Page last updated: 2024-12-06

10-hydroxycapric acid

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

10-Hydroxycapric acid, also known as **10-Hydroxydecanoic acid**, is a medium-chain fatty acid with a hydroxyl group attached to the 10th carbon atom. It is a naturally occurring compound found in small amounts in various plants and animals.

**Research Importance:**

10-Hydroxycapric acid has gained attention in research due to its potential biological activities, including:

* **Antimicrobial activity:** It exhibits significant antibacterial and antifungal properties. This makes it a potential candidate for developing new antimicrobial agents.
* **Antioxidant activity:** It has been shown to scavenge free radicals and protect cells from oxidative damage. This property may be beneficial for preventing various diseases, including cancer and cardiovascular disease.
* **Anti-inflammatory activity:** It possesses anti-inflammatory properties, potentially contributing to the treatment of inflammatory conditions.
* **Anti-diabetic activity:** Studies have suggested that 10-hydroxycapric acid may improve glucose tolerance and reduce insulin resistance, potentially benefitting individuals with diabetes.
* **Neuroprotective activity:** Preliminary evidence suggests that it might protect neurons from damage caused by neurodegenerative diseases like Alzheimer's and Parkinson's.

**Current Research:**

* **Drug development:** Researchers are investigating the potential of 10-hydroxycapric acid as a therapeutic agent for various diseases, including infections, inflammation, and diabetes.
* **Cosmetics and skincare:** Due to its antimicrobial and antioxidant properties, it is being explored as an ingredient in cosmetic products for its potential benefits to skin health.
* **Food science:** It may be used as a natural preservative in food products.

**Overall, 10-hydroxycapric acid is a promising compound with diverse biological activities. Continued research is crucial to understand its full potential and develop safe and effective applications.**

**Note:** It's essential to remember that research on 10-hydroxycapric acid is still ongoing, and more studies are needed to confirm its efficacy and safety for human use.

10-hydroxycapric acid : A 10-carbon, omega-hydroxy fatty acid, shown to be the preferred hydroxylation product (together with the 9-OH isomer) of capric acid in biosystems, and used as a standard in lipid assays; reported to have cytotoxic effects. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID74300
CHEMBL ID4519263
CHEBI ID17409
SCHEMBL ID126592

Synonyms (46)

Synonym
CHEBI:17409
10-hydroxycapric acid
10-oh-capric acid
10-oh-decanoic acid
nsc15139
nsc-15139
decanoic acid, 10-hydroxy-
C02774
10-hydroxydecanoic acid ,
1679-53-4
10-hydroxydecanoate ,
nsc-159288
nsc159288
27925-00-4
10-hydroxy capric acid
10-hydroxy-decanoic acid
LMFA01050033
10-hydroxydecanoic acid, technical grade
unii-np03xo416b
np03xo416b ,
nsc 15139
einecs 216-848-1
FT-0633763
10-hydroxydecanoic acid [inci]
teenactine
AKOS015856518
S5370
SCHEMBL126592
SY018296
mfcd00010510
W-107905
DTXSID10168428
CHEMBL4519263
CS-D1134
10-hydroxydecanoicacid
DS-3877
10-hydroxydecanoate;decanoic acid, 10-hydroxy-
BCP21629
HY-Y0148
Q18343392
CCG-266486
10-hydroxydecanoic acid (nsc 15139)
BAA67953
Z1255434772
10-hydroxydecanoic acid 98%
EN300-223806
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (2)

ClassDescription
straight-chain saturated fatty acidAny saturated fatty acid lacking a side-chain.
omega-hydroxy-medium-chain fatty acidA omega-hydroxy-fatty acid with a chain length ranging from C6 to C12.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (20)

