Compounds > 11-oxo-delta(8)-tetrahydrocannabinol
Page last updated: 2024-12-07

11-oxo-delta(8)-tetrahydrocannabinol

Description

**11-oxo-delta(8)-tetrahydrocannabinol (11-oxo-THC)** is a metabolite of delta-9-tetrahydrocannabinol (THC), the primary psychoactive compound in cannabis.

**Importance for Research:**

**1. Understanding THC Metabolism:**
* 11-oxo-THC is a major metabolite of THC in humans. Studying its formation and elimination provides insights into the metabolic pathways of THC and its pharmacokinetics.

**2. Therapeutic Potential:**
* Some research suggests that 11-oxo-THC may have therapeutic potential. It has been found to exhibit anti-inflammatory and analgesic properties, which could be beneficial for treating conditions like chronic pain and inflammation.

**3. Cannabinoid Receptor Interactions:**
* 11-oxo-THC has been shown to interact with cannabinoid receptors, albeit with a lower affinity than THC. Understanding its receptor interactions could shed light on the mechanisms of cannabinoid signaling and the effects of THC on the body.

**4. Drug Testing and Analysis:**
* 11-oxo-THC is detectable in urine and blood samples for longer periods than THC itself. This makes it a valuable marker for detecting cannabis use in drug testing.

**5. Pharmacology and Toxicology:**
* Research on 11-oxo-THC helps to understand its pharmacological effects and potential toxicities. This information is crucial for assessing the safety and efficacy of cannabis use.

**6. Forensic Science:**
* The detection of 11-oxo-THC can assist in forensic investigations, as it can help determine the time of cannabis use and differentiate between recent and past consumption.

**7. Synthetic Cannabinoids:**
* 11-oxo-THC is a structural analogue of synthetic cannabinoids, such as K2 and Spice. Understanding its properties could help in developing treatments for intoxication from these substances.

**Conclusion:**

11-oxo-THC is an important metabolite of THC that has significant implications for research in various fields. Its therapeutic potential, pharmacological properties, and role in drug testing and forensic science make it a crucial area of study.

11-oxo-delta(8)-tetrahydrocannabinol: metabolite of THC [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID124158
MeSH IDM0074180

Synonyms (8)

Synonym
11-oxo-thc
(6ar,10ar)-1-hydroxy-6,6-dimethyl-3-pentyl-6a,7,10,10a-tetrahydrobenzo[c]chromene-9-carbaldehyde
53865-18-2
11-oxo-delta(8)-tetrahydrocannabinol
6h-dibenzo(b,d)pyran-9-carboxaldehyde, 6a,7,10,10a-tetrahydro-1-hydroxy-6,6-dimethyl-3-pentyl-, (6ar-trans)-
Q50318234
1-hydroxy-6,6-dimethyl-3-pentyl-6a,7,10,10a-tetrahydro-6h-dibenzo[b,d]pyran-9-carbaldehyde
DTXSID20968638
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Pathways (1)

PathwayProteinsCompounds
Metabolism of tetrahydrocannabinol (THC)25

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (25.00)18.7374
1990's6 (75.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other10 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
pentobarbital
Pentobarbital: A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA Drug Evaluations Annual, 1994, p236). pentobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and sec-pentyl groups.		1.9610barbituratesGABAA receptor agonist
dronabinol
Dronabinol: A psychoactive compound extracted from the resin of Cannabis sativa (marihuana, hashish). The isomer delta-9-tetrahydrocannabinol (THC) is considered the most active form, producing characteristic mood and perceptual changes associated with this compound.. Delta(9)-tetrahydrocannabinol : A diterpenoid that is 6a,7,8,10a-tetrahydro-6H-benzo[c]chromene substituted at position 1 by a hydroxy group, positions 6, 6 and 9 by methyl groups and at position 3 by a pentyl group. The principal psychoactive constituent of the cannabis plant, it is used for treatment of anorexia associated with AIDS as well as nausea and vomiting associated with cancer chemotherapy.		3.4780benzochromene;
diterpenoid;
phytocannabinoid;
polyketide		cannabinoid receptor agonist;
epitope;
hallucinogen;
metabolite;
non-narcotic analgesic
11-hydroxy-delta(8)-tetrahydrocannabinol
11-hydroxy-delta(8)-tetrahydrocannabinol: metabolite of THC; RN given refers to cpd without isomeric designation		1.9610
9-anthraldehyde
[no description available]		1.9810
11-nor-delta(8)-tetrahydrocannabinol-9-carboxylic acid
[no description available]		1.9710
11-hydroxy-delta(9)-tetrahydrocannabinol
11-hydroxy-delta(9)-tetrahydrocannabinol: metabolite of marijuana; structure; RN given refers to cpd without isomeric designation. 11-hydroxy-Delta(9)-tetrahydrocannabinol : A phytocannabinoid that is Delta(9)-tetrahydrocannabinol in which the methyl group at C-11 has been hydroxylated . Major metabolite of Delta(9)-tetrahydrocannabinol.		1.9810phytocannabinoidhuman xenobiotic metabolite
11-nor-delta(9)-tetrahydrocannabinol-9-carboxylic acid
11-nor-delta(9)-tetrahydrocannabinol-9-carboxylic acid: RN given refers to cpd without isomeric designation; a major acidic metabolite of tetrahydrocannabinol in human urine		1.97101-benzopyran
ConditionIndicatedRelationship StrengthStudiesTrials
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