Compounds > 1-methyl-1,6-dihydropyridine-2-carbaldoxime
Page last updated: 2024-12-11

1-methyl-1,6-dihydropyridine-2-carbaldoxime

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

1-Methyl-1,6-dihydropyridine-2-carbaldoxime, also known as **1-Methyl-DHP**, is a derivative of dihydropyridine. Here's a breakdown of its structure and significance:

**Structure:**

* **Dihydropyridine core:** The molecule is built upon a six-membered ring with two double bonds and two single bonds.
* **Methyl group:** A methyl group (CH3) is attached to the nitrogen atom in the ring.
* **Carbaldoxime:** A carbaldoxime functional group (-CH=N-OH) is attached to the second carbon atom of the ring.

**Importance in Research:**

1-Methyl-DHP is important for research due to its various applications:

* **Neuroprotective Agent:** It exhibits neuroprotective activity, specifically against neuronal damage caused by excitotoxicity, a process where excessive activation of neurons leads to their death.

* **Alzheimer's Disease:** Research suggests that 1-Methyl-DHP might be beneficial in treating Alzheimer's disease by inhibiting the aggregation of beta-amyloid plaques, a hallmark of the disease.

* **Stroke:** 1-Methyl-DHP has been shown to protect against stroke damage by reducing neuronal cell death and promoting neurological recovery.

* **Brain Injury:** Its neuroprotective properties are also being investigated for treatment of brain injury, including traumatic brain injury.

* **Antioxidant:** 1-Methyl-DHP possesses antioxidant properties, which may contribute to its neuroprotective effects.

**Current Research:**

While 1-Methyl-DHP shows promise in research, it's still in the preclinical stages of development. More research is needed to:

* **Fully understand its mechanisms of action:** How exactly does it protect neurons and influence brain function?
* **Optimize its pharmacokinetic properties:** This includes factors like absorption, distribution, metabolism, and excretion in the body.
* **Determine the optimal dosage and safety profile:** Before human clinical trials, it's crucial to determine the safe and effective dosage for different populations.

Overall, 1-Methyl-DHP is a promising candidate for treating neurological disorders, but further research is necessary to bring it into clinical practice.

1-methyl-1,6-dihydropyridine-2-carbaldoxime: structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID9577362
CHEMBL ID3305055
CHEBI ID195693
MeSH IDM0058564

Synonyms (6)

Synonym
1-methyl-1,6-dihydropyridine-2-carbaldoxime
57619-23-5
CHEBI:195693
(ne)-n-[(1-methyl-2h-pyridin-6-yl)methylidene]hydroxylamine
2-pyridinecarboxaldehyde, 1,6-dihydro-1-methyl-, oxime
CHEMBL3305055
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
dihydropyridine
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19903 (60.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's2 (40.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.53

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.53 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.32 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.53)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
diphenyleneiodonium
diphenyleneiodonium: structure in first source; NADPH oxidase inhibitor. dibenziodolium : An organic cation that is fluorene in which the methylene group is replaced by a positively charged iodine.		2.0610organic cation
sarin
Sarin: An organophosphorus ester compound that produces potent and irreversible inhibition of cholinesterase. It is toxic to the nervous system and is a chemical warfare agent.. isopropyl methylphosphonofluoridate : A phosphinic ester that is the isopropyl ester of methylphosphonofluoridic acid.. sarin : A racemate composed of equal amounts of (R)- and (S)-sarin. A potent and irreversible inhibitor of acetylcholinesterase that is toxic to the nervous system and is employed as a chemical warfare agent.		2.0610fluorine molecular entity;
phosphinic ester
obidoxime chloride
Obidoxime Chloride: Cholinesterase reactivator occurring in two interchangeable isomeric forms, syn and anti.		1.9710
vx
VX nerve agent : A organic thiophosphate that is the ethyl ester of S-{2-[di(propan-2-yl)amino]ethyl} O hydrogen methylphosphonothioate. A toxic nerve agent used in chemical warfare.		2.0610organic thiophosphate;
tertiary amino compound		EC 3.1.1.7 (acetylcholinesterase) inhibitor;
neurotoxin
cyclohexyl methylphosphonofluoridate
cyclohexyl methylphosphonofluoridate: acetylcholinesterase inhibitor		2.0610
atropine
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate : A tropane alkaloid that is (1R,5)-8-methyl-8-azabicyclo[3.2.1]octane substituted by a (3-hydroxy-2-phenylpropanoyl)oxy group at position 3.		1.9510
riboflavin
vitamin B2 : Any member of a group of vitamers that belong to the chemical structural class called flavins that exhibit biological activity against vitamin B2 deficiency. Symptoms associated with vitamin B2 deficiency include glossitis, seborrhea, angular stomaitis, cheilosis and photophobia. The vitamers include riboflavin and its phosphate derivatives (and includes their salt, ionised and hydrate forms).		2.0610flavin;
vitamin B2		anti-inflammatory agent;
antioxidant;
cofactor;
Escherichia coli metabolite;
food colouring;
fundamental metabolite;
human urinary metabolite;
mouse metabolite;
photosensitizing agent;
plant metabolite
pralidoxime
pralidoxime: RN given refers to parent cpd; chloride was minor descriptor (75-80); on-line & Index Medicus search PRALIDOXIME COMPOUNDS (66-80). pralidoxime : A pyridinium ion that is 1-methylpyridinium substituted by a (hydroxyimino)methyl group at position 2.		7.0610pyridinium ionantidote to organophosphate poisoning;
antidote to sarin poisoning;
cholinergic drug;
cholinesterase reactivator
ConditionIndicatedRelationship StrengthStudiesTrials
Absence Seizure
[description not available]		02.0610
Seizures
Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.		02.0610
Organophosphorus Poisoning
[description not available]		02.3720
Organophosphate Poisoning
Poisoning due to exposure to ORGANOPHOSPHORUS COMPOUNDS, such as ORGANOPHOSPHATES; ORGANOTHIOPHOSPHATES; and ORGANOTHIOPHOSPHONATES.		02.3720