Compounds > 11 alpha-bromoacetoxyprogesterone
Page last updated: 2024-12-08

11 alpha-bromoacetoxyprogesterone

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

## 11 alpha-bromoacetoxyprogesterone (11α-BAP)

11α-BAP is a synthetic steroid hormone that is a derivative of progesterone. It's specifically a **brominated** derivative, meaning a bromine atom has been added to the progesterone molecule at the 11α position.

**Importance in research:**

11α-BAP holds significance in research primarily due to its **anti-androgenic activity**, meaning it can block the action of androgens like testosterone. This makes it valuable for studying:

* **Androgen-dependent diseases:** 11α-BAP can be used to model and study diseases like prostate cancer and androgenetic alopecia (male pattern baldness), which are driven by androgen activity.
* **Hormonal regulation:** It can help researchers understand the complex interplay of hormones in the body, particularly the role of androgens in various physiological processes.
* **Development of new drugs:** 11α-BAP can serve as a starting point for designing new drugs that target androgen receptors, potentially leading to therapies for various medical conditions.

**Other key points:**

* **Specificity:** 11α-BAP exhibits high specificity for the androgen receptor, making it a valuable tool for studying this particular receptor and its role in different processes.
* **Potency:** Its anti-androgenic potency is significant, enabling it to effectively block androgen action in experimental settings.

**Limitations:**

* **Toxicity:** While 11α-BAP is a valuable research tool, it can have potential toxicity, limiting its use in humans.
* **Not a therapeutic agent:** It is primarily used in research, not as a medication for treating specific conditions.

**In summary:** 11α-BAP is a powerful research tool that has significantly contributed to our understanding of androgen action and opened new avenues for developing androgen-targeting therapies. Its unique properties make it an invaluable asset for scientific investigations in various fields.

Cross-References

ID SourceID
PubMed CID160258
CHEMBL ID3247090
SCHEMBL ID6998159
MeSH IDM0047346

Synonyms (13)

Synonym
pregn-4-ene-3,20-dione, 11-((bromoacetyl)oxy)-, (11-alpha)-
11alpha-bromoacetoxyprogesterone
(11-alpha)-11-((bromoacetyl)oxy)pregn-4-ene-3,20-dione
cgp 10945
11-alpha-(bromoacetoxy)progesterone
brn 2020016
36049-50-0
[(8s,9s,10r,11r,13s,14s,17s)-17-acetyl-10,13-dimethyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-11-yl] 2-bromoacetate
CHEMBL3247090
SCHEMBL6998159
11 alpha-bromoacetoxyprogesterone
3,20-dioxopregn-4-en-11-yl bromoacetate
DTXSID90957458
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (1)

Assay IDTitleYearJournalArticle
AID1134309Termination of pregnancy in intact rat assessed as fetal resorption administered into uterine lumen on day 7 measured on day 141977Journal of medicinal chemistry, Jun, Volume: 20, Issue:6
Synthesis of medroxyprogesterone bromoacetate for affinity labeling.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19906 (75.00)18.7374
1990's2 (25.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.13

