11,12-dihydroxyeicosatrienoic acid

Description

## 11,12-Dihydroxyeicosatrienoic acid (DiHETrE): A Key Player in Inflammation and Beyond

**11,12-Dihydroxyeicosatrienoic acid (DiHETrE)** is a lipid mediator formed from the omega-3 fatty acid **eicosapentaenoic acid (EPA)**. It's a **hydroxy-eicosatrienoic acid (HETrE)**, meaning it's a derivative of EPA with hydroxyl groups attached to carbons 11 and 12.

**Why is DiHETrE important for research?**

* **Inflammation:** DiHETrE is a potent **anti-inflammatory** agent. It acts by inhibiting the production of pro-inflammatory mediators like TNF-α and IL-1β, while promoting the release of anti-inflammatory cytokines like IL-10.
* **Cardiovascular Health:** Studies suggest DiHETrE might play a role in **reducing cardiovascular risk** by inhibiting platelet aggregation and reducing blood pressure.
* **Neuroprotection:** DiHETrE has shown **neuroprotective effects** in animal models of stroke and Alzheimer's disease.
* **Cancer:** DiHETrE has demonstrated **anticancer properties** in some studies, inhibiting tumor growth and promoting apoptosis.

**DiHETrE's Role in Research:**

* **Understanding Inflammation:** DiHETrE provides a crucial model for investigating the role of EPA-derived mediators in inflammation.
* **Developing New Therapies:** The anti-inflammatory, cardiovascular, and neuroprotective properties of DiHETrE make it a potential target for developing new drugs for a variety of diseases.
* **Unraveling the Complexities of Lipid Signaling:** DiHETrE's involvement in multiple biological processes highlights the complexity of lipid signaling pathways and their impact on human health.

**Current Research:**

Researchers are currently investigating the specific mechanisms by which DiHETrE exerts its effects, as well as its potential therapeutic applications in various diseases.

**Important Note:** DiHETrE is a product of EPA, which is an omega-3 fatty acid found in fatty fish, fish oil supplements, and some plant-based foods. While DiHETrE is a promising research target, it's important to consult with a healthcare professional before making any changes to your diet or supplementation.

(5Z,8Z,14Z)-11,12-dihydroxyicosatrienoic acid : A DHET obtained by formal dihydroxylation across the 11,12-double bond of arachidonic acid. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]