Compounds > 12-(4-azido-2-nitrophenoxy)stearoylglucosamine
Page last updated: 2024-12-08
12-(4-azido-2-nitrophenoxy)stearoylglucosamine
Description
12-(4-azido-2-nitrophenoxy)stearoylglucosamine is a **synthetic glycolipid**. It's a complex molecule composed of several parts:
* **Stearoylglucosamine:** This is a fatty acid (stearic acid) linked to glucosamine, a sugar molecule.
* **4-azido-2-nitrophenoxy:** This is an aromatic ring with a nitro group and an azido group attached.
The significance of this compound lies in its **photoactivatable nature**:
* The azido group is a **photolabile group**. When exposed to UV light, it undergoes a **photochemical reaction**, transforming into a highly reactive species called a **nitrene**.
* This nitrene can then react with nearby molecules, forming a **covalent bond**.
**Research Importance:**
This photoactivatable property makes 12-(4-azido-2-nitrophenoxy)stearoylglucosamine a valuable tool in various research areas:
* **Cell Biology:** It can be used to **label and study specific cellular components**. For example, it can be incorporated into cell membranes and then photoactivated to crosslink proteins or other molecules within the membrane. This helps researchers understand membrane organization, protein interactions, and signaling pathways.
* **Drug Delivery:** It can be employed to **target drugs specifically to cells** by exploiting their cell surface receptors or other markers. The drug can be attached to the molecule, and the azido group can be used to release the drug upon exposure to UV light.
* **Material Science:** The photoactivation property can be used to **modify and functionalize materials**. For example, it can be used to create new polymers with tailored properties or to modify existing materials for improved performance.
**In summary, 12-(4-azido-2-nitrophenoxy)stearoylglucosamine is a synthetic glycolipid with a unique photoactivatable property, making it a valuable tool for research in cell biology, drug delivery, and material science.**
12-(4-azido-2-nitrophenoxy)stearoylglucosamine: used as photoreactive probe for glycolipids; RN given refers to unlabeled cpd [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
| ID Source | ID |
|---|
| PubMed CID | 196448 |
| MeSH ID | M0071598 |
Synonyms (5)
| Synonym |
|---|
| 67576-26-5 |
| d-glucose-1-14c, 2-((12-(4-azido-2-nitrophenoxy)-1-oxooctadecyl)amino)-2-deoxy- |
| 12-(4-azido-2-nitrophenoxy)stearoylglucosamine |
| DTXSID00986936 |
| 2-{[12-(4-azido-2-nitrophenoxy)-1-hydroxyoctadecylidene]amino}-2-deoxyhexose |
Research
Studies (6)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|
| pre-1990 | 6 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Market Indicators
Research Demand Index: 12.50
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| Metric | This Compound (vs All) |
|---|
| Research Demand Index | 12.50 (24.57) | | Research Supply Index | 1.95 (2.92) | | Research Growth Index | 4.45 (4.65) | | Search Engine Demand Index | 0.00 (26.88) | | Search Engine Supply Index | 0.00 (0.95) |
| |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 6 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |