Page last updated: 2024-12-08

1-phenylpropene

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

## 1-Phenylpropene: Structure, Properties, and Research Significance

**1-Phenylpropene** is an organic compound with the molecular formula C9H10. It is an aromatic hydrocarbon with a phenyl group (C6H5) attached to a propene (C3H6) chain.

**Key Properties:**

* **Appearance:** Colorless liquid
* **Odor:** Aromatic
* **Boiling Point:** 155°C (311°F)
* **Density:** 0.90 g/cm³
* **Solubility:** Insoluble in water, soluble in organic solvents

**Importance in Research:**

1-Phenylpropene is an important research compound for several reasons:

* **Versatile Building Block:** It serves as a versatile starting material for the synthesis of a wide range of organic compounds, including:
* **Pharmaceuticals:** Many pharmaceuticals contain phenylpropene units, making it a valuable precursor for drug development.
* **Polymers:** It can be used as a monomer for the production of polymers with specific properties.
* **Fine Chemicals:** It serves as an intermediate for the synthesis of various fine chemicals, such as fragrances and flavors.
* **Study of Chemical Reactions:** 1-Phenylpropene's reactivity and stability make it a suitable model compound for studying various chemical reactions, including:
* **Electrophilic Aromatic Substitution:** The phenyl ring can undergo electrophilic attack, leading to the formation of various substituted derivatives.
* **Alkylation Reactions:** The double bond in the propene chain can undergo alkylation reactions, expanding the compound's structural diversity.
* **Catalytic Reactions:** 1-Phenylpropene can be used to explore the efficiency and selectivity of various catalysts.
* **Materials Science:** Its unique properties, such as its aromatic nature and unsaturated structure, have led to its exploration for applications in:
* **Polymer Science:** 1-Phenylpropene-based polymers can exhibit enhanced mechanical properties, thermal stability, and optical properties.
* **Organic Electronics:** It can be incorporated into organic electronic devices, like solar cells and transistors, due to its ability to absorb and transport electrons.

**Safety Considerations:**

1-Phenylpropene is a flammable liquid and should be handled with care. It may also be irritating to the skin, eyes, and respiratory system.

**Conclusion:**

1-Phenylpropene is a valuable research compound due to its versatility as a building block, its suitability for studying chemical reactions, and its potential for various applications in materials science. It continues to be a subject of ongoing research, leading to new discoveries and advancements in different fields.

1-phenylpropene: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID252325
CHEMBL ID506013
MeSH IDM0492642

Synonyms (84)

Synonym
9367gub59o ,
3-05-00-01185 (beilstein handbook reference)
unii-9367gub59o
AKOS015840399
benzene, 1-propenyl-, (e)-
benzene-trans-propenyl
.beta.-methylstyrol
isoallylbenzene
nsc65591
1-propene, 1-phenyl-
1-propenylbenzene
nsc-65591
propenylbenzene
.beta.-methylstyrene
1-phenyl-1-propene
637-50-3
.omega.-methylstyrene
benzene, 1-propenyl-
1-phenylpropene
nsc 65591
beta-methylstyrol
einecs 211-287-9
benzene, propenyl-, (e)-
beta-methylstyrene
styrene, beta-methyl-, (e)-
(e)-1-propenylbenzene
(e)-1-phenylpropene
(e)-beta-methylstyrene
hsdb 6504
einecs 212-848-0
brn 1679279
brn 1361672
benzene, propenyl- (van)
nsc 73958
trans-beta-methylstyrene
trans-1-propenylbenzene
wln: 2u1r
propenylbenzene-trans
styrene, (e)-
trans-.beta.-methylstyrene
nsc-73958
trans-propenylbenzene
nsc73958
trans-1-phenylpropene
trans-1-phenyl-1-propene
1-phenyl-1-propene, trans-
873-66-5
(1e)-prop-1-en-1-ylbenzene
benzene, (1e)-1-propenyl-
inchi=1/c9h10/c1-2-6-9-7-4-3-5-8-9/h2-8h,1h3/b6-2
trans-beta-methylstyrene, 99%
[(e)-prop-1-enyl]benzene
M1175
CHEMBL506013
trans-phenylpropene
[(e)-prop-1-enyl]-benzene
4-05-00-01359 (beilstein handbook reference)
unii-a5s9n1785o
trans-propenyl benzene
beta-methylstyrene, trans-
a5s9n1785o ,
methylstyrene, trans-.beta.-
.beta.-methylstyrene, trans-
styrene, .beta.-methyl-, (e)-
AKOS025311179
(e)-prop-1-en-1-ylbenzene
beta-trans-methylstyrene
a-methylstyrol
ss-methylstyrene
DTXSID2060919
(e)-1-phenyl-1-propene
beta-methylstyrene (racemic)
?-methylstyrene (stabilized with tbc)
trans-|a-methylstyrene
F0001-2173
prop-1-en-1-ylbenzene
CS-0069845
Q2020228
CS-15941
H10852
DTXSID101026543
trans- beta -methylstyrene
10.14272/QROGIFZRVHSFLM-QHHAFSJGSA-N.1
doi:10.14272/qrogifzrvhsflm-qhhafsjgsa-n.1
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (3)

Assay IDTitleYearJournalArticle
AID337837Antifungal activity against Pityrosporum ovale ATCC 14521 after 3 days by broth dilution method1993Journal of natural products, Feb, Volume: 56, Issue:2
Combination effects of antifungal nagilactones against Candida albicans and two other fungi with phenylpropanoids.
AID337835Antifungal activity against Saccharomyces cerevisiae ATCC 7754 after 2 days by broth dilution method1993Journal of natural products, Feb, Volume: 56, Issue:2
Combination effects of antifungal nagilactones against Candida albicans and two other fungi with phenylpropanoids.
AID337836Antifungal activity against Candida albicans ATCC 18804 after 2 days by broth dilution method1993Journal of natural products, Feb, Volume: 56, Issue:2
Combination effects of antifungal nagilactones against Candida albicans and two other fungi with phenylpropanoids.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (12)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (8.33)18.2507
2000's4 (33.33)29.6817
2010's6 (50.00)24.3611
2020's1 (8.33)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 41.40

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index41.40 (24.57)
Research Supply Index2.56 (2.92)
Research Growth Index5.07 (4.65)
Search Engine Demand Index54.53 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (41.40)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies2 (16.67%)4.05%
Observational0 (0.00%)0.25%
Other10 (83.33%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]