Compounds > 16-fluoroestradiol, (16alpha,17beta)-isomer
Page last updated: 2024-11-12

16-fluoroestradiol, (16alpha,17beta)-isomer

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Cross-References

ID SourceID
PubMed CID10401972
CHEMBL ID1627367
SCHEMBL ID6543568
MeSH IDM0321909

Synonyms (18)

Synonym
16.alpha.-fluoroestradiol
fluoroestradiol
CHEMBL1627367
fluoroestradiol, 16.alpha.-
16alpha-fluoroestradiol
SCHEMBL6543568
16alpha-fluoro-17beta-estradiol
92817-10-2
estra-1,3,5(10)-triene-3,17-diol, 16-fluoro-, (16.alpha.,17.beta.)-
16.alpha.-fluoro-13.beta.-methyl-1,3,5(10)-gonatriene-3,17.beta.-diol
LVI5P34A3C ,
16.alpha.-fluoro-17.beta.-estradiol
(8r,9s,13s,14s,16r,17r)-16-fluoro-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol
fluoroestradiol, 16alpha-
unii-lvi5p34a3c
estra-1,3,5(10)-triene-3,17-diol, 16-fluoro-, (16alpha,17beta)-
16alpha-fluoro-13beta-methyl-1,3,5(10)-gonatriene-3,17beta-diol
DTXSID401027871
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (114)

Assay IDTitleYearJournalArticle
AID253980Biodistribution of [18F]FES in beta estrogen receptor knock out mouse liver after 1 h; (n=3)2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID254128Biodistribution of [18F]FES in beta estrogen receptor knock out mouse liver after 30 min(n=2); mice in nonestrus stage2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID253988Biodistribution of [18F]FES in alpha estrogen receptor knock out mouse blood after 1 h; (n=3)2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID254005Biodistribution of [18F]FES in beta estrogen receptor knock out mouse uterus after 1 h; (n=3)2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID253977Biodistribution of [18F]FES in beta estrogen receptor knock out mouse brain after 2 h; (n=3)2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID254024Biodistribution of [18F]FES in alpha estrogen receptor knock out mouse spleen after 1 h; (n=3)2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID254141Biodistribution of [18F]FES in beta estrogen receptor knock out mouse uterus after 30 min(n=2); mice in nonestrus stage2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID253989Biodistribution of [18F]FES in alpha estrogen receptor knock out mouse blood after 2 h; (n=3)2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID254148Biodistribution of [18F]FES in beta estrogen receptor knock out mouse ovaries after 30 min(n=2); mice in nonestrus stage2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID253973Biodistribution of [18F]FES in alpha estrogen receptor knock out mouse lung after 2 h; (n=3)2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID255172Ratio of [18F]FES uptake in ovaries of ERbeta KO-mouse (estrus) and ERalpha KO-mouse (nonestrus) after 1 hr2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID253965Biodistribution of [18F]FES in beta estrogen receptor knock out mouse bone after 2 h; (n=3)2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID254138Biodistribution of [18F]FES in beta estrogen receptor knock out mouse muscle after 30 min(n=2); mice in nonestrus stage2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID254125Biodistribution of [18F]FES in beta estrogen receptor knock out mouse blood after 30 min(n=2); mice in nonestrus stage2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID253966Biodistribution of [18F]FES in beta estrogen receptor knock out mouse lung after 1 h; (n=3)2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID253993Biodistribution of [18F]FES in alpha estrogen receptor knock out mouse heart after 2 h; (n=3)2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID254019Biodistribution of [18F]FES in alpha estrogen receptor knock out mouse fat after 30 min; (n=3)2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID203785Binding affinity against Sex steroid binding protein(SBP) of human serum1990Journal of medicinal chemistry, Dec, Volume: 33, Issue:12
11 beta-methoxy-, 11 beta-ethyl- and 17 alpha-ethynyl-substituted 16 alpha-fluoroestradiols: receptor-based imaging agents with enhanced uptake efficiency and selectivity.
AID253976Biodistribution of [18F]FES in beta estrogen receptor knock out mouse brain after 1 h; (n=3)2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID254083Biodistribution of [18F]FES in beta estrogen receptor knock out mouse thymus after 30 min; (n=3)2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID254033Biodistribution of [18F]FES in beta estrogen receptor knock out mouse ovaries after 2 h; (n=3)2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID255183Ratio of [18F]FES uptake in uterus of ERbeta KO-mouse (estrus) and ERalpha KO-mouse (nonestrus) after 30 min2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID255186Ratio of [18F]-FES uptake in ovaries of ERbeta KO-mouse (estrus) and ERalpha KO-mouse (nonestrus) after 2 hr with [18F]FEDPN2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID254079Biodistribution of [18F]FES in alpha estrogen receptor knock out mouse liver after 30 min; (n=3)2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID254095Biodistribution of [18F]FES in alpha estrogen receptor knock out mouse spleen after 30 min; (n=3)2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID254094Biodistribution of [18F]FES in alpha estrogen receptor knock out mouse muscle after 30 min; (n=3)2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID254021Biodistribution of [18F]-FES in alpha estrogen receptor knock out mouse kidney after 2 h; (n=3)2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID254003Biodistribution of [18F]-FES in beta estrogen receptor knock out mouse thymus after 1 h; (n=3)2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID253991Biodistribution of [18F]-FES in alpha estrogen receptor knock out mouse brain after 2 h; (n=3)2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID253995Biodistribution of [18F]FES in alpha estrogen receptor knock out mouse liver after 2 h; (n=3)2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID253997Biodistribution of [18F]FES in beta estrogen receptor knock out mouse kidney after 1 h; (n=3)2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID254096Biodistribution of [18F]-FES in alpha estrogen receptor knock out mouse thymus after 30 min; (n=3)2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID254030Biodistribution of [18F]FES in beta estrogen receptor knock out mouse bone after 30 min; (n=3)2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID254575Relative binding affinity towards human estrogen receptor alpha using [3H]estradiol upon incubation at 0 degree C for 18-24 h; [RBA E2 = 100]2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID39321Relative binding affinity (RBA) against androgen receptor (AR) using [3H]R-1881 as competitive radioligand.1992Journal of medicinal chemistry, May-29, Volume: 35, Issue:11
Synthesis of high affinity fluorine-substituted ligands for the androgen receptor. Potential agents for imaging prostatic cancer by positron emission tomography.
AID254117Biodistribution of [18F]-FES in beta estrogen receptor knock out mouse bone after 30 min(n=2); mice in nonestrus stage2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID253974Biodistribution of [18F]FES in beta estrogen receptor knock out mouse blood after 1 h; (n=3)2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID255177Ratio of [18F]-FES uptake in uterus of ERbeta KO-mouse (estrus) and ERalpha KO-mouse (nonestrus) after 2 hr2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID254126Biodistribution of [18F]FES in beta estrogen receptor knock out mouse brain after 30 min(n=2); mice in nonestrus stage2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID254004Biodistribution of [18F]FES in beta estrogen receptor knock out mouse thymus after 2 h; (n=3)2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID255185Ratio of [18F]-FES uptake in ovaries of ERbeta KO-mouse (estrus) and ERalpha KO-mouse (nonestrus) after 1 hr with [18F]FEDPN2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID254127Biodistribution of [18F]FES in beta estrogen receptor knock out mouse heart after 30 min(n=2); mice in nonestrus stage2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID255176Ratio of [18F]FES uptake in uterus of ERbeta KO-mouse (estrus) and ERalpha KO-mouse (nonestrus) after 1 hr2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID254078Biodistribution of [18F]FES in alpha estrogen receptor knock out mouse heart after 30 min; (n=3)2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID254139Biodistribution of [18F]FES in beta estrogen receptor knock out mouse spleen after 30 min(n=2); mice in nonestrus stage2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID253978Biodistribution of [18F]FES in beta estrogen receptor knock out mouse heart after 1 h; (n=3)2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID254077Biodistribution of [18F]FES in alpha estrogen receptor knock out mouse brain after 30 min; (n=3)2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID254080Biodistribution of [18F]FES in beta estrogen receptor knock out mouse kidney after 30 min; (n=3)2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID254026Biodistribution of [18F]FES in alpha estrogen receptor knock out mouse thymus after 1 h; (n=3)2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID254084Biodistribution of [18F]FES in beta estrogen receptor knock out mouse uterus after 30 min; (n=3)2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID254116Biodistribution of [18F]FES in beta estrogen receptor knock out mouse fat after 30 min(n=2); mice in nonestrus stage2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID254097Biodistribution of [18F]FES in alpha estrogen receptor knock out mouse uterus after 30 min; (n=3)2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID254027Biodistribution of [18F]FES in alpha estrogen receptor knock out mouse thymus after 2 h; (n=3)2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID254053Biodistribution of [18F]-FES in alpha estrogen receptor knock out mouse bone after 30 min; (n=3)2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID255187Ratio of [18F]FES uptake in uterus of ERbeta KO-mouse (estrus) and ERalpha KO-mouse (nonestrus) after 1 hr with [18F]-FEDPN2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID69394Binding affinity against estrogen receptor at 0C1990Journal of medicinal chemistry, Dec, Volume: 33, Issue:12
11 beta-methoxy-, 11 beta-ethyl- and 17 alpha-ethynyl-substituted 16 alpha-fluoroestradiols: receptor-based imaging agents with enhanced uptake efficiency and selectivity.
AID253970Biodistribution of [18F]FES in alpha estrogen receptor knock out mouse bone after 1 h; (n=3)2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID254022Biodistribution of [18F]-FES in alpha estrogen receptor knock out mouse muscle after 1 h; (n=3)2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID254029Biodistribution of [18F]FES in alpha estrogen receptor knock out mouse uterus after 2 h; (n=3)2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID255173Ratio of [18F]FES uptake in ovaries of ERbeta KO-mouse (estrus) and ERalpha KO-mouse (nonestrus) after 2 hr2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID253981Biodistribution of [18F]FES in beta estrogen receptor knock out mouse liver after 2 h; (n=3)2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID253990Biodistribution of [18F]FES in alpha estrogen receptor knock out mouse brain after 1 h; (n=3)2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID255188Ratio of [18F]FES uptake in uterus of ERbeta KO-mouse (estrus) and ERalpha KO-mouse (nonestrus) after 2 hr with [18F]-FEDPN2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID254058Biodistribution of [18F]-FES in beta estrogen receptor knock out mouse brain after 30 min; (n=3)2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID35536Binding affinity against Alphafetoprotein (AFP), in rodents.1990Journal of medicinal chemistry, Dec, Volume: 33, Issue:12
11 beta-methoxy-, 11 beta-ethyl- and 17 alpha-ethynyl-substituted 16 alpha-fluoroestradiols: receptor-based imaging agents with enhanced uptake efficiency and selectivity.
AID254002Biodistribution of [18F]FES in beta estrogen receptor knock out mouse spleen after 2 h; (n=3)2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID253998Biodistribution of [18F]FES in beta estrogen receptor knock out mouse kidney after 2 h; (n=3)2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID255179Ratio of [18F]FES uptake in ovaries of ERbeta KO-mouse (estrus) and ERalpha KO-mouse (nonestrus) after 30 min2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID253975Biodistribution of [18F]FES in beta estrogen receptor knock out mouse blood after 2 h; (n=3)2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID69543Relative binding affinity for estrogen receptor from immature rat uterus1991Journal of medicinal chemistry, May, Volume: 34, Issue:5
Synthesis and biological activity of new halo-steroidal antiestrogens.
AID254057Biodistribution of [18F]FES in beta estrogen receptor knock out mouse blood after 30 min; (n=3)2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID254140Biodistribution of [18F]FES in beta estrogen receptor knock out mouse thymus after 30 min(n=2); mice in nonestrus stage2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID254023Biodistribution of [18F]FES in alpha estrogen receptor knock out mouse muscle after 2 h; (n=3)2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID254055Biodistribution of [18F]FES in alpha estrogen receptor knock out mouse ovaries after 1 h; (n=3)2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID254098Biodistribution of [18F]FES in beta estrogen receptor knock out mouse ovaries after 30 min; (n=3)2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID253996Biodistribution of [18F]FES in beta estrogen receptor knock out mouse fat after 30 min; (n=3)2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID254081Biodistribution of [18F]FES in beta estrogen receptor knock out mouse muscle after 30 min; (n=3)2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID254032Biodistribution of [18F]FES in beta estrogen receptor knock out mouse ovaries after 1 h; (n=3)2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID254001Biodistribution of [18F]FES in beta estrogen receptor knock out mouse spleen after 1 h; (n=3)2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID253959Biodistribution of [18F]FES in beta estrogen receptor knock out mouse fat after 1 h; (n=3)2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID253992Biodistribution of [18F]FES in alpha estrogen receptor knock out mouse heart after 1 h; (n=3)2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID254025Biodistribution of [18F]FES in alpha estrogen receptor knock out mouse spleen after 2 h; (n=3)2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID254054Biodistribution of [18F]FES in alpha estrogen receptor knock out mouse lung after 30 min; (n=3)2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID253994Biodistribution of [18F]-FES in alpha estrogen receptor knock out mouse liver after 1 h; (n=3)2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID253963Biodistribution of [18F]FES in alpha estrogen receptor knock out mouse fat after 2 h; (n=3)2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID254028Biodistribution of [18F]FES in alpha estrogen receptor knock out mouse uterus after 1 h; (n=3)2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID254093Biodistribution of [18F]FES in alpha estrogen receptor knock out mouse kidney after 30 min; (n=3)2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID253967Biodistribution of [18F]-FES in beta estrogen receptor knock out mouse lung after 2 h; (n=3)2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID254118Biodistribution of [18F]FES in beta estrogen receptor knock out mouse lung after 30 min(n=2); mice in nonestrus stage2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID254082Biodistribution of [18F]FES in beta estrogen receptor knock out mouse spleen after 30 min; (n=3)2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID253999Biodistribution of [18F]FES in beta estrogen receptor knock out mouse muscle after 1 h; (n=3)2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID253962Biodistribution of [18F]FES in alpha estrogen receptor knock out mouse fat after 1 h; (n=3)2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID255189Ratio of [18F]FES uptake in ovaries of ERbeta KO-mouse (estrus) and ERalpha KO-mouse (nonestrus) after 30 min with [18F]-FEDPN2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID253972Biodistribution of [18F]FES in alpha estrogen receptor knock out mouse lung after 1 h; (n=3)2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID69396Binding affinity against estrogen receptor at 25 degree C1990Journal of medicinal chemistry, Dec, Volume: 33, Issue:12
11 beta-methoxy-, 11 beta-ethyl- and 17 alpha-ethynyl-substituted 16 alpha-fluoroestradiols: receptor-based imaging agents with enhanced uptake efficiency and selectivity.
AID255190Ratio of [18F]-FES uptake in uterus of ERbeta KO-mouse (estrus) and ERalpha KO-mouse (nonestrus) after 30 min with [18F]FEDPN2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID254006Biodistribution of [18F]FES in beta estrogen receptor knock out mouse uterus after 2 h; (n=3)2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID254137Biodistribution of [18F]FES in beta estrogen receptor knock out mouse kidney after 30 min(n=2); mice in nonestrus stage2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID254020Biodistribution of [18F]FES in alpha estrogen receptor knock out mouse kidney after 1 h; (n=3)2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID254056Biodistribution of [18F]FES in alpha estrogen receptor knock out mouse ovaries after 2 h; (n=3)2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID253979Biodistribution of [18F]FES in beta estrogen receptor knock out mouse heart after 2 h; (n=3)2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID253971Biodistribution of [18F]-FES in alpha estrogen receptor knock out mouse bone after 2 h; (n=3)2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID255381Absolute ratio of relative binding affinity towards human ER beta to human ER alpha2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID253964Biodistribution of [18F]FES in beta estrogen receptor knock out mouse bone after 1 h; (n=3)2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID255163Ratio of relative binding affinity towards human ER beta to human ER alpha2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID254060Biodistribution of [18F]FES in beta estrogen receptor knock out mouse liver after 30 min; (n=3)2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID254574Relative binding affinity for human estrogen receptor beta using [3H]estradiol upon incubation at 0 degree C for 18-24 h; [RBA E2 = 100]2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID69674Relative binding affinity for rat uterine estrogen receptor at 25 degree C1990Journal of medicinal chemistry, Dec, Volume: 33, Issue:12
Synthesis and estrogen receptor binding of novel 11 beta-substituted estra-1,3,5(10)-triene-3,17 beta-diols.
