17-dihydroequilenin profile

17-dihydroequilenin (17β-dihydroequilenin) is a synthetic estrogen compound that has been studied for its potential therapeutic effects.

Here's why it's important for research:

* **Potential for Menopausal Symptom Relief:** Like other estrogens, 17-dihydroequilenin has shown promise in alleviating menopausal symptoms such as hot flashes, night sweats, and vaginal dryness. It might have a favorable profile compared to some other estrogen therapies due to its potential lower risk of certain side effects.
* **Anti-Cancer Activity:** 17-dihydroequilenin has been investigated for its anti-cancer properties, particularly against breast and prostate cancer. It has shown potential in inhibiting the growth of cancer cells and may even have synergistic effects when combined with other therapies.
* **Bone Health:** Estrogen plays a crucial role in bone health, and 17-dihydroequilenin, like other estrogens, has been studied for its potential to improve bone density and reduce the risk of osteoporosis.
* **Neuroprotective Effects:** There is some evidence that 17-dihydroequilenin might have neuroprotective effects, potentially reducing the risk of cognitive decline and Alzheimer's disease.
* **Cardiovascular Health:** Research is ongoing to determine if 17-dihydroequilenin could offer cardiovascular benefits, potentially lowering the risk of heart disease and stroke.

**Important Considerations:**

* **Safety and Side Effects:** Although promising, it's essential to recognize that 17-dihydroequilenin, like other estrogens, can have potential side effects. More research is needed to fully understand its safety profile and potential risks.
* **Dosage and Administration:** The appropriate dosage and administration route of 17-dihydroequilenin for therapeutic purposes are still under investigation.
* **Ethical Considerations:** Research involving 17-dihydroequilenin, like any other drug development, should be conducted with ethical considerations in mind, including informed consent and appropriate risk management.

Overall, 17-dihydroequilenin is an interesting compound with potential therapeutic applications. Further research is needed to validate its efficacy, safety, and optimal use in treating various conditions.

17-dihydroequilenin: RN given refers to (17 beta)-isomer [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	3032407
CHEMBL ID	123405
SCHEMBL ID	1395880
MeSH ID	M0114341

Synonym
1423-97-8
beta-dihydroequilenina
beta-dihydroequilenina [spanish]
einecs 215-835-8
beta-dihydroequilenin
beta-estra-1,3,5,7,9-pentaen-3,17-diol
estra-1,3,5,7,9-pentaene-3,17beta-diol
17-dihydroequilenin
CHEMBL123405
(13s,14s,17s)-13-methyl-11,12,14,15,16,17-hexahydrocyclopenta[a]phenanthrene-3,17-diol
SCHEMBL1395880
17beta-dihydroequilenin
DTXSID40931405
(1s,3as,11as)-11a-methyl-1h,2h,3h,3ah,10h,11h,11ah-cyclopenta[a]phenanthrene-1,7-diol

Excerpt	Reference	Relevance
" The mean half-life of the slower component of equilin sulfate is 190 +/- 23 min, and the mean MCR is 176 +/- 44 liters/day ."	( Pharmacokinetics of equilin and equilin sulfate in normal postmenopausal women and men. Benoit, H; Bhavnani, BR; Wong, T; Woolever, CA, 1983)	0.27

