Page last updated: 2024-12-06

1-cyclopropylmethyl-4-phenyl-6-methoxy-2(1h)-quinazolinone

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

The compound you're asking about, **1-cyclopropylmethyl-4-phenyl-6-methoxy-2(1H)-quinazolinone**, is a **quinazolinone derivative**. Quinazolinones are a class of heterocyclic compounds that have attracted significant attention in medicinal chemistry due to their diverse biological activities.

Here's a breakdown of the compound and its potential importance:

**Structure:**

* **Quinazolinone core:** The fundamental structure is a bicyclic ring system containing two nitrogen atoms.
* **Substituents:** This specific compound has various substituents attached to the quinazolinone core:
* **1-cyclopropylmethyl:** A cyclopropylmethyl group attached at the nitrogen at position 1.
* **4-phenyl:** A phenyl group attached at position 4.
* **6-methoxy:** A methoxy group attached at position 6.

**Why it might be important for research:**

* **Potential biological activity:** Quinazolinones are known for their potential in various pharmacological areas, including:
* **Anti-cancer activity:** Some quinazolinones have shown promising anti-tumor activity against various cancer cell lines.
* **Anti-inflammatory activity:** They have been investigated for their potential to inhibit inflammation.
* **Anti-microbial activity:** Certain quinazolinones exhibit antimicrobial properties against bacteria and fungi.
* **Central nervous system activity:** They have been studied for their potential effects on the central nervous system, including anxiolytic (anti-anxiety) and anticonvulsant properties.

**Importance in research:**

1. **Lead compound development:** This compound might serve as a starting point for the development of new drugs. Researchers could modify its structure through various synthetic approaches to enhance its desired biological activity or improve its pharmacological properties (e.g., bioavailability, target specificity).

2. **Structure-activity relationship (SAR) studies:** By synthesizing and testing derivatives of this compound with different substituents, researchers can study how the structural modifications affect its biological activity. This knowledge can guide the design of even more potent and selective drug candidates.

3. **Mechanism of action studies:** Investigating how this compound interacts with specific biological targets (e.g., enzymes, receptors) can help understand its mode of action and potentially lead to the development of drugs with more specific therapeutic effects.

**Important Note:** It's crucial to remember that just because this compound belongs to a class of molecules known for their potential therapeutic uses, it doesn't automatically mean it's a promising drug candidate. Further research is necessary to determine its specific biological activity, safety profile, and potential therapeutic value.

Cross-References

ID SourceID
PubMed CID36489
CHEMBL ID2107569
SCHEMBL ID287449
MeSH IDM0058920

Synonyms (24)

Synonym
ciproquazone [inn]
sl 573
1-(cyclopropylmethyl)-6-methoxy-4-phenyl-2(1h)-quinazolinone
2(1h)-quinazolinone, 1-(cyclopropylmethyl)-6-methoxy-4-phenyl-
ciproquazonum [inn-latin]
brn 0761592
ciproquazona [inn-spanish]
OPREA1_210716
sl-573
ciproquazone
1-(cyclopropylmethyl)-6-methoxy-4-phenylquinazolin-2-one
CHEMBL2107569
33453-23-5
unii-p8s0ge5q4i
p8s0ge5q4i ,
ciproquazona
ciproquazonum
1-cyclopropylmethyl-4-phenyl-6-methoxy-2(1h)-quinazolinone
ciproquazone [jan]
1-cyclopropylmethyl-6-methoxy-4-phenyl-2(1h)quinazolinone
SCHEMBL287449
VAFNJIFAZJWWNI-UHFFFAOYSA-N
DTXSID40187102
Q27286381
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19905 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.66

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.66 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.45 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.66)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]