1-hydroxy-3-chloroacetone profile

1-hydroxy-3-chloroacetone (HCA) is a chemical compound with the formula ClCH2COCH2OH. It is a colorless liquid with a pungent odor and is soluble in water.

**Importance in Research:**

HCA is a versatile chemical with a variety of applications in research, including:

* **Synthesis of other compounds:** HCA serves as a valuable building block for the synthesis of various organic compounds, such as pharmaceuticals, pesticides, and polymers.

* **Pharmacological studies:** HCA has been investigated for its potential pharmacological properties, including anti-inflammatory, antimicrobial, and anticancer activities.

* **Environmental research:** HCA is a component of some industrial emissions and has been studied for its environmental impact.

* **Materials science:** HCA has potential applications in the development of new materials, such as adhesives and coatings.

**Specific Examples of Research Applications:**

* **Synthesis of α-chloro ketones:** HCA is a key intermediate in the synthesis of α-chloro ketones, which are useful in the production of pharmaceuticals and agrochemicals.

* **Study of protein modifications:** HCA can modify proteins by reacting with their cysteine residues. This property has been used in research to investigate protein structure and function.

* **Development of novel anticancer agents:** HCA derivatives have shown promise as anticancer agents in preclinical studies.

**Safety Considerations:**

HCA is a potentially hazardous chemical. It is corrosive and can cause skin and eye irritation. Proper handling and safety precautions are essential when working with this compound.

**Conclusion:**

1-hydroxy-3-chloroacetone (HCA) is a valuable chemical with diverse applications in research. Its versatility as a building block, its pharmacological properties, and its role in environmental and materials science make it a significant compound for ongoing scientific investigations.

1-hydroxy-3-chloroacetone: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	90494
SCHEMBL ID	353991
MeSH ID	M0088527

Synonym
24423-98-1
einecs 246-239-6
1-hydroxy-3-chloroacetone
AKOS006386104
1-chloro-3-hydroxypropan-2-one
qu742j268w ,
unii-qu742j268w
2-propanone, 1-chloro-3-hydroxy-
1-chloro-3-hydroxyacetone
2-propanone,1-chloro-3-hydroxy-
3-chloro-1-hydroxyacetone
1-chloro-3-hydroxy-2-propanone
SCHEMBL353991
1-chloro-3-hydroxy-propan-2-one
1-chloro-3-hydroxypropanone
JWZYQAITGQPZNM-UHFFFAOYSA-N
DTXSID90179178
l-chloro-3-hydroxypropanone
Q27287495

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	4 (40.00)	18.7374
1990's	3 (30.00)	18.2507
2000's	3 (30.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	11 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
acetone methyl ketone : A ketone of formula RC(=O)CH3 (R =/= H).	3.68	10	ketone body; methyl ketone; propanones; volatile organic compound	EC 3.5.1.4 (amidase) inhibitor; human metabolite; polar aprotic solvent
lactic acid Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed). 2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.	2.68	3	2-hydroxy monocarboxylic acid	algal metabolite; Daphnia magna metabolite
dihydroxyacetone phosphate Dihydroxyacetone Phosphate: An important intermediate in lipid biosynthesis and in glycolysis.. dihydroxyacetone phosphate : A member of the class of glycerone phosphates that consists of glycerone bearing a single phospho substituent.	2.68	3	glycerone phosphates; primary alpha-hydroxy ketone	Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
glycerol Moon: The natural satellite of the planet Earth. It includes the lunar cycles or phases, the lunar month, lunar landscapes, geography, and soil.	2.38	2	alditol; triol	algal metabolite; detergent; Escherichia coli metabolite; geroprotector; human metabolite; mouse metabolite; osmolyte; Saccharomyces cerevisiae metabolite; solvent
alpha-glycerophosphoric acid [no description available]	1.99	1	glycerol monophosphate	algal metabolite; human metabolite
alpha-chlorohydrin alpha-Chlorohydrin: A chlorinated PROPANEDIOL with antifertility activity in males used as a chemosterilant in rodents.. 3-chloropropane-1,2-diol : A chloropropane-1,2-diol that is propane-1,2-diol substituted by a chloro group at position 3.	3.08	5	chloropropane-1,2-diol
3-chloro-1-propanol 3-chloro-1-propanol: an inhibitor of triosephosphate isomerase and glyceraldehyde 3-phosphate dehydrogenase	2.69	3
chlorine Chlorine: An element with atomic symbol Cl, atomic number 17, and atomic weight 35, and member of the halogen family.	1.96	1	diatomic chlorine; gas molecular entity	bleaching agent
ornidazole Ornidazole: A nitroimidazole antiprotozoal agent used in ameba and trichomonas infections. It is partially plasma-bound and also has radiation-sensitizing action.. ornidazole : A C-nitro compound that is 5-nitroimidazole in which the hydrogens at positions 1 and 2 are replaced by 3-chloro-2-hydroxypropyl and methyl groups, respectively. It is used in the treatment of susceptible protozoal infections and for the treatment of anaerobic bacterial infections.	2	1	C-nitro compound; imidazoles; organochlorine compound; secondary alcohol	antiamoebic agent; antibacterial drug; antiinfective agent; antiprotozoal drug; antitrichomonal drug; epitope
fructose-6-phosphate fructose-6-phosphate: RN given refers to parent cpd with unspecified isomeric designation. fructose 6-phosphate : A ketohexose monophosphate consisting of fructose having a phosphate group located at the 6-position.	2.39	2	D-fructose 6-phosphate
deoxyglucose Deoxyglucose: 2-Deoxy-D-arabino-hexose. An antimetabolite of glucose with antiviral activity.. deoxyglucose : A deoxyhexose comprising glucose having at least one hydroxy group replaced by hydrogen.	1.96	1
3-chlorolactaldehyde 3-chlorolactaldehyde: RN given refers to cpd without isomeric designation	2.37	2
glyceraldehyde 3-phosphate Glyceraldehyde 3-Phosphate: An aldotriose which is an important intermediate in glycolysis and in tryptophan biosynthesis.. glyceraldehyde 3-phosphate : An aldotriose phosphate that is the 3-phospho derivative of glyceraldehyde. It is an important metabolic intermediate in several central metabolic pathways in all organisms.	1.99	1	glyceraldehyde 3-phosphate	mouse metabolite
D-fructopyranose [no description available]	2.67	3	cyclic hemiketal; D-fructose; fructopyranose	sweetening agent
1,6-dichloro-1,6-dideoxyfructose [no description available]	2.01	1
bromopyruvate [no description available]	2.01	1	2-oxo monocarboxylic acid anion
6-chloro-6-deoxyglucose [no description available]	1.96	1
fructose-1,6-diphosphate fructose-1,6-diphosphate: RN refers to (D)-isomer	1.99	1

Condition	Relationship Strength	Studies
Carcinoma, Ehrlich Tumor A transplantable, poorly differentiated malignant tumor which appeared originally as a spontaneous breast carcinoma in a mouse. It grows in both solid and ascitic forms.	1.95	1
Leukemia L 1210 [description not available]	1.95	1
Experimental Neoplasms [description not available]	1.95	1

1-hydroxy-3-chloroacetone

Description

Cross-References

Synonyms (19)

Research

Studies (10)

Market Indicators

Research Demand Index: 11.76

Study Types