Page last updated: 2024-12-11

1-stearoyl-2-linoleoylphosphatidylcholine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

## 1-Stearoyl-2-linoleoylphosphatidylcholine (18:0/18:2 PC)

**What is it?**

1-Stearoyl-2-linoleoylphosphatidylcholine (18:0/18:2 PC) is a specific type of **phospholipid**, a molecule that forms the structural basis of cell membranes. It is a **glycerophospholipid** containing:

* **Glycerol:** a three-carbon alcohol backbone.
* **Stearic acid:** a saturated fatty acid with 18 carbon atoms (18:0).
* **Linoleic acid:** an unsaturated fatty acid with 18 carbon atoms and two double bonds (18:2).
* **Phosphate:** a negatively charged group.
* **Choline:** a nitrogen-containing compound.

**Why is it important for research?**

18:0/18:2 PC is an important research tool due to several reasons:

* **Model of biological membranes:** Being a common phospholipid found in cell membranes, it serves as a model system for studying membrane structure and function. Researchers can use this molecule to investigate how different factors affect membrane fluidity, protein interactions, and other properties.
* **Lipid signaling:** 18:0/18:2 PC is involved in various cellular signaling pathways, including those related to inflammation, cell growth, and apoptosis. Understanding its role in these pathways can lead to the development of new drugs targeting specific signaling processes.
* **Drug delivery:** As a major component of liposomes, 18:0/18:2 PC can be used to encapsulate drugs and deliver them to specific target sites in the body. This approach is gaining increasing attention for developing more targeted and efficient drug therapies.
* **Food science:** 18:0/18:2 PC plays a crucial role in the texture and stability of foods. Its properties influence the physical characteristics of products like margarine, ice cream, and mayonnaise.

**Specific examples of research applications:**

* **Investigating the effects of cholesterol on membrane fluidity:** By varying the amount of 18:0/18:2 PC and cholesterol in model membranes, researchers can study how cholesterol affects membrane fluidity and its implications for membrane protein function.
* **Developing new drug delivery systems:** 18:0/18:2 PC is incorporated into liposomes to create drug carriers that can target specific cell types or tissues.
* **Understanding the role of phospholipids in neurodegenerative diseases:** 18:0/18:2 PC is implicated in the progression of diseases like Alzheimer's and Parkinson's, making it a crucial target for research.

**In summary, 1-stearoyl-2-linoleoylphosphatidylcholine is a versatile research tool that enables scientists to study membrane structure, signaling pathways, drug delivery, and various aspects of food science.**

1-octadecanoyl-2-[(9Z,12Z)-octadecadienoyl]-sn-glycero-3-phosphocholine : A phosphatidylcholine 36:2 in which the acyl groups positions 1 and 2 are specified as octadecanoyl and (9Z,12Z)-octadecadienoyl respectively. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID6441487
CHEBI ID84822
SCHEMBL ID233018
MeSH IDM0168328

Synonyms (47)

Synonym
slpc
1-octadecanoyl-2-(9z,12z-octadecadienoyl)-sn-glycero-3-phosphocholine
1-stearoyl-2-linoleoyl-sn-glycero-3-phosphatidylcholine
1-stearoyl-2-linoleoyl-sn-glycero-3-phosphocholine
pc(18:0/18:2(9z,12z))
1-stearoyl-2-linoleoylphosphatidylcholine
phosphatidylcholine(18:0/18:2w6)
LMGP01010768
18:0-18:2-pc
1-18:0-2-18:2-phosphatidylcholine
phosphatidylcholine (1-18:0-2-18:2)
[(2r)-2-[(9z,12z)-octadeca-9,12-dienoyl]oxy-3-octadecanoyloxypropyl] 2-(trimethylazaniumyl)ethyl phosphate
phosphatidylcholine(18:0/18:2)
1-stearoyl-2-linoleoyl-gpc (18:0/18:2)
(2r)-2-[(9z,12z)-octadeca-9,12-dienoyloxy]-3-(octadecanoyloxy)propyl 2-(trimethylammonio)ethyl phosphate
phosphatidylcholine(36:2)
1-octadecanoyl-2-[(9z,12z)-octadecadienoyl]-sn-glycero-3-phosphocholine
gpcho(18:0/18:2w6)
gpc(18:0/18:2)
(2r)-2-[(9z,12z)-octadeca-9,12-dienoyloxy]-3-(octadecanoyloxy)propyl 2-(trimethylazaniumyl)ethyl phosphate
gpcho(18:0/18:2n6)
pc(18:0/18:2n6)
phosphatidylcholine(18:0/18:2n6)
CHEBI:84822
1-stearoyl-2-linoleoyl-gpc
1-octadecanoyl-2-(9z,12z)-octadecadienoyl-sn-glycero-3-phosphocholine
gpcho(18:0/18:2)
pc(18:0/18:2w6)
27098-24-4
1-stearoyl-(2-linoleoyl)-sn-glycero-3-phosphocholine
slptc
3,5,9-trioxa-4-phosphaheptacosan-1-aminium, 4-hydroxy-n,n,n-trimethyl-10-oxo-7-((1-oxo-9,12-octadecadienyl)oxy)-, inner salt, 4-oxide, (r-(z,z))-
gpcho(36:2)
SCHEMBL233018
liver pc, l-alpha-phosphatidylcholine (liver, bovine), powder
18:0-18:2 pc, 1-stearoyl-2-linoleoyl-sn-glycero-3-phosphocholine, chloroform
18:0-18:2 pc, 1-stearoyl-2-linoleoyl-sn-glycero-3-phosphocholine, powder
3,5,9-trioxa-4-phosphaheptacosan-1-aminium, 4-hydroxy-n,n,n-trimethyl-10-oxo-7-[[(9z,12z)-1-oxo-9,12-octadecadien-1-yl]oxy]-, inner salt, 4-oxide, (7r)-
HY-126359
1-steraoyl-2-linoleoyl-sn-glycero-3-phosphorylcholine
Q27105102
trimethyl(2-{[2-[octadeca-9.12-dienoyloxy]-3-(octadecanoyloxy)propyl phosphonato]oxy}ethyl)azanium
CS-0102946
PD166325
3,5,9-trioxa-4-phosphaheptacosan-1-aminium,4-hydroxy-n,n,n-trimethyl-10-oxo-7-[[(9z,12z)-1-oxo-9,12-octadecadien-1-yl]oxy]-,innersalt,4-oxide,(7r)-
DTXSID001230503
AKOS040732231
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

RoleDescription
mouse metaboliteAny mammalian metabolite produced during a metabolic reaction in a mouse (Mus musculus).
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (1)

ClassDescription
phosphatidylcholine 36:2A 1,2-diacyl-sn-glycero-3-phosphocholine in which the acyl groups at C-1 and C-2 contain 36 carbons in total and 2 double bonds.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Pathways (3)

PathwayProteinsCompounds
Phosphatidylcholine Biosynthesis PC(18:0/18:2(9Z,12Z))620
Phosphatidylethanolamine Biosynthesis PE(18:0/18:2(9Z,12Z))516
Phosphatidylcholine/Phosphatidylethanolamine Biosynthesis PC(18:0/18:2(9Z,12Z)) | PE(18:0/18:2(9Z,12Z))617

Research

Studies (10)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (10.00)18.7374
1990's3 (30.00)18.2507
2000's4 (40.00)29.6817
2010's2 (20.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.39

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.39 (24.57)
Research Supply Index2.40 (2.92)
Research Growth Index4.78 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.39)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other10 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]