Compounds > 1-oleoyl-2-docosahexaenoyl phosphatidylcholine
Page last updated: 2024-12-11
1-oleoyl-2-docosahexaenoyl phosphatidylcholine
Description
## 1-Oleoyl-2-docosahexaenoyl phosphatidylcholine (18:1/22:6 PC)
**What it is:**
1-Oleoyl-2-docosahexaenoyl phosphatidylcholine (18:1/22:6 PC) is a specific type of phospholipid, a major component of cell membranes. It's composed of:
* **Phosphatidylcholine (PC):** A common phospholipid containing choline.
* **Oleic acid (18:1):** An unsaturated fatty acid with 18 carbon atoms and one double bond.
* **Docosahexaenoic acid (DHA, 22:6):** A highly unsaturated omega-3 fatty acid with 22 carbon atoms and six double bonds.
This specific molecule is characterized by having oleic acid at the sn-1 position and docosahexaenoic acid at the sn-2 position of the glycerol backbone.
**Importance in research:**
18:1/22:6 PC plays a crucial role in various research areas, including:
* **Brain function:** DHA is a major component of brain cell membranes and is vital for neuronal development, signaling, and cognitive function. Studies using 18:1/22:6 PC help understand how DHA influences brain health and diseases like Alzheimer's and Parkinson's.
* **Cardiovascular health:** 18:1/22:6 PC is implicated in reducing inflammation and improving cardiovascular function. Research using this molecule investigates its potential benefits in treating cardiovascular diseases.
* **Cell signaling:** Phospholipids like 18:1/22:6 PC are essential for cell signaling pathways. Studying its role in these pathways helps understand how cells communicate and respond to stimuli.
* **Membrane fluidity and permeability:** The unique fatty acid composition of 18:1/22:6 PC influences membrane fluidity and permeability. Research investigates its effect on membrane properties and how these affect cell function.
* **Dietary supplements and health benefits:** DHA, a key component of 18:1/22:6 PC, is commonly found in fish oil supplements. Research using 18:1/22:6 PC investigates the efficacy and bioavailability of DHA supplementation.
**Overall, 1-oleoyl-2-docosahexaenoyl phosphatidylcholine is a crucial molecule in various research areas related to cell biology, health, and nutrition. Understanding its function and properties provides valuable insights into the mechanisms underlying various biological processes.**
**Note:** 18:1/22:6 PC is just one example of a specific phospholipid. Research often focuses on other phospholipid species containing different fatty acids and head groups to understand their unique roles in various biological processes.
1-oleoyl-2-docosahexaenoyl phosphatidylcholine: increases paradoxical sleep in rats; structure given in first source; RN given refers to (Z)-isomer; RN for cpd without isomeric designation not available 12/93 [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
| ID Source | ID |
|---|
| PubMed CID | 6438829 |
| MeSH ID | M0224068 |
Synonyms (7)
| Synonym |
|---|
| 1-oleoyl-2-docosahexaenoyl phosphatidylcholine |
| [(2r)-2-[(4e,7z,10e,13e,16e,19e)-docosa-4,7,10,13,16,19-hexaenoyl]oxy-3-[(e)-octadec-9-enoyl]oxypropyl] 2-(trimethylazaniumyl)ethyl phosphate |
| 1-oleoyl-2-docosahexaenoylglycero-3-phosphorylcholine |
| 99296-82-9 |
| 1-odhpc |
| 3,5,8-trioxa-4-phosphatriaconta-12,15,18,21,24,27-hexaen-1-aminium, 4-hydroxy-n,n,n-trimethyl-9-oxo-7-(((1-oxo-9-octadecenyl)oxy)methyl)-, hydroxide, inner salt, 4-oxide, (r-(all-z))- |
| 1-oleoyl-2-dha-pc |
Research
Studies (5)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Market Indicators
Research Demand Index: 12.66
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| Metric | This Compound (vs All) |
|---|
| Research Demand Index | 12.66 (24.57) | | Research Supply Index | 1.79 (2.92) | | Research Growth Index | 4.45 (4.65) | | Search Engine Demand Index | 0.00 (26.88) | | Search Engine Supply Index | 0.00 (0.95) |
| |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 5 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |