1-sulfooxymethylpyrene

Description

1-sulfooxymethylpyrene (1-SMP) is a **highly reactive electrophilic metabolite** of pyrene, a polycyclic aromatic hydrocarbon (PAH).

Here's why it's important in research:

* **DNA Adduct Formation:** 1-SMP is known to form DNA adducts, meaning it binds to DNA molecules. This can lead to mutations in DNA, which are a major contributing factor to cancer development.

* **Carcinogenesis:** Studies have shown that 1-SMP is a potent carcinogen, meaning it can cause cancer. Its ability to form DNA adducts contributes to its carcinogenic activity.

* **Toxicology and Environmental Health:** 1-SMP is an important indicator of exposure to pyrene, a common environmental pollutant found in coal tar, diesel exhaust, and cigarette smoke. Studying its formation and effects on cells can help us understand the health risks associated with pyrene exposure.

* **Biomarker Research:** 1-SMP can be used as a biomarker of exposure to pyrene and potentially other PAHs. Measuring its levels in biological samples like urine or blood can provide insights into individual exposure to these carcinogenic compounds.

* **Mechanism of Action:** Investigating the molecular mechanisms by which 1-SMP interacts with DNA and causes cellular damage can lead to the development of preventive and therapeutic strategies for PAH-related diseases.

**Overall, 1-SMP plays a crucial role in understanding the toxic effects of pyrene and other PAHs on human health. Research on this compound is essential for developing strategies to prevent and treat PAH-related cancers and other health problems.**

1-sulfooxymethylpyrene: metabolite of 1-methylpyrene; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]