1-palmitoyl-2-glutaroyl-sn-glycero-3-phosphorylcholine

Description

**1-palmitoyl-2-glutaroyl-sn-glycero-3-phosphorylcholine (PGPC)** is a synthetic phospholipid analog. It is a modified version of phosphatidylcholine (PC), a major component of cell membranes.

**Structure:**

* **Palmitoyl (16:0):** A saturated fatty acid chain with 16 carbon atoms.
* **Glutaroyl (5:0):** A saturated fatty acid chain with 5 carbon atoms.
* **Glycerol:** A three-carbon alcohol.
* **Phosphorylcholine:** A phosphate group linked to choline.

**Importance for Research:**

**1. Cell Membrane Research:**

* PGPC can be used as a tool to study the properties and functions of cell membranes.
* It can be incorporated into artificial membranes (liposomes) to create model systems for studying membrane transport, protein interactions, and other processes.

**2. Drug Delivery Systems:**

* PGPC has been investigated as a potential carrier for drug delivery.
* Its unique chemical structure and ability to interact with cell membranes make it suitable for encapsulating and delivering drugs.

**3. Neurological Research:**

* PGPC has shown potential benefits in the treatment of neurological disorders, such as Alzheimer's disease and Parkinson's disease.
* It has been reported to protect neurons from damage and improve cognitive function.

**4. Inflammation and Immunology:**

* PGPC has anti-inflammatory properties.
* It has been shown to inhibit the production of inflammatory mediators and reduce inflammation in animal models.

**5. Anti-cancer Activity:**

* Some studies suggest that PGPC may have anti-cancer activity.
* It has been shown to inhibit the growth of certain cancer cells.

**6. Other Applications:**

* PGPC has also been investigated for its potential use in cosmetics, food additives, and other applications.

**Conclusion:**

PGPC is a versatile phospholipid analog that has numerous applications in research. Its unique structure and biological properties make it a valuable tool for studying cell membranes, developing drug delivery systems, and exploring new therapeutic strategies for various diseases.

2-O-glutaroyl-1-O-palmitoyl-sn-glycero-3-phosphocholine : A 1,2-diacyl-sn-glycero-3-phosphocholine having palmitoyl and glutaroyl groups at positions 1 and 2 respectively. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]