Page last updated: 2024-12-08

11 alpha-bromoacetoxyprogesterone

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

## 11 alpha-bromoacetoxyprogesterone (11α-BAP)

11α-BAP is a synthetic steroid hormone that is a derivative of progesterone. It's specifically a **brominated** derivative, meaning a bromine atom has been added to the progesterone molecule at the 11α position.

**Importance in research:**

11α-BAP holds significance in research primarily due to its **anti-androgenic activity**, meaning it can block the action of androgens like testosterone. This makes it valuable for studying:

* **Androgen-dependent diseases:** 11α-BAP can be used to model and study diseases like prostate cancer and androgenetic alopecia (male pattern baldness), which are driven by androgen activity.
* **Hormonal regulation:** It can help researchers understand the complex interplay of hormones in the body, particularly the role of androgens in various physiological processes.
* **Development of new drugs:** 11α-BAP can serve as a starting point for designing new drugs that target androgen receptors, potentially leading to therapies for various medical conditions.

**Other key points:**

* **Specificity:** 11α-BAP exhibits high specificity for the androgen receptor, making it a valuable tool for studying this particular receptor and its role in different processes.
* **Potency:** Its anti-androgenic potency is significant, enabling it to effectively block androgen action in experimental settings.

**Limitations:**

* **Toxicity:** While 11α-BAP is a valuable research tool, it can have potential toxicity, limiting its use in humans.
* **Not a therapeutic agent:** It is primarily used in research, not as a medication for treating specific conditions.

**In summary:** 11α-BAP is a powerful research tool that has significantly contributed to our understanding of androgen action and opened new avenues for developing androgen-targeting therapies. Its unique properties make it an invaluable asset for scientific investigations in various fields.

Cross-References

ID SourceID
PubMed CID160258
CHEMBL ID3247090
SCHEMBL ID6998159
MeSH IDM0047346

Synonyms (13)

Synonym
pregn-4-ene-3,20-dione, 11-((bromoacetyl)oxy)-, (11-alpha)-
11alpha-bromoacetoxyprogesterone
(11-alpha)-11-((bromoacetyl)oxy)pregn-4-ene-3,20-dione
cgp 10945
11-alpha-(bromoacetoxy)progesterone
brn 2020016
36049-50-0
[(8s,9s,10r,11r,13s,14s,17s)-17-acetyl-10,13-dimethyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-11-yl] 2-bromoacetate
CHEMBL3247090
SCHEMBL6998159
11 alpha-bromoacetoxyprogesterone
3,20-dioxopregn-4-en-11-yl bromoacetate
DTXSID90957458
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (1)

Assay IDTitleYearJournalArticle
AID1134309Termination of pregnancy in intact rat assessed as fetal resorption administered into uterine lumen on day 7 measured on day 141977Journal of medicinal chemistry, Jun, Volume: 20, Issue:6
Synthesis of medroxyprogesterone bromoacetate for affinity labeling.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19906 (75.00)18.7374
1990's2 (25.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.13

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.13 (24.57)
Research Supply Index2.20 (2.92)
Research Growth Index4.32 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.13)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]