(1,3-dioxo-2,3-dihydro-1h-isoindol-2-yl)-n-(4-methyl-1,3-benzothiazol-2-yl)acetamide |
2-(1,3-dioxo-2-isoindolyl)-n-(4-methyl-1,3-benzothiazol-2-yl)acetamide |
Q27207330 |
SR-01000284139-1 |
sr-01000284139 |
Class | Description |
---|---|
phthalimides | A dicarboximide that is phthalimide or derivatives obtained from it by the formal replacement of one or more hydrogens. |
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] |
Protein | Taxonomy | Measurement | Average (µ) | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
---|---|---|---|---|---|---|---|
Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 56.2341 | 0.0447 | 17.8581 | 100.0000 | AID485294 |
Chain A, Cruzipain | Trypanosoma cruzi | Potency | 39.8107 | 0.0020 | 14.6779 | 39.8107 | AID1476 |
apical membrane antigen 1, AMA1 | Plasmodium falciparum 3D7 | Potency | 1.1220 | 0.7079 | 12.1943 | 39.8107 | AID720542 |
euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 0.1122 | 0.0355 | 20.9770 | 89.1251 | AID504332 |
huntingtin isoform 2 | Homo sapiens (human) | Potency | 35.4813 | 0.0006 | 18.4198 | 1,122.0200 | AID1688 |
nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 25.1189 | 0.0079 | 8.2332 | 1,122.0200 | AID2546 |
geminin | Homo sapiens (human) | Potency | 5.1735 | 0.0046 | 11.3741 | 33.4983 | AID624297 |
histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 5.6234 | 0.2512 | 15.8432 | 39.8107 | AID504327 |
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] |
Assay ID | Title | Year | Journal | Article |
---|---|---|---|---|
AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
AID651635 | Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression | |||
AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
AID504812 | Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7 | A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
AID1745845 | Primary qHTS for Inhibitors of ATXN expression | |||
AID504810 | Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7 | A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Timeframe | Studies, This Drug (%) | All Drugs % |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 1 (20.00) | 29.6817 |
2010's | 3 (60.00) | 24.3611 |
2020's | 1 (20.00) | 2.80 |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.56) All Compounds (24.57) |
Publication Type | This drug (%) | All Drugs (%) |
---|---|---|
Trials | 0 (0.00%) | 5.53% |
Reviews | 0 (0.00%) | 6.00% |
Case Studies | 0 (0.00%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 5 (100.00%) | 84.16% |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |