Page last updated: 2024-12-11

14-iodo-15-hydroxyeicosatrienoic acid, omega lactone

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

## 14-Iodo-15-hydroxyeicosatrienoic acid (14-I-15-HETE) omega lactone

This is a complex and somewhat unusual molecule, so let's break it down:

**1. The Basics:**

* **14-I-15-HETE:** This part refers to the main structure of the molecule, **hydroxyeicosatrienoic acid**. HETE signifies a fatty acid with 20 carbons (eicos) and three double bonds (trienoic). The 14-I-15-HETE specifically means:
* **14-I:** The molecule has an iodine atom (I) attached at the 14th carbon.
* **15-HETE:** The molecule has a hydroxyl group (OH) attached at the 15th carbon.
* **Omega Lactone:** This indicates that the molecule forms a cyclic ester (lactone) at the omega end of the fatty acid chain. The omega end refers to the last carbon in the chain.

**2. Importance in Research:**

While 14-I-15-HETE omega lactone is not a well-established molecule with extensive research, its potential importance stems from a few factors:

* **Unique Chemical Structure:** The combination of iodine, hydroxyl, and the lactone structure makes this molecule very specific and could have unique biological properties.
* **Potential Biological Targets:** It's possible that this molecule could bind to specific proteins or receptors in the body. This might lead to interesting biological effects, potentially in areas like inflammation, cell signaling, or even drug development.
* **Analogue of Known Biomolecules:** It resembles known biological molecules like 15-HETE, which is involved in various biological processes. Investigating this molecule could provide insights into how 15-HETE functions and potentially uncover new pathways.

**3. Challenges and Future Research:**

* **Limited Information:** The literature on 14-I-15-HETE omega lactone is scarce. More research is needed to fully understand its properties and biological activity.
* **Synthesis and Analysis:** Synthesizing and analyzing this specific molecule can be challenging due to its complex structure.
* **Target Identification:** Determining which specific proteins or receptors this molecule interacts with will be crucial for understanding its biological functions.

**In summary, 14-I-15-HETE omega lactone is a unique and potentially interesting molecule that requires further investigation. It could offer new insights into biological processes and potentially lead to the development of novel drugs or therapies.**

14-iodo-15-hydroxyeicosatrienoic acid, omega lactone: lactone lactoperoxidase iodination product of arachidonic acid [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID6439489
MeSH IDM0095471

Synonyms (9)

Synonym
oxacyclohexadeca-6,9,12-trien-2-one, 15-iodo-16-pentyl-
il-w
14-iodo-omega-lactone
14-iheaol
il-omega
15-hydroxy-14-iodo-5,8,11-eicosatrienoic acid omega lactone
78000-89-2
14-iodo-15-hydroxyeicosatrienoic acid, omega lactone
(6z,9z,12z)-15-iodo-16-pentyl-1-oxacyclohexadeca-6,9,12-trien-2-one

Research Excerpts

Dosage Studied

ExcerptRelevanceReference
" A dose-response relationship was observed, the minimal effective dose (i."( Studies on the goiter inhibiting action of iodolactones.
Bocanera, LV; Chester, HA; Juvenal, GJ; Krawiec, L; Pisarev, MA; Pregliasco, LB; Sartorio, G, 1994
)
0.29
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (20.00)18.7374
1990's4 (80.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 13.09

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index13.09 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.88 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (13.09)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]