1-hydroxymethylpyrene profile

## 1-Hydroxymethylpyrene: A Key Intermediate in Environmental Research

1-Hydroxymethylpyrene (1-HMP) is an organic compound with the chemical formula C₁₇H₁₂O. It is a **key intermediate** in the **degradation pathway of pyrene**, a polycyclic aromatic hydrocarbon (PAH) commonly found in the environment.

**Here's why 1-HMP is important for research:**

* **Understanding PAH degradation:** Pyrene and other PAHs are known environmental pollutants, with potential carcinogenic effects. Researching the degradation pathways of these compounds is crucial for understanding how they are broken down in the environment and assessing their risk. 1-HMP is a central molecule in the pyrene degradation process, providing a starting point for further research.
* **Bioremediation potential:** Microorganisms play a significant role in degrading PAHs. Studying 1-HMP can help researchers identify key enzymes involved in the breakdown of these pollutants, potentially leading to development of new bioremediation strategies.
* **Understanding environmental fate:** 1-HMP is a reactive intermediate that can undergo further reactions in the environment. Studying its transformation products and reaction rates helps researchers understand the overall fate of PAHs in different environmental matrices like soil, water, and air.
* **Development of analytical tools:** Researching 1-HMP often involves developing new analytical techniques for its detection and quantification. These tools can then be applied to study other PAHs and their degradation products, providing a better understanding of their distribution and impact in the environment.

**Overall, 1-Hydroxymethylpyrene plays a critical role in understanding the fate and impact of PAHs in the environment. Researching this molecule is essential for developing effective methods for mitigating the risk associated with these pollutants.**

ID Source	ID
PubMed CID	104977
CHEMBL ID	1743299
SCHEMBL ID	505806
MeSH ID	M0180885

Synonym
BIDD:GT0067
1-pyrenemethanol
ccris 6510
1-hydroxymethylpyrene
1-pyrenemethanol, 98%
1-(hydroxymethyl)pyrene
24463-15-8
P1221
pyren-1-ylmethanol
CHEMBL1743299
AKOS005265175
pyrenemethanol
unii-c76ux3eh8m
c76ux3eh8m ,
FT-0638425
1-pyrenylmethanol
(1-pyrenyl)methanol
SCHEMBL505806
1-pyrenylmethanol #
DTXSID90179219
mfcd00029252
J-015537
Q63409878
D71019
A877910
SY052044
(pyren-1-yl)methanol
AS-56721
SB66885
CS-W010357

