## 2-((Phenylamino)methyl)isoindoline-1,3-dione: A Chemical Puzzle Piece for Research
**2-((Phenylamino)methyl)isoindoline-1,3-dione** is a complex organic compound that belongs to the **phthalimide** family. It's essentially a phthalimide with a phenylamino group attached to its methylene bridge. This specific structure makes it a valuable tool in various research areas.
**Here's a breakdown of its importance:**
* **Synthetic Versatility:** The compound acts as a key intermediate in organic synthesis. It can be easily modified through various chemical reactions, allowing researchers to build a vast array of new molecules with desired properties.
* **Potential Medicinal Applications:** 2-((Phenylamino)methyl)isoindoline-1,3-dione and its derivatives exhibit a range of biological activities, including antibacterial, antifungal, and antitumor properties. This makes them promising candidates for drug development.
* **Material Science Applications:** The compound and its analogues have potential for use in materials science, particularly in the development of advanced polymers, electronic devices, and optical materials.
* **Fundamental Chemistry Research:** The complex structure of the compound allows researchers to study various chemical concepts, such as **reaction mechanisms, stereochemistry, and molecular interactions**, contributing to the advancement of our understanding of organic chemistry.
**However, it's crucial to remember that research is ongoing, and the true potential of 2-((phenylamino)methyl)isoindoline-1,3-dione is still being explored.**
**Here are some additional details to consider:**
* The compound's synthesis often involves a **multi-step process**, requiring specific reagents and conditions.
* Its **biological activity** can vary significantly depending on the specific structure and modifications made to the molecule.
* Research on this compound is still relatively new, and more **investigation** is needed to understand its full potential and limitations.
Overall, 2-((phenylamino)methyl)isoindoline-1,3-dione serves as a versatile building block in various research fields, holding promise for exciting advancements in the future.
2-((phenylamino)methyl)isoindoline-1,3-dione: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 241616 |
| CHEMBL ID | 38326 |
| SCHEMBL ID | 9304609 |
| MeSH ID | M000609559 |
| Synonym |
|---|
| nsc49226 |
| 13314-96-0 |
| nsc-49226 |
| TIMTEC1_000200 |
| 2-phenylaminomethyl-isoindole-1,3-dione |
| smr000001082 |
| MLS000031434 |
| NCGC00032590-03 |
| STK246941 |
| 2-[(phenylamino)methyl]-1h-isoindole-1,3(2h)-dione |
| HMS1534J02 |
| CHEMBL38326 |
| 2-(anilinomethyl)-1h-isoindole-1,3(2h)-dione |
| AKOS000668787 |
| 2-(anilinomethyl)isoindole-1,3-dione |
| 2-[(phenylamino)methyl]-2,3-dihydro-1h-isoindole-1,3-dione |
| HMS2362L09 |
| SCHEMBL9304609 |
| sr-01000513192 |
| SR-01000513192-1 |
| mfcd00221821 |
| 1h-isoindole-1,3(2h)-dione, 2-[(phenylamino)methyl]- |
| DTXSID70287149 |
| 2-[(phenylamino)methyl]-isoindole-1,3-dione |
| 2-((phenylamino)methyl)isoindoline-1,3-dione |
| SB64821 |
| LS-05806 |
| CS-0315190 |
| Protein | Taxonomy | Measurement | Average (µ) | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 0.5623 | 0.0447 | 17.8581 | 100.0000 | AID485294 |
| TDP1 protein | Homo sapiens (human) | Potency | 29.0929 | 0.0008 | 11.3822 | 44.6684 | AID686979 |
| nonstructural protein 1 | Influenza A virus (A/WSN/1933(H1N1)) | Potency | 10.0000 | 0.2818 | 9.7212 | 35.4813 | AID2326 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 100.0000 | 0.3548 | 28.0659 | 89.1251 | AID504847 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID651635 | Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression | |||
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID504810 | Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7 | A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID1745845 | Primary qHTS for Inhibitors of ATXN expression | |||
| AID504812 | Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7 | A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID588519 | A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities | 2011 | Antiviral research, Sep, Volume: 91, Issue:3 | High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors. |
| AID540299 | A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis | 2010 | Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21 | Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 6 (75.00) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.15) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 8 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||