Assay IDTitleYearJournalArticle
AID1635119Effect on HDAC5 mRNA expression in human THP1 cells at 1 mM after 24 hrs by RT-PCR method2016Journal of natural products, Apr-22, Volume: 79, Issue:4
Royal Jelly Constituents Increase the Expression of Extracellular Superoxide Dismutase through Histone Acetylation in Monocytic THP-1 Cells.
AID1635120Effect on HDAC6 mRNA expression in human THP1 cells at 1 mM after 24 hrs by RT-PCR method2016Journal of natural products, Apr-22, Volume: 79, Issue:4
Royal Jelly Constituents Increase the Expression of Extracellular Superoxide Dismutase through Histone Acetylation in Monocytic THP-1 Cells.
AID1635122Effect on HDAC9 mRNA expression in human THP1 cells at 1 mM after 24 hrs by RT-PCR method2016Journal of natural products, Apr-22, Volume: 79, Issue:4
Royal Jelly Constituents Increase the Expression of Extracellular Superoxide Dismutase through Histone Acetylation in Monocytic THP-1 Cells.
AID1635105Upregulation of HDAC1 inhibition/ERK signalling activation-mediated extracellular SOD mRNA expression in human THP1 cells at 1 mM after 24 hrs by RT-PCR method2016Journal of natural products, Apr-22, Volume: 79, Issue:4
Royal Jelly Constituents Increase the Expression of Extracellular Superoxide Dismutase through Histone Acetylation in Monocytic THP-1 Cells.
AID1635104Upregulation of HDAC1 inhibition/ERK signalling activation-mediated extracellular SOD protein expression in human THP1 cells at 1 mM after 24 hrs by ELISA2016Journal of natural products, Apr-22, Volume: 79, Issue:4
Royal Jelly Constituents Increase the Expression of Extracellular Superoxide Dismutase through Histone Acetylation in Monocytic THP-1 Cells.
AID1635139Inhibition of recombinant HDAC1 catalytic domain (unknown origin) using HDAC substrate at 1 mM preincubated for 1 hr followed by substrate addition measured after 30 mins by fluorescence assay relative to control2016Journal of natural products, Apr-22, Volume: 79, Issue:4
Royal Jelly Constituents Increase the Expression of Extracellular Superoxide Dismutase through Histone Acetylation in Monocytic THP-1 Cells.
AID1635112Upregulation of HDAC1 inhibition-mediated histone H4 acetylation-induced extracellular SOD expression in human THP1 cells at 1 mM after 12 hrs by chromatin immunoprecipitation method2016Journal of natural products, Apr-22, Volume: 79, Issue:4
Royal Jelly Constituents Increase the Expression of Extracellular Superoxide Dismutase through Histone Acetylation in Monocytic THP-1 Cells.
AID1635117Effect on HDAC8 mRNA expression in human THP1 cells at 1 mM after 24 hrs by RT-PCR method2016Journal of natural products, Apr-22, Volume: 79, Issue:4
Royal Jelly Constituents Increase the Expression of Extracellular Superoxide Dismutase through Histone Acetylation in Monocytic THP-1 Cells.
AID1635116Effect on HDAC3 mRNA expression in human THP1 cells at 1 mM after 24 hrs by RT-PCR method2016Journal of natural products, Apr-22, Volume: 79, Issue:4
Royal Jelly Constituents Increase the Expression of Extracellular Superoxide Dismutase through Histone Acetylation in Monocytic THP-1 Cells.
AID1635124Inhibition of HDAC activity in human THP1 cells at 1 mM preincubated for 1 hr followed by substrate addition measured after 2 hrs by fluorescence assay relative to control2016Journal of natural products, Apr-22, Volume: 79, Issue:4
Royal Jelly Constituents Increase the Expression of Extracellular Superoxide Dismutase through Histone Acetylation in Monocytic THP-1 Cells.
AID1635121Effect on HDAC7 mRNA expression in human THP1 cells at 1 mM after 24 hrs by RT-PCR method2016Journal of natural products, Apr-22, Volume: 79, Issue:4
Royal Jelly Constituents Increase the Expression of Extracellular Superoxide Dismutase through Histone Acetylation in Monocytic THP-1 Cells.
AID1635102Effect on Cu/Zn SOD mRNA expression in human THP1 cells at 1 mM after 24 hrs by RT-PCR method2016Journal of natural products, Apr-22, Volume: 79, Issue:4
Royal Jelly Constituents Increase the Expression of Extracellular Superoxide Dismutase through Histone Acetylation in Monocytic THP-1 Cells.
AID1635109Inhibition of HDAC1 in human THP1 cells assessed as increase in histone H3 acetylation level at 1 mM after 12 hrs by Western blot analysis relative to control2016Journal of natural products, Apr-22, Volume: 79, Issue:4
Royal Jelly Constituents Increase the Expression of Extracellular Superoxide Dismutase through Histone Acetylation in Monocytic THP-1 Cells.
AID1635115Effect on HDAC2 mRNA expression in human THP1 cells at 1 mM after 24 hrs by RT-PCR method2016Journal of natural products, Apr-22, Volume: 79, Issue:4
Royal Jelly Constituents Increase the Expression of Extracellular Superoxide Dismutase through Histone Acetylation in Monocytic THP-1 Cells.
AID1635118Effect on HDAC4 mRNA expression in human THP1 cells at 1 mM after 24 hrs by RT-PCR method2016Journal of natural products, Apr-22, Volume: 79, Issue:4
Royal Jelly Constituents Increase the Expression of Extracellular Superoxide Dismutase through Histone Acetylation in Monocytic THP-1 Cells.
AID1635108Inhibition of HDAC1 in human THP1 cells assessed as increase in histone H4 acetylation level at 1 mM after 12 hrs by Western blot analysis relative to control2016Journal of natural products, Apr-22, Volume: 79, Issue:4
Royal Jelly Constituents Increase the Expression of Extracellular Superoxide Dismutase through Histone Acetylation in Monocytic THP-1 Cells.
AID1635114Effect on HDAC1 mRNA expression in human THP1 cells at 1 mM after 24 hrs by RT-PCR method2016Journal of natural products, Apr-22, Volume: 79, Issue:4
Royal Jelly Constituents Increase the Expression of Extracellular Superoxide Dismutase through Histone Acetylation in Monocytic THP-1 Cells.
AID1635103Upregulation of Mn SOD mRNA expression in human THP1 cells at 1 mM after 24 hrs by RT-PCR method2016Journal of natural products, Apr-22, Volume: 79, Issue:4
Royal Jelly Constituents Increase the Expression of Extracellular Superoxide Dismutase through Histone Acetylation in Monocytic THP-1 Cells.
AID1635113Upregulation of HDAC1 inhibition-mediated histone H3 acetylation-induced extracellular SOD expression in human THP1 cells at 1 mM after 12 hrs by chromatin immunoprecipitation method2016Journal of natural products, Apr-22, Volume: 79, Issue:4
Royal Jelly Constituents Increase the Expression of Extracellular Superoxide Dismutase through Histone Acetylation in Monocytic THP-1 Cells.
AID1635123Effect on HDAC10 mRNA expression in human THP1 cells at 1 mM after 24 hrs by RT-PCR method2016Journal of natural products, Apr-22, Volume: 79, Issue:4
Royal Jelly Constituents Increase the Expression of Extracellular Superoxide Dismutase through Histone Acetylation in Monocytic THP-1 Cells.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (10)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's4 (40.00)24.3611
2020's6 (60.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.16

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.16 (24.57)
Research Supply Index2.48 (2.92)
Research Growth Index4.64 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.16)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials1 (10.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other9 (90.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]