Page last updated: 2024-12-10

1-thiophen-2-ylsulfonyl-4-piperidinecarboxylic acid 1,3-benzothiazol-2-ylmethyl ester

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

1-thiophen-2-ylsulfonyl-4-piperidinecarboxylic acid 1,3-benzothiazol-2-ylmethyl ester is a complex chemical compound with a long and descriptive name. It's a bit difficult to find concrete information about this specific molecule because its full name isn't commonly used in scientific literature.

**To understand its importance, we need to break down its components and look for clues about its potential uses.**

* **1-thiophen-2-ylsulfonyl-4-piperidinecarboxylic acid:** This part likely refers to a substituted piperidine ring. Piperidine rings are common in many pharmaceuticals and are often associated with various biological activities. The thiophen-2-ylsulfonyl group likely modifies the piperidine ring, potentially influencing its pharmacological properties.
* **1,3-benzothiazol-2-ylmethyl ester:** This part refers to a derivative of benzothiazole, a heterocyclic ring system with significant medicinal relevance. It's commonly found in compounds with diverse biological activities, including anti-inflammatory, antifungal, and antibacterial properties.

**Possible Importance for Research:**

Based on its structure, this compound could be:

* **A potential drug candidate:** The presence of piperidine and benzothiazole rings suggests that this compound could exhibit interesting biological activity and be a potential lead for the development of new drugs.
* **A tool for chemical biology research:** It might be used to study the interactions between piperidine derivatives and biological targets, potentially providing valuable insights into drug design or the function of certain proteins.
* **A building block for synthesizing more complex molecules:** The compound might be used as an intermediate in the synthesis of other molecules with more specific properties.

**To determine its precise importance, more information is needed, such as:**

* **Its specific biological activity:** Does it have any known effects on cells, tissues, or organisms?
* **Its synthesis and characterization:** How is it prepared, and what are its physical and chemical properties?
* **Its research context:** What research areas is it being investigated in, and what are the specific goals of the research?

In conclusion, 1-thiophen-2-ylsulfonyl-4-piperidinecarboxylic acid 1,3-benzothiazol-2-ylmethyl ester is likely a complex molecule with potential importance for drug discovery, chemical biology research, or synthetic chemistry. Further investigation is needed to understand its specific properties and applications.

Cross-References

ID SourceID
PubMed CID2999008
CHEMBL ID1504361
CHEBI ID114992

Synonyms (14)

Synonym
MLS000056089
smr000067195
OPREA1_085577
CHEBI:114992
MLS002633587
1,3-benzothiazol-2-ylmethyl 1-thiophen-2-ylsulfonylpiperidine-4-carboxylate
HMS2339L09
CHEMBL1504361
SR-01000054812-1
sr-01000054812
1-thiophen-2-ylsulfonyl-4-piperidinecarboxylic acid 1,3-benzothiazol-2-ylmethyl ester
Q27196836
Z18992995
AKOS033653475
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
benzothiazoles
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (11)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
LuciferasePhotinus pyralis (common eastern firefly)Potency22.54100.007215.758889.3584AID411; AID588342
ATAD5 protein, partialHomo sapiens (human)Potency14.78830.004110.890331.5287AID504466; AID504467
P53Homo sapiens (human)Potency50.11870.07319.685831.6228AID504706
chromobox protein homolog 1Homo sapiens (human)Potency89.12510.006026.168889.1251AID540317
nuclear factor erythroid 2-related factor 2 isoform 2Homo sapiens (human)Potency11.22020.00419.984825.9290AID504444
importin subunit beta-1 isoform 1Homo sapiens (human)Potency15.84895.804836.130665.1308AID540263
pyruvate kinase PKM isoform aHomo sapiens (human)Potency8.91250.04017.459031.6228AID1631; AID1634
DNA polymerase betaHomo sapiens (human)Potency19.95260.022421.010289.1251AID485314
snurportin-1Homo sapiens (human)Potency15.84895.804836.130665.1308AID540263
Inositol monophosphatase 1Rattus norvegicus (Norway rat)Potency1.25891.000010.475628.1838AID901
ATP-dependent phosphofructokinaseTrypanosoma brucei brucei TREU927Potency5.35820.060110.745337.9330AID485367
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (13)

Assay IDTitleYearJournalArticle
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID504812Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID1745845Primary qHTS for Inhibitors of ATXN expression
AID651635Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID504810Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (20.00)29.6817
2010's3 (60.00)24.3611
2020's1 (20.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.56

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.56 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.36 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.56)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]