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	14 (53.85)	18.2507
2000's	4 (15.38)	29.6817
2010's	6 (23.08)	24.3611
2020's	2 (7.69)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	26 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
catechol [no description available]	2.13	1	catechols	allelochemical; genotoxin; plant metabolite
chlorine chloride : A halide anion formed when chlorine picks up an electron to form an an anion.	2.38	2	halide anion; monoatomic chlorine	cofactor; Escherichia coli metabolite; human metabolite
hydroquinone [no description available]	2.13	1	benzenediol; hydroquinones	antioxidant; carcinogenic agent; cofactor; Escherichia coli metabolite; human xenobiotic metabolite; mouse metabolite; skin lightening agent
pentachlorophenol PENTA: structure given in first source	2.11	1	aromatic fungicide; chlorophenol; organochlorine pesticide; pentachlorobenzenes	human xenobiotic metabolite
sulfuric acid sulfuric acid : A sulfur oxoacid that consists of two oxo and two hydroxy groups joined covalently to a central sulfur atom.	7.42	2	sulfur oxoacid	catalyst
benzo(a)pyrene Benzo(a)pyrene: A potent mutagen and carcinogen. It is a public health concern because of its possible effects on industrial workers, as an environmental pollutant, an as a component of tobacco smoke.. benzo[a]pyrene : An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.	2.45	2	ortho- and peri-fused polycyclic arene	carcinogenic agent; mouse metabolite
phenobarbital Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.. phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.	2.39	2	barbiturates	anticonvulsant; drug allergen; excitatory amino acid antagonist; sedative
potassium chloride Potassium Chloride: A white crystal or crystalline powder used in BUFFERS; FERTILIZERS; and EXPLOSIVES. It can be used to replenish ELECTROLYTES and restore WATER-ELECTROLYTE BALANCE in treating HYPOKALEMIA.. potassium chloride : A metal chloride salt with a K(+) counterion.	2.39	2	inorganic chloride; inorganic potassium salt; potassium salt	fertilizer
probenecid Probenecid: The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy.. probenecid : A sulfonamide in which the nitrogen of 4-sulfamoylbenzoic acid is substituted with two propyl groups.	7.05	1	benzoic acids; sulfonamide	uricosuric drug
hydroxyacetylaminofluorene Hydroxyacetylaminofluorene: A N-hydroxylated derivative of 2-ACETYLAMINOFLUORENE that has demonstrated carcinogenic action.	2.01	1	2-acetamidofluorenes
diethylnitrosamine Diethylnitrosamine: A nitrosamine derivative with alkylating, carcinogenic, and mutagenic properties.. N-nitrosodiethylamine : A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom.	1.98	1	nitrosamine	carcinogenic agent; hepatotoxic agent; mutagen
hydroxyhydroquinone benzene-1,2,4-triol : A benzenetriol carrying hydroxy groups at positions 1, 2 and 4.	2.13	1	benzenetriol	mouse metabolite
acetylcysteine N-acetyl-L-cysteine : An N-acetyl-L-amino acid that is the N-acetylated derivative of the natural amino acid L-cysteine.	2.03	1	acetylcysteine; L-cysteine derivative; N-acetyl-L-amino acid	antidote to paracetamol poisoning; antiinfective agent; antioxidant; antiviral drug; ferroptosis inhibitor; geroprotector; human metabolite; mucolytic; radical scavenger; vulnerary
1-methylpyrene [no description available]	3.58	8	pyrenes
6-(hydroxymethyl)benzo(a)pyrene 6-(hydroxymethyl)benzo(a)pyrene: RN given refers to parent cpd	1.98	1
9-hydroxymethylanthracene 9-hydroxymethylanthracene: structure given in first source	2.39	2
1-sulfooxymethylpyrene 1-sulfooxymethylpyrene: metabolite of 1-methylpyrene; structure given in first source	7.96	4
aflatoxin b1 Aflatoxin B1: A potent hepatotoxic and hepatocarcinogenic mycotoxin produced by the Aspergillus flavus group of fungi. It is also mutagenic, teratogenic, and causes immunosuppression in animals. It is found as a contaminant in peanuts, cottonseed meal, corn, and other grains. The mycotoxin requires epoxidation to aflatoxin B1 2,3-oxide for activation. Microsomal monooxygenases biotransform the toxin to the less toxic metabolites aflatoxin M1 and Q1.. aflatoxin B1 : An aflatoxin having a tetrahydrocyclopenta[c]furo[3',2':4,5]furo[2,3-h]chromene skeleton with oxygen functionality at positions 1, 4 and 11.	2.25	1	aflatoxin; aromatic ether; aromatic ketone	carcinogenic agent; human metabolite
nadp [no description available]	1.98	1
deoxyguanosine [no description available]	2.1	1	purine 2'-deoxyribonucleoside; purines 2'-deoxy-D-ribonucleoside	Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
phosphorus radioisotopes Phosphorus Radioisotopes: Unstable isotopes of phosphorus that decay or disintegrate emitting radiation. P atoms with atomic weights 28-34 except 31 are radioactive phosphorus isotopes.	1.98	1

Condition	Relationship Strength	Studies
Chromosome-Defective Micronuclei [description not available]	2.69	2
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	2.1	1
Cell Transformation, Neoplastic Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.	1.98	1
Experimental Hepatoma [description not available]	1.98	1
Condition, Preneoplastic [description not available]	1.98	1
Precancerous Conditions Pathological conditions that tend eventually to become malignant.	1.98	1
Cancer of Liver [description not available]	1.98	1
Liver Neoplasms Tumors or cancer of the LIVER.	1.98	1
Fibroadenoma An adenoma containing fibrous tissue. It should be differentiated from ADENOFIBROMA which is a tumor composed of connective tissue (fibroma) containing glandular (adeno-) structures. (From Dorland, 27th ed)	1.99	1
Sarcoma, Epithelioid [description not available]	1.99	1
Sarcoma A connective tissue neoplasm formed by proliferation of mesodermal cells; it is usually highly malignant.	1.99	1
Cancer of Skin [description not available]	2.38	2
Skin Neoplasms Tumors or cancer of the SKIN.	2.38	2

1-hydroxymethylpyrene

Cross-References

Synonyms (30)

Research

Studies (26)

Market Indicators

Research Demand Index: 11.32

Study Types