17-phenylprostaglandin f2alpha profile

## 17-Phenylprostaglandin F2α (17-PhPGF2α)

17-Phenylprostaglandin F2α (17-PhPGF2α) is a synthetic analog of prostaglandin F2α (PGF2α), a naturally occurring hormone involved in various physiological processes. The key difference between 17-PhPGF2α and PGF2α is the presence of a phenyl ring at the 17-position of the prostaglandin molecule.

**Why is 17-PhPGF2α important for research?**

17-PhPGF2α is a valuable tool in research due to its **increased stability and potency** compared to natural PGF2α. This makes it a more efficient and reliable compound for studying the biological effects of PGF2α. Here are some key reasons why:

* **Longer half-life:** 17-PhPGF2α has a longer half-life than PGF2α, meaning it remains active in the body for a longer time. This allows researchers to study its effects over extended periods.
* **Increased potency:** 17-PhPGF2α is more potent than PGF2α, requiring lower doses to achieve similar biological effects. This can be beneficial for studying sensitive tissues and minimizing potential side effects.
* **Selective agonist:** 17-PhPGF2α acts as a selective agonist for specific prostaglandin receptors, such as the FP receptor. This allows researchers to target specific pathways and study their roles in different biological processes.

**Applications in research:**

17-PhPGF2α is used in various research areas, including:

* **Reproductive biology:** Studies on ovulation, implantation, and pregnancy.
* **Ophthalmology:** Investigations on glaucoma and retinal function.
* **Gastrointestinal physiology:** Research on gastric motility and mucosal protection.
* **Cardiovascular research:** Studies on blood pressure, heart rate, and vasoconstriction.
* **Neuroscience:** Investigations on the role of prostaglandins in neuronal function and pain perception.

**Future potential:**

The unique properties of 17-PhPGF2α make it a promising candidate for the development of novel therapeutic agents. Research continues to explore its potential in treating conditions like:

* **Uterine fibroids:** By inducing uterine contractions, it could be used to shrink or remove fibroids.
* **Premature labor:** As an abortifacient, it could potentially prevent preterm delivery.
* **Glaucoma:** By reducing intraocular pressure, it could help manage glaucoma.

**Conclusion:**

17-PhPGF2α is a valuable research tool due to its enhanced stability, potency, and selective agonist properties. It is extensively used in diverse research areas and holds promise for the development of new therapeutic strategies in various medical fields.

17-phenylprostaglandin F2alpha: used in treatment of vasomotor rhinitis [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	6441695
MeSH ID	M0088218

Synonym
17-phenylprostaglandin f2alpha
(z)-7-[(1r,2r,3r,5s)-3,5-dihydroxy-2-[(e,3s)-3-hydroxy-5-phenyloct-1-enyl]cyclopentyl]hept-5-enoic acid
prosta-5,13-dien-1-oic acid, 11,15-dihydroxy-9-oxo-17-phenyl-, (5z,11alpha,13e,15s)-
17-phenyl-pgf2alpha
55582-75-7

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	2 (28.57)	18.7374
1990's	1 (14.29)	18.2507
2000's	4 (57.14)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	7 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
carbachol Carbachol: A slowly hydrolyzed CHOLINERGIC AGONIST that acts at both MUSCARINIC RECEPTORS and NICOTINIC RECEPTORS.	2.02	1	ammonium salt; carbamate ester	cardiotonic drug; miotic; muscarinic agonist; nicotinic acetylcholine receptor agonist; non-narcotic analgesic
prostaglandin d2 Prostaglandin D2: The principal cyclooxygenase metabolite of arachidonic acid. It is released upon activation of mast cells and is also synthesized by alveolar macrophages. Among its many biological actions, the most important are its bronchoconstrictor, platelet-activating-factor-inhibitory, and cytotoxic effects.. prostaglandin D2 : A member of the class of prostaglandins D that is prosta-5,13-dien-1-oic acid substituted by hydroxy groups at positions 9 and 15 and an oxo group at position 11 (the 5Z,9alpha,13E,15S- stereoisomer).	2	1	prostaglandins D	human metabolite; mouse metabolite
dinoprostone prostaglandin E2 : Prostaglandin F2alpha in which the hydroxy group at position 9 has been oxidised to the corresponding ketone. Prostaglandin E2 is the most common and most biologically potent of mammalian prostaglandins.	1.98	1	prostaglandins E	human metabolite; mouse metabolite; oxytocic
dinoprost Dinoprost: A naturally occurring prostaglandin that has oxytocic, luteolytic, and abortifacient activities. Due to its vasocontractile properties, the compound has a variety of other biological actions.. prostaglandin F2alpha : A prostaglandins Falpha that is prosta-5,13-dien-1-oic acid substituted by hydroxy groups at positions 9, 11 and 15. It is a naturally occurring prostaglandin used to induce labor.	3.37	7	monocarboxylic acid; prostaglandins Falpha	human metabolite; mouse metabolite
alprostadil [no description available]	1.96	1	prostaglandins E	anticoagulant; human metabolite; platelet aggregation inhibitor; vasodilator agent
prostaglandin f1 prostaglandin F1: was EN to PROSTAGLANDINS F (75-81); RN given refers to (9 alpha,11 alpha,13E,15S)-isomer	1.96	1	prostaglandins Falpha	human metabolite
bimatoprost Bimatoprost: A cloprostenol-derived amide that is used as an ANTIHYPERTENSIVE AGENT in the treatment of OPEN-ANGLE GLAUCOMA and OCULAR HYPERTENSION.	2.71	3	monocarboxylic acid amide	antiglaucoma drug; antihypertensive agent
cloprostenol Cloprostenol: A synthetic prostaglandin F2alpha analog. The compound has luteolytic effects and is used for the synchronization of estrus in cattle.	2.71	3	prostanoid
fluprostenol fluprostenol: synthetic prostaglandin F 2 alpha analog used as an abortifacient; RN given refers to ((1alpha(Z),2beta(1E,3R*),3alpha,5alpha)-(+-))-isomer. fluprostenol : An organofluorine compound that is racemic prostaglandin F2alpha in which the pentyl group is replaced by a 3-(trifluoromethyl)phenoxymethyl group. A synthetic analogue of prostaglandin F2alpha, ophthalmic solutions of its isopropyl ester prodrug, travoprost, are used as a topical medication for controlling the progression of open-angle glaucoma and ocular hypertension, by reducing intraocular pressure. The isopropyl ester group of travoprost is hydrolysed to the biologically active free acid by esterases in the cornea.	2	1	(trifluoromethyl)benzenes; hydroxy monocarboxylic acid; prostaglandins Falpha	abortifacient; antiglaucoma drug; antihypertensive agent; female contraceptive drug; prostaglandin receptor agonist

Condition	Relationship Strength	Studies
Glaucoma An ocular disease, occurring in many forms, having as its primary characteristics an unstable or a sustained increase in the intraocular pressure which the eye cannot withstand without damage to its structure or impairment of its function. The consequences of the increased pressure may be manifested in a variety of symptoms, depending upon type and severity, such as excavation of the optic disk, hardness of the eyeball, corneal anesthesia, reduced visual acuity, seeing of colored halos around lights, disturbed dark adaptation, visual field defects, and headaches. (Dictionary of Visual Science, 4th ed)	2.01	1
Intraocular Pressure The pressure of the fluids in the eye.	2.42	2
Muscle Contraction A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.	2.7	3
Vasomotor Rhinitis [description not available]	1.95	1
Rhinitis, Vasomotor A form of non-allergic rhinitis that is characterized by nasal congestion and posterior pharyngeal drainage.	1.95	1

17-phenylprostaglandin f2alpha

Description

Cross-References

Synonyms (5)

Research

Studies (7)

Market Indicators

Research Demand Index: 12.37

Study Types