Page last updated: 2024-12-07

1-nitrosopyrene

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

## 1-Nitrosopyrene: A Carcinogen of Research Interest

1-Nitrosopyrene is a **highly potent and mutagenic compound** that belongs to the family of **nitro-polycyclic aromatic hydrocarbons (nitro-PAHs)**.

Here's why it's important for research:

**1. Environmental Significance:**

* **Ubiquitous Pollutant:** It's found in **diesel exhaust, coal tar, and cigarette smoke**, making it a common environmental pollutant.
* **Bioaccumulation:** 1-Nitrosopyrene can accumulate in living organisms, posing a potential threat to human health.

**2. Health Risks:**

* **Carcinogen:** It's been classified as a **probable human carcinogen** by the International Agency for Research on Cancer (IARC).
* **Mutagenic:** It causes mutations in DNA, which can lead to cancer development.
* **Respiratory Issues:** Exposure to 1-Nitrosopyrene can cause respiratory problems, such as lung irritation and inflammation.

**3. Research Focus:**

* **Cancer Prevention:** Research on 1-Nitrosopyrene focuses on understanding its carcinogenic mechanisms and developing strategies for cancer prevention.
* **Biomarker Development:** Researchers are exploring the use of 1-Nitrosopyrene levels as biomarkers for exposure to diesel exhaust and other sources of pollution.
* **Environmental Remediation:** Studies investigate methods to remove or neutralize 1-Nitrosopyrene from contaminated environments.

**4. Specific Research Areas:**

* **Metabolism and Toxicity:** Research aims to understand how 1-Nitrosopyrene is metabolized in the body and its toxic effects on various organs.
* **DNA Adducts:** Studying the formation of DNA adducts, the covalent binding of 1-Nitrosopyrene to DNA, is crucial for understanding its carcinogenic potential.
* **Environmental Fate:** Research focuses on understanding the fate of 1-Nitrosopyrene in the environment, including its persistence, degradation, and transport pathways.

**Overall, 1-Nitrosopyrene is a significant research target due to its potential health risks and widespread environmental presence. Further research is crucial for developing strategies to mitigate its harmful effects and protect human health.**

1-nitrosopyrene: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID104777
SCHEMBL ID3341373
MeSH IDM0130407

Synonyms (9)

Synonym
ccris 2586
1-nitrosopyrene
pyrene, 1-nitroso-
86674-51-3
unii-5xc7ze327a
5xc7ze327a ,
SCHEMBL3341373
nitrosopyrene, 1-
DTXSID101007006
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (30)

TimeframeStudies, This Drug (%)All Drugs %
pre-199016 (53.33)18.7374
1990's11 (36.67)18.2507
2000's2 (6.67)29.6817
2010's1 (3.33)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 10.76

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index10.76 (24.57)
Research Supply Index3.53 (2.92)
Research Growth Index4.29 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (10.76)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other33 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]