AID254031Biodistribution of [18F]FES in beta estrogen receptor knock out mouse lung after 30 min; (n=3)2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID254108Biodistribution of [18F]FES in alpha estrogen receptor knock out mouse ovaries after 30 min; (n=3)2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID254076Biodistribution of [18F]FES in alpha estrogen receptor knock out mouse blood after 30 min; (n=3)2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID253960Biodistribution of [18F]FES in beta estrogen receptor knock out mouse fat after 2 h; (n=3)2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID254059Biodistribution of [18F]-FES in beta estrogen receptor knock out mouse heart after 30 min; (n=3)2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
AID254000Biodistribution of [18F]FES in beta estrogen receptor knock out mouse muscle after 2 h; (n=3)2005Journal of medicinal chemistry, Oct-06, Volume: 48, Issue:20
Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's4 (80.00)18.2507
2000's1 (20.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.40

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.40 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.20 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.40)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
ethinyl estradiol
Ethinyl Estradiol: A semisynthetic alkylated ESTRADIOL with a 17-alpha-ethinyl substitution. It has high estrogenic potency when administered orally, and is often used as the estrogenic component in ORAL CONTRACEPTIVES.. 17alpha-ethynylestradiol : A 3-hydroxy steroid that is estradiol substituted by a ethynyl group at position 17. It is a xenoestrogen synthesized from estradiol and has been shown to exhibit high estrogenic potency on oral administration.		1.971017-hydroxy steroid;
3-hydroxy steroid;
terminal acetylenic compound		xenoestrogen
nandrolone
Nandrolone: C18 steroid with androgenic and anabolic properties. It is generally prepared from alkyl ethers of ESTRADIOL to resemble TESTOSTERONE but less one carbon at the 19 position.. nandrolone : A 3-oxo Delta(4)-steroid that is estr-4-en-3-one substituted by a beta-hydroxy group at position 17.		1.981017beta-hydroxy steroid;
3-oxo-Delta(4) steroid;
anabolic androgenic steroid		human metabolite
dihydrotestosterone
Dihydrotestosterone: A potent androgenic metabolite of TESTOSTERONE. It is produced by the action of the enzyme 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE.. 17beta-hydroxyandrostan-3-one : A 17beta-hydroxy steroid that is testosterone in which the 4-5 double bond has been reduced to a single bond with unspecified configuration at position 5.. 17beta-hydroxy-5alpha-androstan-3-one : A 17beta-hydroxy steroid that is testosterone in which the 4,5 double bond has been reduced to a single bond with alpha-configuration at position 5.		1.981017beta-hydroxy steroid;
17beta-hydroxyandrostan-3-one;
3-oxo-5alpha-steroid		androgen;
Daphnia magna metabolite;
human metabolite;
mouse metabolite
16-fluoroestradiol
16-fluoroestradiol: RN refers to (16beta,17beta)-isomer		1.9810
ici 164384
ICI 164384: structure given in first source. ICI-164384 : A 3-hydroxy steroid that is 17beta-estradiol substituted by a 11-[butyl(methyl)amino]-11-oxoundecyl group at position 7R. It is a steroidal antioestrogen that inhibits the cell proliferation of breast-carcinoma cell lines.		1.971017beta-hydroxy steroid;
3-hydroxy steroid;
tertiary carboxamide		anti-estrogen;
antineoplastic agent;
estrogen receptor antagonist
em 139
EM 139: EM-170 is the (17'alpha)-isomer		1.9710
metribolone
Metribolone: A synthetic non-aromatizable androgen and anabolic steroid. It binds strongly to the androgen receptor and has therefore also been used as an affinity label for this receptor in the prostate and in prostatic tumors.. 17beta-hydroxy-17-methylestra-4,9,11-trien-3-one : A synthetic non-aromatisable androgen and anabolic steroid. It binds strongly to the androgen receptor and has therefore also been used as an affinity label for this receptor in the prostate and in prostatic tumors.		1.981017beta-hydroxy steroid;
3-oxo steroid;
anabolic androgenic steroid		androgen
tamoxifen
[no description available]		1.9710stilbenoid;
tertiary amino compound		angiogenesis inhibitor;
antineoplastic agent;
bone density conservation agent;
EC 1.2.3.1 (aldehyde oxidase) inhibitor;
EC 2.7.11.13 (protein kinase C) inhibitor;
estrogen antagonist;
estrogen receptor antagonist;
estrogen receptor modulator
ConditionIndicatedRelationship StrengthStudiesTrials
Cancer of Prostate
[description not available]		01.9810
Prostatic Neoplasms
Tumors or cancer of the PROSTATE.		01.9810