Page last updated: 2024-12-07

1-deoxygluco-heptulose 2-phosphate

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

1-deoxygluco-heptulose 2-phosphate (DHP) is a sugar phosphate that plays a key role in the **Calvin cycle** of photosynthesis, specifically in the **reduction of carbon dioxide**.

Here's a breakdown of its significance:

**What it is:**

* DHP is a seven-carbon sugar phosphate, meaning it contains a phosphate group attached to a seven-carbon sugar molecule.
* It's a crucial intermediate in the Calvin cycle, a series of biochemical reactions that convert carbon dioxide into glucose in plants.

**Why it's important for research:**

* **Understanding photosynthesis:** DHP is a key player in one of the most fundamental processes on Earth. Studying its role helps us understand how plants convert light energy into chemical energy, which is essential for life.
* **Developing new technologies:** DHP and its associated enzymes are being explored for potential applications in biotechnology, such as:
* **Engineering new pathways for carbon fixation:** Modifying the Calvin cycle to increase the efficiency of carbon dioxide conversion into biomass could have implications for biofuel production and climate change mitigation.
* **Developing new biocatalysts:** The enzymes involved in DHP metabolism could be used as biocatalysts for various industrial processes.
* **Studying metabolic regulation:** DHP's role in the Calvin cycle highlights the complexity of metabolic regulation in plants. Researching how its levels are controlled can provide insights into plant growth and development.
* **Potential therapeutic applications:** DHP and its derivatives are being investigated for potential therapeutic applications in various diseases, including cancer and diabetes.

**Research Focus:**

Current research on DHP focuses on:

* **Understanding the mechanism of its formation and its role in the Calvin cycle.**
* **Identifying the enzymes involved in its metabolism and their regulatory mechanisms.**
* **Exploring its potential applications in biotechnology and medicine.**

Overall, DHP is a fascinating molecule that holds immense potential for advancing our understanding of photosynthesis, developing new technologies, and improving human health.

1-deoxygluco-heptulose 2-phosphate: RN & structure given in first source; RN not in Chemline 3/85 [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID124823
SCHEMBL ID4312544
MeSH IDM0130034

Synonyms (16)

Synonym
H2P ,
heptulose-2-phosphate
6GPB ,
DB04195
[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)-2-methyloxan-2-yl] dihydrogen phosphate
92642-58-5
SCHEMBL4312544
1-deoxygluco-heptulose 2-phosphate
heptulose-2-p
heptulose 2-phosphate
alpha-d-gluco-2-heptulopyranose, 1-deoxy-, 2-(dihydrogen phosphate)
1-deoxy-d-gluco-heptulose 2-phosphate
1-deoxy-2-o-phosphono-alpha-d-gluco-hept-2-ulopyranose
DTXSID70919034
1-deoxy-2-o-phosphonohept-2-ulopyranose
Q27095022
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Chain A, GLYCOGEN PHOSPHORYLASE BOryctolagus cuniculus (rabbit)Ki14.000014.000014.000014.0000AID977610
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (2)

Assay IDTitleYearJournalArticle
AID1811Experimentally measured binding affinity data derived from PDB1990Journal of molecular biology, Feb-05, Volume: 211, Issue:3
Refined crystal structure of the phosphorylase-heptulose 2-phosphate-oligosaccharide-AMP complex.
AID977610Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB1990Journal of molecular biology, Feb-05, Volume: 211, Issue:3
Refined crystal structure of the phosphorylase-heptulose 2-phosphate-oligosaccharide-AMP complex.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19903 (60.00)18.7374
1990's2 (40.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.60

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.60 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.39 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.60)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]