10(9)-hydroxystearic acid profile

It seems like you're asking about **10(S)-hydroxystearic acid**. It's a fatty acid with a hydroxyl group (-OH) at the 10th carbon position. This molecule is interesting due to its biological relevance and potential applications in research.

Here's what makes 10(S)-hydroxystearic acid important:

**1. Biological Relevance:**

* **Found in Nature:** It's found in various organisms, including plants and animals. For example, it's a significant component of certain fats and oils.
* **Potential Role in Cellular Processes:** Studies suggest it might play a role in cell signaling and membrane function. This is because the hydroxyl group can interact with other molecules and influence the structure and behavior of cell membranes.

**2. Research Applications:**

* **Biomaterials and Drug Delivery:** Researchers are exploring its potential as a building block for biocompatible materials and drug delivery systems. Its unique structure and properties, like its ability to form micelles, make it attractive for these applications.
* **Food Science:** 10(S)-hydroxystearic acid's presence in certain foods is being investigated in relation to its potential health benefits or its role in food stability.
* **Synthesis and Chemical Studies:** It's used as a starting material for synthesizing other molecules with potential biological activity.
* **Cosmetic Industry:** It's showing potential use in cosmetic formulations due to its moisturizing and skin-conditioning properties.

**Important Note:** Research into 10(S)-hydroxystearic acid is ongoing. While promising, its exact biological roles and potential applications are still under investigation.

If you have more specific questions about its properties, research findings, or applications in a particular field, please let me know.

10(9)-hydroxystearic acid: structure; RN given refers to parent cpd; see also records for 9-hydroxystearic acid & 10-hydroxystearic acid [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

9-hydroxyoctadecanoic acid : A hydroxyoctadecanoic acid that is octadecanoic acid (stearic acid) which has been substituted by a hydroxy group at position 9. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

ID Source	ID
PubMed CID	9570127
CHEMBL ID	1093742
CHEBI ID	136638
SCHEMBL ID	465907
MeSH ID	M0051644

Synonym
9-hydroxyoctadecanoic acid
3384-24-5
CHEBI:136638
AKOS000277649
9-hydroxystearic acid
CHEMBL1093742
octadecanoic acid, 9-hydroxy-
dl-9-hydroxy stearic acid
9-hydroxy-octadecanoic acid
LMFA02000127
10(9)-hydroxystearic acid
25498-28-6
9(or 10)-hydroxyoctadecanoic acid
SCHEMBL465907
AKOS025399398
9-hydroxy stearic acid
18:0(9-oh)
FT-0774903
DTXSID60948393
HY-N11692
CS-0716321
PD150705
F73266

