Compounds > 15,16-dihydro-11-methylcyclopenta(a)phenanthren-17-one
Page last updated: 2024-11-10

15,16-dihydro-11-methylcyclopenta(a)phenanthren-17-one

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

15,16-dihydro-11-methylcyclopenta(a)phenanthren-17-one: structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID3034752
SCHEMBL ID3346375
MeSH IDM0047532

Synonyms (20)

Synonym
ccris 972
15,16-dihydro-11-methyl-17h-cyclopenta(a)phenanthren-17-one
brn 2280058
15,16-dihydro-11-methylcyclopenta(a)phenanthren-17-one
17h-cyclopenta(a)phenanthren-17-one, 15,16-dihydro-11-methyl-
11-methyl-15,16-dihydro-17-oxocyclopenta(a)phenanthrene
11-methyl-15,16-dihydro-17h-cyclopenta(a)phenanthren-17-one
11-methyl-15,16-dihydrocyclopenta[a]phenanthren-17-one
unii-xf4wdu563x
11-ch3-cpp-17-one
11-methyl-15,16-dihydrocyclopenta(a)phenanthren-17-one
892-17-1
xf4wdu563x ,
SCHEMBL3346375
15,16-dihydro-11-methyl-17h-cyclopenta[a]phenanthren-17-one
DTXSID00237571
15,16-dihydro-11-methylcyclopenta[a]phenanthrene-17-one
cyclopenta(a)phenanthrene-11-methyl-15,16-dihydro-17-one
11-methyl-15h-cyclopenta(a)phenanthren-17(16h)-one
dihydro-11-methyl-17h-cyclopenta(a)phenanthren-17-one, 15,16-
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (16)

TimeframeStudies, This Drug (%)All Drugs %
pre-199011 (68.75)18.7374
1990's5 (31.25)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.46

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.46 (24.57)
Research Supply Index2.89 (2.92)
Research Growth Index4.35 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.46)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other17 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
croton oil
[no description available]		1.9610N-acyl-hexosamine
benzo(a)pyrene
Benzo(a)pyrene: A potent mutagen and carcinogen. It is a public health concern because of its possible effects on industrial workers, as an environmental pollutant, an as a component of tobacco smoke.. benzo[a]pyrene : An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.		1.9610ortho- and peri-fused polycyclic arenecarcinogenic agent;
mouse metabolite
2-naphthylamine
2-Naphthylamine: A naphthalene derivative with carcinogenic action.. 2-naphthylamine : A naphthylamine carrying the amino group at position 2.		1.9610naphthylaminecarcinogenic agent
tetradecanoylphorbol acetate
Tetradecanoylphorbol Acetate: A phorbol ester found in CROTON OIL with very effective tumor promoting activity. It stimulates the synthesis of both DNA and RNA.. phorbol ester : Esters of phorbol, originally found in croton oil (from Croton tiglium, of the family Euphorbiaceae). A number of phorbol esters possess activity as tumour promoters and activate the mechanisms associated with cell growth. Some of these are used in experiments as activators of protein kinase C.. phorbol 13-acetate 12-myristate : A phorbol ester that is phorbol in which the hydroxy groups at the cyclopropane ring juction (position 13) and the adjacent carbon (position 12) have been converted into the corresponding acetate and myristate esters. It is a major active constituent of the seed oil of Croton tiglium. It has been used as a tumour promoting agent for skin carcinogenesis in rodents and is associated with increased cell proliferation of malignant cells. However its function is controversial since a decrease in cell proliferation has also been observed in several cancer cell types.		1.9810acetate ester;
diester;
phorbol ester;
tertiary alpha-hydroxy ketone;
tetradecanoate ester		antineoplastic agent;
apoptosis inducer;
carcinogenic agent;
mitogen;
plant metabolite;
protein kinase C agonist;
reactive oxygen species generator
15,16-dihydrocyclopenta(a)phenanthren-17-one
15,16-dihydrocyclopenta(a)phenanthren-17-one: structure		2.3720
guanine
[no description available]		1.96102-aminopurines;
oxopurine;
purine nucleobase		algal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
ConditionIndicatedRelationship StrengthStudiesTrials
Aneuploid
[description not available]		01.9610
Experimental Neoplasms
[description not available]		02.6530
Cancer of Skin
[description not available]		03.2260
Cocarcinogenesis
The combination of two or more different factors in the production of cancer.		02.3620
Skin Neoplasms
Tumors or cancer of the SKIN.		03.2260
Breast Cancer
[description not available]		01.9810
Breast Neoplasms
Tumors or cancer of the human BREAST.		01.9810
Experimental Mammary Neoplasms
[description not available]		01.9510
Papilloma, Squamous Cell
[description not available]		02.3820
Papilloma
A circumscribed benign epithelial tumor projecting from the surrounding surface; more precisely, a benign epithelial neoplasm consisting of villous or arborescent outgrowths of fibrovascular stroma covered by neoplastic cells. (Stedman, 25th ed)		02.3820
Adenoma, Basal Cell
[description not available]		01.9710
Granulocytic Leukemia
[description not available]		01.9710
Cancer of Lung
[description not available]		01.9710
Adenoma
A benign epithelial tumor with a glandular organization.		01.9710
Leukemia, Myeloid
Form of leukemia characterized by an uncontrolled proliferation of the myeloid lineage and their precursors (MYELOID PROGENITOR CELLS) in the bone marrow and other sites.		01.9710
Lung Neoplasms
Tumors or cancer of the LUNG.		01.9710
Mesothelioma
A tumor derived from mesothelial tissue (peritoneum, pleura, pericardium). It appears as broad sheets of cells, with some regions containing spindle-shaped, sarcoma-like cells and other regions showing adenomatous patterns. Pleural mesotheliomas have been linked to exposure to asbestos. (Dorland, 27th ed)		01.9710
Hepatocellular Carcinoma
[description not available]		01.9610
Cancer of Liver
[description not available]		01.9610
Carcinoma, Hepatocellular
A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.		01.9610
Liver Neoplasms
Tumors or cancer of the LIVER.		01.9610