Compounds > 10-hydroxyasimicin
Page last updated: 2024-11-12

10-hydroxyasimicin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

10-hydroxyasimicin: a bis-tetrahydrofuran acetogenin with 4 hydroxyl groups; from Asimina triloba; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

FloraRankFlora DefinitionFamilyFamily Definition
AsiminagenusA plant genus of the family ANNONACEAE. It has edible fruit and seeds which contain asitrocin, asitrilobins, and other tetrahydrofuran acetogenins.[MeSH]AnnonaceaeThe custard-apple plant family of the order Magnoliales, subclass Magnoliidae, class Magnoliopsida. Some members provide large pulpy fruits and commercial timber. Leaves and wood are often fragrant. Leaves are simple, with smooth margins, and alternately arranged in two rows along the stems.[MeSH]

Cross-References

ID SourceID
PubMed CID10532159
CHEMBL ID443639
SCHEMBL ID11981831
MeSH IDM0270483

Synonyms (4)

Synonym
CHEMBL443639
10-hydroxyasimicin
SCHEMBL11981831
(2s)-2-methyl-4-[(2r,8r,13r)-2,8,13-trihydroxy-13-[(2r,5r)-5-[(2r,5r)-5-[(1r)-1-hydroxyundecyl]oxolan-2-yl]oxolan-2-yl]tridecyl]-2h-furan-5-one
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (14)

Assay IDTitleYearJournalArticle
AID355177Cytotoxicity against human HT29 cells after 7 days by MTT assay1996Journal of natural products, Nov, Volume: 59, Issue:11
Three new adjacent bis-tetrahydrofuran acetogenins with four hydroxyl groups from Asimina triloba.
AID355180Cytotoxicity against human MIAPaCa2 cells after 7 days by MTT assay1996Journal of natural products, Nov, Volume: 59, Issue:11
Three new adjacent bis-tetrahydrofuran acetogenins with four hydroxyl groups from Asimina triloba.
AID355174Toxicity to Artemia salina1996Journal of natural products, Nov, Volume: 59, Issue:11
Three new adjacent bis-tetrahydrofuran acetogenins with four hydroxyl groups from Asimina triloba.
AID379125Cytotoxicity against human A-498 cells1999Journal of natural products, Mar, Volume: 62, Issue:3
Annonaceous acetogenins: recent progress.
AID379112Cytotoxicity against human MIA PaCa2 cells1999Journal of natural products, Mar, Volume: 62, Issue:3
Annonaceous acetogenins: recent progress.
AID355178Cytotoxicity against human A498 cells after 7 days by MTT assay1996Journal of natural products, Nov, Volume: 59, Issue:11
Three new adjacent bis-tetrahydrofuran acetogenins with four hydroxyl groups from Asimina triloba.
AID355179Cytotoxicity against human PC3 cells after 7 days by MTT assay1996Journal of natural products, Nov, Volume: 59, Issue:11
Three new adjacent bis-tetrahydrofuran acetogenins with four hydroxyl groups from Asimina triloba.
AID379124Cytotoxicity against human HT-29 cells1999Journal of natural products, Mar, Volume: 62, Issue:3
Annonaceous acetogenins: recent progress.
AID379111Cytotoxicity against human PC-3 cells1999Journal of natural products, Mar, Volume: 62, Issue:3
Annonaceous acetogenins: recent progress.
AID379122Cytotoxicity against human A549 cells1999Journal of natural products, Mar, Volume: 62, Issue:3
Annonaceous acetogenins: recent progress.
AID379121Toxicity in brine shrimp1999Journal of natural products, Mar, Volume: 62, Issue:3
Annonaceous acetogenins: recent progress.
AID355176Cytotoxicity against human MCF7 cells after 7 days by MTT assay1996Journal of natural products, Nov, Volume: 59, Issue:11
Three new adjacent bis-tetrahydrofuran acetogenins with four hydroxyl groups from Asimina triloba.
AID379123Cytotoxicity against human MCF7 cells1999Journal of natural products, Mar, Volume: 62, Issue:3
Annonaceous acetogenins: recent progress.
AID355175Cytotoxicity against human A549 cells after 7 days by MTT assay1996Journal of natural products, Nov, Volume: 59, Issue:11
Three new adjacent bis-tetrahydrofuran acetogenins with four hydroxyl groups from Asimina triloba.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's3 (60.00)18.2507
2000's2 (40.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.50

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.50 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.29 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.50)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (20.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other4 (80.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
bendiocarb
bendiocarb: FICAM 80W contains 80% of the above chemical cpd as the active ingredient		3.110benzodioxoles;
carbamate ester		agrochemical;
carbamate insecticide;
EC 3.1.1.7 (acetylcholinesterase) inhibitor
chlorpyrifos
Chlorpyrifos: An organothiophosphate cholinesterase inhibitor that is used as an insecticide and as an acaricide.. chlorpyrifos : An organic thiophosphate that is O,O-diethyl hydrogen phosphorothioate in which the hydrogen of the hydroxy group has been replaced by a 3,5,6-trichloropyridin-2-yl group.		3.110chloropyridine;
organic thiophosphate		acaricide;
agrochemical;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor;
environmental contaminant;
insecticide;
xenobiotic
cypermethrin
cypermethrin : A carboxylic ester resulting from the formal condensation between 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid and the alcoholic hydroxy group of hydroxy(3-phenoxyphenyl)acetonitrile.. zeta-cypermethrin : A diastereoisomeric mixture comprising the isomeric pair (1R)-cis-(alphaS)- and (1S)-trans-(alphaR)-cypermethrin together with the isomeric pair (1S)-cis-(alphaS)- and (1S)-trans-(alphaS)-cypermethrin where the ratio between the isomeric pairs lies in the range 45:55 to 55:45.		3.110aromatic ether;
cyclopropanecarboxylate ester;
nitrile;
organochlorine compound		agrochemical;
molluscicide;
pyrethroid ester acaricide;
pyrethroid ester insecticide
propoxur
Propoxur: A carbamate insecticide.. propoxur : A carbamate ester that is phenyl methylcarbamate substituted at position 2 by a propan-2-yloxy group.		3.110aromatic ether;
carbamate ester		acaricide;
agrochemical;
carbamate insecticide;
EC 3.1.1.7 (acetylcholinesterase) inhibitor
4-butyrolactone
4-Butyrolactone: One of the FURANS with a carbonyl thereby forming a cyclic lactone. It is an endogenous compound made from gamma-aminobutyrate and is the precursor of gamma-hydroxybutyrate. It is also used as a pharmacological agent and solvent.. tetrahydrofuranone : Any oxolane having an oxo- substituent at any position on the tetrahydrofuran ring.. gamma-butyrolactone : A butan-4-olide that is tetrahydrofuran substituted by an oxo group at position 2.		210butan-4-olidemetabolite;
neurotoxin
alkenes
[no description available]		2.0410
desacetyluvaricin
desacetyluvaricin: isolated from Uvaria accuminata; structure given in first source		1.9910
4-hydroxy-25-desoxyneorollinicin
4-hydroxy-25-desoxyneorollinicin: isol from Rollina papilionella; structure given in first source		210
hydramethylnon
hydramethylnon: used as fire ant insecticide in southern USA; poorly absorbed by mammals & more than 95% is excreted unchanged in the feces. hydramethylnon : A member of the class of hydrazones that is used as an insecticide for control of ants and cockroaches.		3.110hydramethylnon
allylsilane
allylsilane: structure in first source		2.0410
pyranicin
pyranicin: structure in first source		3.110
pyragonicin
pyragonicin: structure in first source		3.110
trilobacin
trilobacin: from the bark of Asimina triloba; structure given in first source. trilobacin : A polyketide isolated from the bark of Asimina triloba. It has been shown to exhibit cytotoxicity in the NCI human tumor cell line screen.		1.9910butenolide;
polyketide;
triol		antineoplastic agent;
plant metabolite
isomurisolenin
isomurisolenin: an acetogenin from seeds of Annona reticulata;		210
ConditionIndicatedRelationship StrengthStudiesTrials