## 16-O-methylcafestol: A Coffee Component with Potential Health Implications
**16-O-methylcafestol (16-OMC)** is a **fatty acid ester** found in **unfiltered coffee** like brewed coffee. It's a **lipid** compound, meaning it's soluble in fats and oils, and is one of the main components of coffee oils.
**Why is it important for research?**
16-OMC has garnered significant interest due to its potential **biological effects**, specifically its influence on **lipid metabolism** and **cardiovascular health**.
**Here's what researchers are investigating about 16-OMC:**
* **Impact on Cholesterol Levels:** Studies have shown that 16-OMC can **elevate LDL (bad) cholesterol** levels and **decrease HDL (good) cholesterol** levels, potentially increasing the risk of cardiovascular diseases. However, the results are not conclusive, and further research is needed to understand the mechanisms and long-term effects.
* **Influence on Liver Function:** Research suggests that 16-OMC might **impair liver function** by interfering with the production of bile acids, which are essential for fat digestion. This could contribute to various liver health issues.
* **Antioxidant Properties:** Some studies have explored 16-OMC's potential antioxidant properties. While it demonstrates antioxidant activity in laboratory settings, its actual impact on the body requires further investigation.
* **Interactions with Other Compounds:** Researchers are investigating how 16-OMC interacts with other compounds present in coffee, such as caffeine, and how these interactions affect its biological effects.
* **Potential Therapeutic Uses:** Despite the potential negative effects, some studies are exploring the possibility of using 16-OMC for its anti-inflammatory and anti-cancer properties.
**Key Takeaways:**
* 16-OMC is a significant compound in unfiltered coffee.
* Its potential impact on lipid metabolism, cholesterol levels, and liver function is a primary focus of research.
* Further studies are needed to clarify the complex effects of 16-OMC on human health.
**In summary, 16-O-methylcafestol is a vital research subject due to its potential influence on various aspects of human health, particularly cardiovascular health and liver function. Understanding its effects is crucial for informing public health recommendations and guiding future research in the field of coffee consumption and health.**
16-O-methylcafestol: constituent of coffee; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 68103163 |
| SCHEMBL ID | 10307383 |
| MeSH ID | M000608773 |
| Synonym |
|---|
| 108214-28-4 |
| 16-o-methylcafestol |
| SCHEMBL10307383 |
| DTXSID30737953 |
| [(3bs,5as,7r,8r,10ar,10bs)-7-methoxy-10b-methyl-3b,4,5,6,7,8,9,10,10a,10b,11,12-dodecahydro-5a,8-methanocyclohepta[5,6]naphtho[2,1-b]furan-7-yl]methanol |
| J-002074 |
| 16-o-methylcafestol, analytical standard |
| (3bs,5as,7r,8r,10ar,10bs)- 7-methoxy-10b-methyl-3b,4,5,6,7,8,9,10,10a,10b,11,12-dodecahydro-5a,8-methano- 5ah-cycloheptal[5,6]naphtho[2,1-b]furan-7-methanol |
| [(1s,4s,12s,13r,16r,17r)-17-methoxy-12-methyl-8-oxapentacyclo[14.2.1.01,13.04,12.05,9]nonadeca-5(9),6-dien-17-yl]methanol |
| Q15220829 |
| 16-o-methyl-cafestol |
| [(1s,4s,12s,13r,16r,17r)-17-methoxy-12-methyl-8-oxapentacyclo[14.2.1.0{1,13}.0{4,12}.0{5,9}]nonadeca-5(9),6-dien-17-yl]methanol |
| PD043748 |
| F86482 |
| (3bs,5as,7r,8r,10ar,10bs)-3b,4,5,6,7,8,9,10,10a,10b,11,12-dodecahydro-7-methoxy-10b-methyl-5a,8-methano-5ah-cyclohepta(5,6)naphtho(2,1-b)furan-7-methanol |
| unii-tj95s36bvx |
| tj95s36bvx , |
| 5a,8-methano-5ah-cyclohepta(5,6)naphtho(2,1-b)furan-7-methanol, 3b,4,5,6,7,8,9,10,10a,10b,11,12-dodecahydro-7-methoxy-10b-methyl-, (3bs,5as,7r,8r,10ar,10bs)- |
| ((1s,4s,12s,13r,16r,17r)-17-methoxy-12-methyl-8-oxapentacyclo(14.2.1.0(1,13).0(4,12).0(5,9))nonadeca-5(9),6-dien-17-yl)methanol |
| CS-0063695 |
| HY-116056 |
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (62.50) | 24.3611 |
| 2020's | 3 (37.50) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (28.00) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 8 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||