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.13 (24.57)
Research Supply Index2.20 (2.92)
Research Growth Index4.32 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.13)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
iodine
Iodine: A nonmetallic element of the halogen group that is represented by the atomic symbol I, atomic number 53, and atomic weight of 126.90. It is a nutritionally essential element, especially important in thyroid hormone synthesis. In solution, it has anti-infective properties and is used topically.. diiodine : Molecule comprising two covalently bonded iodine atoms with overall zero charge..		1.9510diatomic iodinenutrient
estrone
Hydroxyestrones: Estrone derivatives substituted with one or more hydroxyl groups in any position. They are important metabolites of estrone and other estrogens.		6.961017-oxo steroid;
3-hydroxy steroid;
phenolic steroid;
phenols		antineoplastic agent;
bone density conservation agent;
estrogen;
human metabolite;
mouse metabolite
androsterone
[no description available]		6.971017-oxo steroid;
3alpha-hydroxy steroid;
androstanoid;
C19-steroid		androgen;
anticonvulsant;
human blood serum metabolite;
human metabolite;
human urinary metabolite;
mouse metabolite;
pheromone
dehydroepiandrosterone
Dehydroepiandrosterone: A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone (DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE) before secretion.. dehydroepiandrosterone : An androstanoid that is androst-5-ene substituted by a beta-hydroxy group at position 3 and an oxo group at position 17. It is a naturally occurring steroid hormone produced by the adrenal glands.		1.961017-oxo steroid;
3beta-hydroxy-Delta(5)-steroid;
androstanoid		androgen;
human metabolite;
mouse metabolite
methionine
Methionine: A sulfur-containing essential L-amino acid that is important in many body functions.. methionine : A sulfur-containing amino acid that is butyric acid bearing an amino substituent at position 2 and a methylthio substituent at position 4.		2.3620aspartate family amino acid;
L-alpha-amino acid;
methionine zwitterion;
methionine;
proteinogenic amino acid		antidote to paracetamol poisoning;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical
histidine
Histidine: An essential amino acid that is required for the production of HISTAMINE.. L-histidine : The L-enantiomer of the amino acid histidine.. histidine : An alpha-amino acid that is propanoic acid bearing an amino substituent at position 2 and a 1H-imidazol-4-yl group at position 3.		2.3720amino acid zwitterion;
histidine;
L-alpha-amino acid;
polar amino acid zwitterion;
proteinogenic amino acid		algal metabolite;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
Saccharomyces cerevisiae metabolite
medroxyprogesterone acetate
[no description available]		1.951020-oxo steroid;
3-oxo-Delta(4) steroid;
acetate ester;
corticosteroid;
steroid ester		adjuvant;
androgen;
antineoplastic agent;
antioxidant;
female contraceptive drug;
inhibitor;
progestin;
synthetic oral contraceptive
bromine
Bromine: A halogen with the atomic symbol Br, atomic number 35, and atomic weight 79.904. It is a volatile reddish-brown liquid that gives off suffocating vapors, is corrosive to the skin, and may cause severe gastroenteritis if ingested.		1.9510diatomic bromine
chlorine
Chlorine: An element with atomic symbol Cl, atomic number 17, and atomic weight 35, and member of the halogen family.		1.9510diatomic chlorine;
gas molecular entity		bleaching agent
phenyl acetate
phenyl acetate: The ester formed between phenol and acetic acid. Don't confuse with phenylacetic acid derivatives listed under PHENYLACETATES.. phenyl acetate : An acetate ester obtained by the formal condensation of phenol with acetic acid.		1.9510benzenes;
phenyl acetates
estrone 3-bromoacetate
estrone 3-bromoacetate: RN given refers to (bromoacetyl-2-(14C))-labeled cpd		6.9610
3-bromoacetoxyandrostan-17-one
3-bromoacetoxyandrostan-17-one: structure given in first source		1.9710
cortisone
[no description available]		1.951011-oxo steroid;
17alpha-hydroxy steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(4) steroid;
C21-steroid;
glucocorticoid;
primary alpha-hydroxy ketone;
tertiary alpha-hydroxy ketone		human metabolite;
mouse metabolite
cysteine
Cysteine: A thiol-containing non-essential amino acid that is oxidized to form CYSTINE.. L-cysteinium : The L-enantiomer of cysteinium.. cysteine : A sulfur-containing amino acid that is propanoic acid with an amino group at position 2 and a sulfanyl group at position 3.		7.3620cysteiniumfundamental metabolite
nad
NAD(1-) : An anionic form of nicotinamide adenine dinucleotide arising from deprotonation of the two OH groups of the diphosphate moiety.		2.3820organophosphate oxoanioncofactor;
human metabolite;
hydrogen acceptor;
Saccharomyces cerevisiae metabolite
ConditionIndicatedRelationship StrengthStudiesTrials
Fetal Resorption
The disintegration and assimilation of the dead FETUS in the UTERUS at any stage after the completion of organogenesis which, in humans, is after the 9th week of GESTATION. It does not include embryo resorption (see EMBRYO LOSS).		01.9510
Pregnancy
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.		02.6530