Class	Description
hydroxyoctadecanoic acid	A hydroxy fatty acid that is ocatadecanoic acid (stearic acid) in which the aliphatic chain has been substituted by one or more hydroxy groups.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Assay ID	Title	Year	Journal	Article
AID464598	Inhibition of CRM1 interaction with HIV1 HA-tagged Rev in HeLa cells assessed as inhibition of Rev nuclear export by indirect fluorescent antibody technique	2010	Bioorganic & medicinal chemistry letters, Mar-15, Volume: 20, Issue:6	Unprecedented NES non-antagonistic inhibitor for nuclear export of Rev from Sida cordifolia.
AID1831923	Growth inhibition of human A549 cells at 50 microM measured after 72 hrs by MTT assay	2021	Journal of medicinal chemistry, 05-13, Volume: 64, Issue:9	Saturated Oxo Fatty Acids (SOFAs): A Previously Unrecognized Class of Endogenous Bioactive Lipids Exhibiting a Cell Growth Inhibitory Activity.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	2 (9.09)	18.7374
1990's	3 (13.64)	18.2507
2000's	7 (31.82)	29.6817
2010's	8 (36.36)	24.3611
2020's	2 (9.09)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	22 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
carnitine [no description available]	2.25	1	amino-acid betaine	human metabolite; mouse metabolite
palmitic acid Palmitic Acid: A common saturated fatty acid found in fats and waxes including olive oil, palm oil, and body lipids.. hexadecanoic acid : A straight-chain, sixteen-carbon, saturated long-chain fatty acid.	2.89	3	long-chain fatty acid; straight-chain saturated fatty acid	algal metabolite; Daphnia magna metabolite; EC 1.1.1.189 (prostaglandin-E2 9-reductase) inhibitor; plant metabolite
1-anilino-8-naphthalenesulfonate 1-anilino-8-naphthalenesulfonate: RN given refers to parent cpd. 8-anilinonaphthalene-1-sulfonic acid : A naphthalenesulfonic acid that is naphthalene-1-sulfonic acid substituted by a phenylamino group at position 8.	2.15	1	aminonaphthalene; naphthalenesulfonic acid	fluorescent probe
erythrosine Fluoresceins: A family of spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one derivatives. These are used as dyes, as indicators for various metals, and as fluorescent labels in immunoassays.	2.02	1
hydroxyurea [no description available]	1.98	1	one-carbon compound; ureas	antimetabolite; antimitotic; antineoplastic agent; DNA synthesis inhibitor; EC 1.17.4.1 (ribonucleoside-diphosphate reductase) inhibitor; genotoxin; immunomodulator; radical scavenger; teratogenic agent
nocodazole [no description available]	1.98	1	aromatic ketone; benzimidazoles; carbamate ester; thiophenes	antimitotic; antineoplastic agent; microtubule-destabilising agent; tubulin modulator
stearic acid octadecanoic acid : A C18 straight-chain saturated fatty acid component of many animal and vegetable lipids. As well as in the diet, it is used in hardening soaps, softening plastics and in making cosmetics, candles and plastics.	2.31	1	long-chain fatty acid; saturated fatty acid; straight-chain saturated fatty acid	algal metabolite; Daphnia magna metabolite; human metabolite; plant metabolite
durapatite Durapatite: The mineral component of bones and teeth; it has been used therapeutically as a prosthetic aid and in the prevention and treatment of osteoporosis.. hydroxylapatite : A phosphate mineral with the formula Ca5(PO4)3(OH).	2.13	1
methylformamide N-methylformamide : A member of the class of formamides having a N-methyl substituent.	2.03	1	formamides
5-aminofluorescein 5-aminofluorescein: used to determine progesterone in human serum or plasma. 5-aminofluorescein : A primary amino compound that is fluorescein carrying an amino substituent at C-5. Building block/intermediate for the synthesis of the fluorescent dye flourescein; also used to produce N-(fluorescein-5-yl)maleamic acid.	2.02	1	primary amino compound
6-keto stearic acid [no description available]	2.31	1	long-chain fatty acid
palmitoleic acid hexadecenoate : A long-chain unsaturated fatty acid anion that is the conjugate base of hexadecenoic acid, obtained by deprotonation of the carboxy group; major species at pH 7.3.	2.25	1	hexadec-9-enoic acid	algal metabolite; Daphnia galeata metabolite; EC 3.1.1.1 (carboxylesterase) inhibitor; Escherichia coli metabolite; human blood serum metabolite
bromochloroacetic acid Keratins: A class of fibrous proteins or scleroproteins that represents the principal constituent of EPIDERMIS; HAIR; NAILS; horny tissues, and the organic matrix of tooth ENAMEL. Two major conformational groups have been characterized, alpha-keratin, whose peptide backbone forms a coiled-coil alpha helical structure consisting of TYPE I KERATIN and a TYPE II KERATIN, and beta-keratin, whose backbone forms a zigzag or pleated sheet structure. alpha-Keratins have been classified into at least 20 subtypes. In addition multiple isoforms of subtypes have been found which may be due to GENE DUPLICATION.. bromochloroacetic acid : A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is replaced by bromine while a second is replaced by chlorine. A low-melting (27.5-31.5degreeC), hygroscopic crystalline solid, it can be formed during the disinfection (by chlorination) of water that contains bromide ions and organic matter, so can occur in drinking water as a byproduct of the disinfection process.	2.21	1	2-bromocarboxylic acid; monocarboxylic acid; organochlorine compound
trans-10,cis-12-conjugated linoleic acid (10E,12Z)-octadecadienoic acid : An octadeca-10,12-dienoic acid having (10E,12Z)-configuration.	2.05	1	octadeca-10,12-dienoic acid
9-hydroxy-10,12-octadecadienoic acid 9-hydroxy-10,12-octadecadienoic acid: RN given refers to unspecified stereoisomer. 9-HODE : A HODE that consists of (10E,12Z)-octadecadienoic acid with the hydroxy substituent located at position 9.	2.05	1	HODE; octadecadienoic acid	human metabolite; metabolite; mouse metabolite; plant metabolite
10-hydroxystearic acid 10-hydroxystearic acid: structure given in first source; see also record for 10(9)-hydroxystearic acid. 10-hydroxyoctadecanoic acid : A hydroxy fatty acid that is octadecanoic acid carrying a hydroxy group at position 10.	3.09	5	hydroxy fatty acid; long-chain fatty acid	bacterial xenobiotic metabolite
epidermal growth factor Epidermal Growth Factor: A 6-kDa polypeptide growth factor initially discovered in mouse submaxillary glands. Human epidermal growth factor was originally isolated from urine based on its ability to inhibit gastric secretion and called urogastrone. Epidermal growth factor exerts a wide variety of biological effects including the promotion of proliferation and differentiation of mesenchymal and EPITHELIAL CELLS. It is synthesized as a transmembrane protein which can be cleaved to release a soluble active form.	2.03	1
cyclin d1 Cyclin D1: Protein encoded by the bcl-1 gene which plays a critical role in regulating the cell cycle. Overexpression of cyclin D1 is the result of bcl-1 rearrangement, a t(11;14) translocation, and is implicated in various neoplasms.	2.45	2

