15-hydroxyeicosanoic acid profile

## 15-Hydroxyeicosanoic Acid (15-HETE)

15-HETE is a **hydroxy-derivative of arachidonic acid**, a fatty acid found in cell membranes. It is produced by the **enzyme 15-lipoxygenase (15-LOX)**, which is expressed in various tissues and cell types.

### Importance for Research:

15-HETE plays a crucial role in a wide range of biological processes, making it a significant area of research. Here are some key areas where it is being investigated:

**1. Inflammation and Immune Response:**

* **Anti-inflammatory effects:** 15-HETE has been shown to inhibit leukocyte adhesion and migration, reducing inflammation.
* **Modulation of immune cell function:** It affects the activity of T cells, macrophages, and other immune cells, potentially impacting immune responses.
* **Potential therapeutic target:** Due to its anti-inflammatory properties, 15-HETE is being studied as a potential target for treating inflammatory diseases like arthritis and asthma.

**2. Cardiovascular Health:**

* **Regulation of blood pressure:** 15-HETE can modulate vascular tone and blood pressure by influencing smooth muscle cells.
* **Atherogenesis:** Studies suggest 15-HETE may contribute to the development of atherosclerosis, a major risk factor for cardiovascular disease.
* **Potential therapeutic target:** Researchers are exploring the use of 15-HETE or its inhibitors for managing cardiovascular conditions.

**3. Cancer Research:**

* **Tumor growth and metastasis:** 15-HETE has been linked to promoting tumor growth and metastasis in certain cancers.
* **Chemoresistance:** It may contribute to chemoresistance, making cancer treatment more challenging.
* **Potential therapeutic target:** Understanding the role of 15-HETE in cancer may lead to new therapies for cancer prevention and treatment.

**4. Other Biological Processes:**

* **Neurological function:** 15-HETE is involved in neuronal signaling and neuroprotection.
* **Wound healing:** It contributes to the inflammatory response during wound healing.
* **Reproductive health:** Studies suggest a role for 15-HETE in reproductive processes.

**Further Research:**

The complex role of 15-HETE in various biological processes necessitates further research to fully understand its mechanisms and potential applications. This includes:

* **Identifying specific receptors and downstream signaling pathways involved in 15-HETE action.**
* **Developing specific inhibitors or activators of 15-LOX to modulate 15-HETE production.**
* **Investigating the potential of 15-HETE as a therapeutic target for various diseases.**

Understanding the intricate role of 15-HETE holds immense promise for advancing our knowledge in various fields of medicine, biology, and pharmacology.

15-hydroxyeicosanoic acid: structure given in first source; RN given refers to cpd without isomeric designation [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	115323
CHEBI ID	189996
MeSH ID	M0197648

Synonym
eicosanoic acid, 15-hydroxy-
15-hydroxyeicosanoic acid
73179-99-4
15-hydroxyicosanoic acid
CHEBI:189996
20:0(15-oh)
15-hydroxy-eicosanoic acid
DTXSID00993908

Class	Description
long-chain fatty acid	A fatty acid with a chain length ranging from C13 to C22.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	1 (14.29)	18.2507
2000's	3 (42.86)	29.6817
2010's	2 (28.57)	24.3611
2020's	1 (14.29)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	7 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
threonine Threonine: An essential amino acid occurring naturally in the L-form, which is the active form. It is found in eggs, milk, gelatin, and other proteins.. threonine : An alpha-amino acid in which one of the hydrogens attached to the alpha-carbon of glycine is substituted by a 1-hydroxyethyl group.	2.1	1	amino acid zwitterion; aspartate family amino acid; L-alpha-amino acid; proteinogenic amino acid; threonine	algal metabolite; Escherichia coli metabolite; human metabolite; micronutrient; mouse metabolite; nutraceutical; plant metabolite; Saccharomyces cerevisiae metabolite
fluorobenzenes Fluorobenzenes: Derivatives of BENZENE that contain FLUORINE.. monofluorobenzene : The simplest member of the class of monofluorobenzenes that is benzene carrying a single fluoro substituent.. fluorobenzenes : Any fluoroarene that is a benzene or a substituted benzene carrying at least one fluoro group.	1.97	1	monofluorobenzenes	NMR chemical shift reference compound
dihydrotestosterone Dihydrotestosterone: A potent androgenic metabolite of TESTOSTERONE. It is produced by the action of the enzyme 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE.. 17beta-hydroxyandrostan-3-one : A 17beta-hydroxy steroid that is testosterone in which the 4-5 double bond has been reduced to a single bond with unspecified configuration at position 5.. 17beta-hydroxy-5alpha-androstan-3-one : A 17beta-hydroxy steroid that is testosterone in which the 4,5 double bond has been reduced to a single bond with alpha-configuration at position 5.	2.42	2	17beta-hydroxy steroid; 17beta-hydroxyandrostan-3-one; 3-oxo-5alpha-steroid	androgen; Daphnia magna metabolite; human metabolite; mouse metabolite
pentafluorobenzyl bromide pentafluorobenzyl bromide : A member of the class benzyl bromides that is benzyl bromide in which the hydrogens at positions 2, 3, 4, 5 and 6 of the phenyl ring are replaced by fluoro groups. It is a versatile derivatization agent in chromatography and mass spectrometry.	1.97	1	benzyl bromides; fluorobenzenes
arachidonic acid icosa-5,8,11,14-tetraenoic acid : Any icosatetraenoic acid with the double bonds at positions 5, 8, 11 and 14.. arachidonate : A long-chain fatty acid anion resulting from the removal of a proton from the carboxy group of arachidonic acid.	2.42	2	icosa-5,8,11,14-tetraenoic acid; long-chain fatty acid; omega-6 fatty acid	Daphnia galeata metabolite; EC 3.1.1.1 (carboxylesterase) inhibitor; human metabolite; mouse metabolite
ovalbumin Ovalbumin: An albumin obtained from the white of eggs. It is a member of the serpin superfamily.	2.41	1
dinoprostone prostaglandin E2 : Prostaglandin F2alpha in which the hydroxy group at position 9 has been oxidised to the corresponding ketone. Prostaglandin E2 is the most common and most biologically potent of mammalian prostaglandins.	2.02	1	prostaglandins E	human metabolite; mouse metabolite; oxytocic
gamma-linolenic acid gamma-Linolenic Acid: An omega-6 fatty acid produced in the body as the delta 6-desaturase metabolite of linoleic acid. It is converted to dihomo-gamma-linolenic acid, a biosynthetic precursor of monoenoic prostaglandins such as PGE1. (From Merck Index, 11th ed). gamma-linolenic acid : A C18, omega-6 acid fatty acid comprising a linolenic acid having cis- double bonds at positions 6, 9 and 12.	2.42	2	linolenic acid; omega-6 fatty acid	human metabolite; mouse metabolite; plant metabolite
13-hydroxy-9,11-octadecadienoic acid 13-hydroxy-9,11-octadecadienoic acid: chemorepellant factor which maintains blood vessel wall thromboresistance; RN given refers to unspecified stereoisomer	2.02	1	octadecadienoic acid
4-hydroxy-2-nonenal 4-hydroxy-2-nonenal: cytotoxic product from peroxidation of liver microsomal lipids; RN given refers to cpd without isomeric designation. 4-hydroxynon-2-enal : An enal consisting of non-2-ene having an oxo group at the 1-position and a hydroxy group at the 4-position.. 4-hydroxynonenal : A monounsaturated fatty aldehyde that is nonanal that has undergone dehydrogenation to introduce a double bond at any position in the aliphatic chain and in which a hydrogen at position 4 has been replaced by a hydroxy group.	2.02	1	4-hydroxynon-2-enal; 4-hydroxynonenal
15-hydroxy-5,8,11,13-eicosatetraenoic acid 15-hydroxy-5,8,11,13-eicosatetraenoic acid: potent & selective inhibitor of platelet lipoxygenase; RN given refers to cpd without isomeric designation	2.08	1

Condition	Relationship Strength	Studies
Allergic Rhinitis [description not available]	2.41	1
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	2.49	2
Rhinitis, Allergic An inflammation of the NASAL MUCOSA triggered by ALLERGENS.	2.41	1
Cancer of Liver [description not available]	2.08	1
Invasiveness, Neoplasm [description not available]	2.08	1
Liver Neoplasms Tumors or cancer of the LIVER.	2.08	1
Adenocarcinoma, Basal Cell [description not available]	2.42	2
Cancer of Prostate [description not available]	2.42	2
Hormone-Dependent Neoplasms [description not available]	2.01	1
Adenocarcinoma A malignant epithelial tumor with a glandular organization.	2.42	2
Prostatic Neoplasms Tumors or cancer of the PROSTATE.	2.42	2
Disease Exacerbation [description not available]	2.02	1
Adenoma, Prostatic [description not available]	2.02	1
Prostatic Hyperplasia Increase in constituent cells in the PROSTATE, leading to enlargement of the organ (hypertrophy) and adverse impact on the lower urinary tract function. This can be caused by increased rate of cell proliferation, reduced rate of cell death, or both.	2.02	1

15-hydroxyeicosanoic acid

Description

Cross-References

Synonyms (8)

Drug Classes (1)

Research

Studies (7)

Market Indicators

Research Demand Index: 12.78

Study Types