Assay ID	Title	Year	Journal	Article
AID68899	Estrogen receptor (ER) binding affinity	1997	Journal of medicinal chemistry, Oct-24, Volume: 40, Issue:22	Induction of the estrogen specific mitogenic response of MCF-7 cells by selected analogues of estradiol-17 beta: a 3D QSAR study.
AID103554	Growth response in cultures of MCF-7 (human breast cancer cell line) cells	1997	Journal of medicinal chemistry, Oct-24, Volume: 40, Issue:22	Induction of the estrogen specific mitogenic response of MCF-7 cells by selected analogues of estradiol-17 beta: a 3D QSAR study.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	3 (33.33)	18.7374
1990's	5 (55.56)	18.2507
2000's	1 (11.11)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	9 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
estriol hormonin: estrogen replacement; each tablet contains 600 ug micronized 17beta-estradiol, 270 ug estriol and 1.4 mg estrone. chlorapatite : A phosphate mineral with the formula Ca5(PO4)3Cl.	1.99	1	16alpha-hydroxy steroid; 17beta-hydroxy steroid; 3-hydroxy steroid	estrogen; human metabolite; human xenobiotic metabolite; mouse metabolite
estrone Hydroxyestrones: Estrone derivatives substituted with one or more hydroxyl groups in any position. They are important metabolites of estrone and other estrogens.	2.4	2	17-oxo steroid; 3-hydroxy steroid; phenolic steroid; phenols	antineoplastic agent; bone density conservation agent; estrogen; human metabolite; mouse metabolite
17-desoxyestradiol estra-1,3,5(10)-trien-3-ol : A 3-hydroxy steroid resulting from deoxygenation at position 17 of estradiol or estrone.	1.99	1	3-hydroxy steroid; phenolic steroid; phenols	estrogen
androstenedione Androstenedione: A delta-4 C19 steroid that is produced not only in the TESTIS, but also in the OVARY and the ADRENAL CORTEX. Depending on the tissue type, androstenedione can serve as a precursor to TESTOSTERONE as well as ESTRONE and ESTRADIOL.. androst-4-ene-3,17-dione : A 3-oxo Delta(4)-steroid that is androst-4-ene substituted by oxo groups at positions 3 and 17. It is a steroid hormone synthesized in the adrenal glands and gonads.	1.98	1	17-oxo steroid; 3-oxo-Delta(4) steroid; androstanoid	androgen; Daphnia magna metabolite; human metabolite; mouse metabolite
formestane [no description available]	1.98	1	17-oxo steroid; 3-oxo-Delta(4) steroid; enol; hydroxy steroid	antineoplastic agent; EC 1.14.14.14 (aromatase) inhibitor
dihydroequilin dihydroequilin: RN given refers to (17alpha)-isomer	2.89	4
5 alpha-androstane-3 alpha,17 beta-diol 5alpha-androstane-3alpha,17beta-diol : The 5alpha-stereoisomer of androstane-3alpha,17beta-diol.	1.99	1	androstane-3alpha,17beta-diol	Daphnia magna metabolite; human metabolite
3,4,3',4'-tetrachlorobiphenyl 3,4,3',4'-tetrachlorobiphenyl: RN given refers to parent cpd. 3,3',4,4'-tetrachlorobiphenyl : A tetrachlorobiphenyl that is biphenyl in which the hydrogens at position 3 and 4 on each phenyl group are replaced by chlorines.	2	1	dichlorobenzene; tetrachlorobiphenyl
6-ketoestradiol [no description available]	1.99	1
estradiol-16 estradiol-16: RN given refers to the (16alpha)-isomer; RN for cpd without isomeric designation not avail 3/90	1.99	1
alfatradiol alfatradiol: used for treating androgenetic alopecia. 17alpha-estradiol : An estradiol that is estra-1,3,5(10)-triene substituted by hydroxy groups at positions 3 and 17 (the 17alpha stereoisomer).	1.99	1	17alpha-hydroxy steroid; 3-hydroxy steroid; estradiol	estrogen; geroprotector
1,3,5(10)-estratriene [no description available]	1.99	1
equilin sulfate equilin sulfate: major component of premarin; RN given refers to parent cpd	2.66	3
equilin Equilin: An estrogenic steroid produced by HORSES. It has a total of four double bonds in the A- and B-ring. High concentration of euilin is found in the URINE of pregnant mares.	2.89	4	17-oxo steroid; 3-hydroxy steroid
5 alpha-androstane-3 beta,17 beta-diol 5alpha-androstane-3beta,17beta-diol : An androstane-3,17-diol that is 5alpha-androstane substituted by beta-hydroxy groups at positions 3 and 17. It is a metabolite of dihydrotestosterone.	1.99	1	17beta-hydroxy steroid; 3beta-hydroxy steroid; androstane-3,17-diol	Daphnia magna metabolite; human metabolite
equilenin Equilenin: An estrogenic steroid produced by HORSES. It has a total of five double bonds in the A- and B-ring. High concentration of equilenin is found in the URINE of pregnant mares.. equilenin : A 3-hydroxy steroid that is estrone which carries two double bonds at positions 6 and 8. It is found in the urine of pregnant mare's and extensively used for estrogen replacement therapy in postmenopausal women.	3.48	8	17-oxo steroid; 3-hydroxy steroid	antioxidant; mammalian metabolite
17-ketosteroids 17-Ketosteroids: Steroids that contain a ketone group at position 17.. 17-oxo steroid : Any oxo steroid carrying the oxo group at position 17.	2.66	3
6alpha-hydroxy-17beta-estradiol 6alpha-hydroxy-17beta-estradiol : A 4-hydroxy steroid that consists of 17beta-estradiol bearing an additional 6alpha-hydroxy substituent.	1.99	1	6alpha-hydroxy steroid
dimyristoylphosphatidylcholine 1,2-di-O-myristoyl-sn-glycero-3-phosphocholine : A 1,2-diacyl-sn-glycero-3-phosphocholine where the two phosphatidyl acyl groups are specified as tetradecanoyl (myristoyl).. dimyristoyl phosphatidylcholine : A phosphatidylcholine where the phosphatidyl acyl groups are specified as tetradecanoyl (myristoyl).	1.96	1	1,2-diacyl-sn-glycero-3-phosphocholine; phosphatidylcholine 28:0; tetradecanoate ester	antigen; mouse metabolite
endothelin-1 Endothelin-1: A 21-amino acid peptide produced in a variety of tissues including endothelial and vascular smooth-muscle cells, neurons and astrocytes in the central nervous system, and endometrial cells. It acts as a modulator of vasomotor tone, cell proliferation, and hormone production. (N Eng J Med 1995;333(6):356-63)	2	1

Condition	Relationship Strength	Studies
Breast Cancer [description not available]	2.4	2
Breast Neoplasms Tumors or cancer of the human BREAST.	2.4	2
Menopause The last menstrual period. Permanent cessation of menses (MENSTRUATION) is usually defined after 6 to 12 months of AMENORRHEA in a woman over 45 years of age. In the United States, menopause generally occurs in women between 48 and 55 years of age.	2.37	2
Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	2	1

17-dihydroequilenin

Description

Cross-References

Synonyms (14)

Research Excerpts

Pharmacokinetics

Bioassays (2)

Research

Studies (9)

Market Indicators

Research Demand Index: 12.03

Study Types