Page last updated: 2024-12-06
1-hydroxy-3-methylcholanthrene
Description
1-hydroxy-3-methylcholanthrene (3-MC) is a potent polycyclic aromatic hydrocarbon (PAH) that is commonly used in research as a model compound for studying the carcinogenic effects of PAHs. It is a potent inducer of cytochrome P450 1A1 (CYP1A1), a key enzyme involved in the metabolism of PAHs and other xenobiotics. 3-MC is also a potent mutagen and has been shown to induce tumors in a variety of animal models. It is often used in studies investigating the mechanisms of PAH-induced carcinogenesis, as well as the development of new strategies for preventing or treating PAH-related cancers. 3-MC is synthesized from a precursor called 3-methylcholanthrene (3-MC) by enzymatic hydroxylation. 3-MC is produced by the incomplete combustion of organic matter, such as coal, wood, and tobacco. It is also found in contaminated soil and water. 3-MC can enter the body through inhalation, ingestion, or skin contact.'
1-hydroxy-3-methylcholanthrene: RN given refers to cpd without isomeric designation [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
| ID Source | ID |
|---|
| PubMed CID | 18759 |
| SCHEMBL ID | 15992274 |
| MeSH ID | M0078019 |
Synonyms (19)
| Synonym |
|---|
| 1-cholanthrenol, 3-methyl- |
| benz[j]aceanthrylen-1-ol, 1,2-dihydro-3-methyl- |
| 1-hydroxy-3-methylcholanthrene |
| 3-methylcholanthren-1-ol |
| benz(j)aceanthrylen-1-ol, 1,2-dihydro-3-methyl- |
| brn 2293568 |
| 15-hydroxy-20-methylcholanthrene |
| ccris 1080 |
| 1,2-dihydro-3-methylbenz(j)aceanthrylen- 1-ol |
| 3342-98-1 |
| unii-h9b09o30bc |
| h9b09o30bc , |
| SCHEMBL15992274 |
| CHNZFZQGTXDBFI-UHFFFAOYSA-N |
| 3-methyl-1,2-dihydrobenzo[j]aceanthrylen-1-ol # |
| 1-hydroxy-3-methylcholanthrene, (+/-)- |
| 3-methyl-1,2-dihydrocyclopenta[ij]tetraphen-1-ol |
| Q27279796 |
| DTXSID70955038 |
Research
Studies (5)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|
| pre-1990 | 1 (20.00) | 18.7374 |
| 1990's | 3 (60.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Market Indicators
Research Demand Index: 12.87
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| Metric | This Compound (vs All) |
|---|
| Research Demand Index | 12.87 (24.57) | | Research Supply Index | 1.79 (2.92) | | Research Growth Index | 4.66 (4.65) | | Search Engine Demand Index | 0.00 (26.88) | | Search Engine Supply Index | 0.00 (0.95) |
| |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 5 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |