Page last updated: 2024-12-10
1-deoxyfructose
Description
1-deoxyfructose is a sugar molecule that is closely related to fructose, but with one crucial difference: it lacks an oxygen atom at the 1-position. This lack of oxygen makes 1-deoxyfructose a **deoxy sugar**, a category of sugars that are often used in research for several reasons:
**1. Studying Sugar Metabolism:**
* 1-deoxyfructose is an **inhibitor** of certain enzymes involved in fructose metabolism. By blocking these enzymes, researchers can study the effects of fructose on various metabolic pathways.
* This inhibition can help understand the role of fructose in conditions like diabetes, obesity, and metabolic syndrome.
**2. Exploring Biological Activity:**
* 1-deoxyfructose can act as a **probe** for studying the interactions of sugars with proteins. Its structural similarity to fructose allows it to bind to fructose-binding sites on proteins, but its altered structure can reveal valuable information about the binding process.
**3. Investigating Potential Therapeutic Applications:**
* 1-deoxyfructose has shown potential as an **anti-inflammatory agent** in some studies. This suggests it could be useful in treating inflammatory diseases.
* Its unique properties are being explored for potential applications in drug delivery and other therapeutic areas.
**4. Synthetic Chemistry and Sugar Modifications:**
* 1-deoxyfructose is a useful starting material for synthesizing other modified sugars. These modified sugars can be used in a wide range of research applications, from drug discovery to material science.
**In summary:**
1-deoxyfructose is a valuable research tool that provides insight into sugar metabolism, protein interactions, potential therapeutic applications, and the synthesis of novel sugar derivatives. Its unique structure and biological activity make it an important molecule for advancing our understanding of sugar chemistry and its role in various biological processes.
1-deoxyfructose: RN given refers to (D)-isomer [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
Synonyms (10)
| Synonym |
|---|
| d-fructose, 1-deoxy- |
| 32785-92-5 |
| 1-deoxy-d-fructose |
| 1-deoxyfructose |
| (3s,4r,5r)-3,4,5,6-tetrahydroxyhexan-2-one |
| CHEBI:194162 |
| SCHEMBL183857 |
| deoxyglucosone |
| DTXSID60186450 |
| CHEMBL4572811 |
Drug Classes (1)
| Class | Description |
|---|
| organic molecular entity | Any molecular entity that contains carbon. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] |
Research
Studies (5)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|
| pre-1990 | 2 (40.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 5 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |