1,n(2)-ethenodeoxyguanosine profile

The term 1,n(2)-ethenodeoxyguanosine likely refers to **1,N2-ethenodeoxyguanosine**, a DNA adduct formed by the reaction of **etheno** (vinyl) groups with deoxyguanosine (dG).

Here's a breakdown:

* **1,N2-ethenodeoxyguanosine:** This is the specific name of the adduct, indicating the position where the etheno group is attached to deoxyguanosine. The 1 refers to the position on the deoxyribose sugar, and N2 refers to the position on the guanine base.
* **Etheno group (vinyl group):** This is a functional group with the formula CH=CH2. It can be introduced into DNA through various mechanisms, including exposure to environmental toxins like **vinyl chloride**.
* **Deoxyguanosine (dG):** This is one of the four DNA nucleobases, commonly referred to as G in DNA sequences.

**Why is 1,N2-ethenodeoxyguanosine important for research?**

1. **Carcinogenesis:** 1,N2-ethenodeoxyguanosine is a significant mutagen, meaning it can cause changes in DNA sequence. This can lead to cancer development. Its presence in DNA is associated with an increased risk of various cancers, including liver, lung, and bladder cancer.
2. **Biomarker of exposure:** The presence of 1,N2-ethenodeoxyguanosine in DNA can serve as a biomarker for exposure to certain environmental toxins, including vinyl chloride and acrolein. This helps researchers assess the health risks associated with these chemicals.
3. **Understanding DNA damage and repair:** Studying the formation and repair of 1,N2-ethenodeoxyguanosine helps scientists understand the mechanisms of DNA damage and repair pathways. This knowledge can be crucial for developing new treatments for cancer and other diseases associated with DNA damage.
4. **DNA mutation analysis:** Researchers utilize 1,N2-ethenodeoxyguanosine as a model system to study the impact of DNA adducts on DNA replication, transcription, and other cellular processes.

**In summary,** 1,N2-ethenodeoxyguanosine is a significant DNA adduct with implications for cancer research, environmental health, and understanding DNA repair mechanisms. Its study provides valuable insights into the mechanisms of mutagenesis and DNA damage, contributing to the development of new diagnostic and therapeutic approaches.

ID Source	ID
PubMed CID	130591
MeSH ID	M0154042

Synonym
1,n(2)-edguo
3-[(2s,4s,5r)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-4h-imidazo[1,2-a]purin-9-one
9h-imidazo(1,2-a)purin-9-one, 3-(2-deoxy-beta-d-erythro-pentofuranosyl)-3,4-dihydro-
108929-11-9
1,n(2)-ethenodeoxyguanosine
3-(2-deoxypentofuranosyl)-3,4-dihydro-9h-imidazo[1,2-a]purin-9-one
DTXSID30910926

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	1 (6.67)	18.7374
1990's	3 (20.00)	18.2507
2000's	10 (66.67)	29.6817
2010's	1 (6.67)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	17 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
chloroacetaldehyde [no description available]	2.4	2	organochlorine compound
acetaldehyde Acetaldehyde: A colorless, flammable liquid used in the manufacture of acetic acid, perfumes, and flavors. It is also an intermediate in the metabolism of alcohol. It has a general narcotic action and also causes irritation of mucous membranes. Large doses may cause death from respiratory paralysis.. acetaldehyde : The aldehyde formed from acetic acid by reduction of the carboxy group. It is the most abundant carcinogen in tobacco smoke.. aldehyde : A compound RC(=O)H, in which a carbonyl group is bonded to one hydrogen atom and to one R group.. acetyl group : A group, formally derived from acetic acid by dehydroxylation, which is fundamental to the biochemistry of all forms of life. When bound to coenzyme A, it is central to the metabolism of carbohydrates and fats.	2.4	2	aldehyde	carcinogenic agent; EC 3.5.1.4 (amidase) inhibitor; electron acceptor; Escherichia coli metabolite; human metabolite; mouse metabolite; mutagen; oxidising agent; Saccharomyces cerevisiae metabolite; teratogenic agent
cytosine [no description available]	2.04	1	aminopyrimidine; pyrimidine nucleobase; pyrimidone	Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
acrolein [no description available]	2.39	2	enal	herbicide; human xenobiotic metabolite; toxin
1,n(2)-propanodeoxyguanosine 1,N(2)-propanodeoxyguanosine: structure & RN given in first source	1.98	1	carbohydrate derivative; nucleobase-containing molecular entity
cyclic 1,n(2)-propanodeoxyguanosine cyclic 1,N(2)-propanodeoxyguanosine: structure given in first source; RN refers to (6R-trans)-isomer	2.02	1
2-butenal crotonaldehyde : An enal consisting of propene having a formyl group at the 1-position.	1.98	1	enal
4,5-epoxy-2-decenal 4,5-epoxy-2-decenal: structure given in first source	2.01	1	enal
arachidonic acid 5-hydroperoxide arachidonic acid 5-hydroperoxide: 5-HPETE is used inconsistently in literature as syn for cpds with various tetraene locants; RN given refers to (6,8,11,14)-isomer; RN in CA Vol 91 Form Index for (E,Z,Z,Z)-isomer: 70968-82-0; RN for (5,8,11,13)-isomer: 71133-12-5; in Merck, arachidonic acid is the (5,8,11,14)-isomer. 5-HPETE : A HPETE that consists of (6E,8Z,11Z,14Z)-icosatetraenoic acid in which the hydroperoxy group is located at position 5.	2.02	1	HPETE	human xenobiotic metabolite
4-hydroxy-2-nonenal 4-hydroxy-2-nonenal: cytotoxic product from peroxidation of liver microsomal lipids; RN given refers to cpd without isomeric designation. 4-hydroxynon-2-enal : An enal consisting of non-2-ene having an oxo group at the 1-position and a hydroxy group at the 4-position.. 4-hydroxynonenal : A monounsaturated fatty aldehyde that is nonanal that has undergone dehydrogenation to introduce a double bond at any position in the aliphatic chain and in which a hydrogen at position 4 has been replaced by a hydroxy group.	2.39	2	4-hydroxynon-2-enal; 4-hydroxynonenal
2,4-decadienal (2E,4E)-deca-2,4-dienal : A polyunsaturated fatty aldehyde that is decanal which has undergone formal dehydrogenation to introduce trans- double bonds at the 2-3 and 4-5 positions. A product of lipid peroxidation in cell membranes and a component of cooking oil fumes.	2	1	polyunsaturated fatty aldehyde	apoptosis inducer; nematicide
phosphorus Phosphorus: A non-metal element that has the atomic symbol P, atomic number 15, and atomic weight 31. It is an essential element that takes part in a broad variety of biochemical reactions.	2.05	1	monoatomic phosphorus; nonmetal atom; pnictogen	macronutrient
4-oxo-2-nonenal 4-oxo-2-nonenal: reacts with 2'-deoxyguanosine; a product of lipid peroxidation; structure in first source. (E)-4-oxonon-2-enal : The enal that is (E)-non-2-enal substituted with an oxo group at C-4.	2.02	1	enal; enone	human metabolite
oligonucleotides [no description available]	2.42	2
piperidines Piperidines: A family of hexahydropyridines.	1.99	1
9,12-dioxo-10-dodecenoic acid 9,12-dioxo-10-dodecenoic acid: structure in first source	2.02	1
deoxyguanosine [no description available]	4.08	15	purine 2'-deoxyribonucleoside; purines 2'-deoxy-D-ribonucleoside	Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
phosphorus radioisotopes Phosphorus Radioisotopes: Unstable isotopes of phosphorus that decay or disintegrate emitting radiation. P atoms with atomic weights 28-34 except 31 are radioactive phosphorus isotopes.	1.98	1

Condition	Indicated	Relationship Strength	Studies	Trials
Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)	0	2.01	1	0

1,n(2)-ethenodeoxyguanosine

Cross-References

Synonyms (7)

Research

Studies (15)

Market Indicators

Research Demand Index: 12.10

Study Types