Condition	Relationship Strength	Studies
Cardiovascular Diseases Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.	2.25	1
Adenocarcinoma, Basal Cell [description not available]	2.72	3
Cancer of Colon [description not available]	3.41	7
Adenocarcinoma A malignant epithelial tumor with a glandular organization.	2.72	3
Colonic Neoplasms Tumors or cancer of the COLON.	3.41	7
Osteogenic Sarcoma [description not available]	2.03	1
Osteosarcoma A sarcoma originating in bone-forming cells, affecting the ends of long bones. It is the most common and most malignant of sarcomas of the bones, and occurs chiefly among 10- to 25-year-old youths. (From Stedman, 25th ed)	2.03	1
Carcinoma, Lewis Lung A carcinoma discovered by Dr. Margaret R. Lewis of the Wistar Institute in 1951. This tumor originated spontaneously as a carcinoma of the lung of a C57BL mouse. The tumor does not appear to be grossly hemorrhagic and the majority of the tumor tissue is a semifirm homogeneous mass. (From Cancer Chemother Rep 2 1972 Nov;(3)1:325) It is also called 3LL and LLC and is used as a transplantable malignancy.	1.98	1
Cancer of Lung [description not available]	2.38	2
Lung Neoplasms Tumors or cancer of the LUNG.	2.38	2
Carcinoma, Anaplastic [description not available]	2.01	1
Carcinoma A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm and not a synonym for cancer.	2.01	1
Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)	2.01	1
Chronic Illness [description not available]	1.96	1
Chronic Disease Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2).	1.96	1
Diarrhea An increased liquidity or decreased consistency of FECES, such as running stool. Fecal consistency is related to the ratio of water-holding capacity of insoluble solids to total water, rather than the amount of water present. Diarrhea is not hyperdefecation or increased fecal weight.	1.96	1
Cystic Fibrosis of Pancreas [description not available]	1.97	1
Cystic Fibrosis An autosomal recessive genetic disease of the EXOCRINE GLANDS. It is caused by mutations in the gene encoding the CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR expressed in several organs including the LUNG, the PANCREAS, the BILIARY SYSTEM, and the SWEAT GLANDS. Cystic fibrosis is characterized by epithelial secretory dysfunction associated with ductal obstruction resulting in AIRWAY OBSTRUCTION; chronic RESPIRATORY INFECTIONS; PANCREATIC INSUFFICIENCY; maldigestion; salt depletion; and HEAT PROSTRATION.	1.97	1

10(9)-hydroxystearic acid

Description

Cross-References

Synonyms (23)

Drug Classes (1)

Bioassays (2)

Research

Studies (22)

Market Indicators

Research Demand Index: 11.72

Study Types