Page last updated: 2024-12-08
16-fluoropalmitic acid
Description
## 16-Fluoropalmitic Acid: A Powerful Tool for Research
16-Fluoropalmitic acid (16-FPA) is a synthetic fatty acid that serves as a valuable tool in research, particularly in the fields of **lipid metabolism, cell signaling, and drug development**. Here's why it's important:
**1. A Powerful Analog of Palmitic Acid:**
* 16-FPA is a structural analog of palmitic acid, a common saturated fatty acid found in many organisms.
* The key difference is the **replacement of a hydrogen atom at the 16th carbon position with a fluorine atom**.
**2. Unique Properties & Applications:**
* **Increased Metabolic Stability:** The fluorine atom makes 16-FPA more resistant to enzymatic breakdown compared to palmitic acid. This allows it to linger longer in the system, providing a more prolonged effect.
* **Altered Binding Affinity:** The fluorine atom can influence the binding affinity of 16-FPA to various proteins and receptors, potentially altering their function. This makes it useful for studying protein-lipid interactions.
* **Metabolic Tracers:** 16-FPA can be used as a tracer to follow the metabolic pathways of fatty acids, providing insights into lipid metabolism and its regulation.
* **Drug Development:** 16-FPA's properties can be exploited in drug development, for example, to:
* **Inhibit fatty acid synthesis:** by interfering with enzymes like fatty acid synthase.
* **Modify cell membrane properties:** impacting cell signaling and function.
* **Develop novel therapeutics:** targeting specific pathways related to lipid metabolism and cell signaling.
**3. Research Areas of Interest:**
* **Cancer Research:** 16-FPA has shown potential in inhibiting tumor growth and promoting apoptosis in some studies.
* **Neurological Disorders:** It's being investigated for its potential role in regulating neuronal function and potentially treating neurological disorders.
* **Inflammation and Immunity:** The fluorine modification can influence immune cell function and inflammation processes.
* **Metabolic Diseases:** 16-FPA may be useful in studying and potentially treating metabolic disorders like obesity and diabetes.
**Overall:**
16-Fluoropalmitic acid serves as a powerful tool for researchers to study the complex roles of lipids in biological systems. Its unique properties and applications offer valuable insights into lipid metabolism, cell signaling, and drug development, paving the way for future advancements in these fields.
16-fluoropalmitic acid: RN given refers to unlabeled cpd [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
| ID Source | ID |
|---|
| PubMed CID | 151081 |
| CHEBI ID | 34164 |
| SCHEMBL ID | 7221658 |
| MeSH ID | M0098363 |
Synonyms (12)
| Synonym |
|---|
| 3109-58-8 |
| 16-fluoro-hexadecanoic acid |
| hexadecanoic acid, 16-fluoro- |
| LMFA01090034 |
| 16-fluoropalmitic acid |
| 16-fluorohexadecanoic acid |
| fpa-16 |
| 16-fluoropalmitate |
| SCHEMBL7221658 |
| CHEBI:34164 |
| DTXSID30185036 |
| Q27115858 |
Drug Classes (2)
| Class | Description |
|---|
| long-chain fatty acid | A fatty acid with a chain length ranging from C13 to C22. |
| fluoro fatty acid | Any halo fatty acid containing at least one fluoro substituent. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] |
Research
Studies (4)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|
| pre-1990 | 1 (25.00) | 18.7374 |
| 1990's | 2 (50.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Market Indicators
Research Demand Index: 12.66
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| Metric | This Compound (vs All) |
|---|
| Research Demand Index | 12.66 (24.57) | | Research Supply Index | 1.79 (2.92) | | Research Growth Index | 4.45 (4.65) | | Search Engine Demand Index | 0.00 (26.88) | | Search Engine Supply Index | 0.00 (0.95) |
| |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 5 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |