Page last updated: 2024-12-06
1-chloropyrene
Description
1-Chloropyrene is a polycyclic aromatic hydrocarbon (PAH) with a chlorine atom attached at the 1-position of the pyrene molecule. It is a persistent organic pollutant that has been found in various environmental matrices, including soil, water, and air. The synthesis of 1-chloropyrene can be achieved through chlorination of pyrene using a chlorinating agent such as chlorine gas or N-chlorosuccinimide. 1-Chloropyrene has been shown to exhibit various biological effects, including cytotoxicity, genotoxicity, and carcinogenicity. Its importance lies in its potential health risks to humans and the environment due to its persistence and bioaccumulation. Research on 1-chloropyrene focuses on its environmental fate, transport, and toxicological properties. Understanding these aspects is crucial for assessing its potential impact on human health and ecosystems.'
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1-chloropyrene: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
| ID Source | ID |
|---|
| PubMed CID | 36730 |
| SCHEMBL ID | 176331 |
| MeSH ID | M0120192 |
Synonyms (17)
| Synonym |
|---|
| 1-chloropyrene |
| pyrene, 1-chloro- |
| nsc-33062 |
| nsc33062 |
| 34244-14-9 |
| nsc 33062 |
| ccris 5545 |
| brn 1875844 |
| 3-chloropyrene |
| AKOS003620471 |
| unii-ecz7ruy70m |
| ecz7ruy70m , |
| FT-0607657 |
| SCHEMBL176331 |
| WNYHOOQHJMHHQW-UHFFFAOYSA-N |
| mfcd00014327 |
| DTXSID70187817 |
Research Excerpts
Toxicity
| Excerpt | Reference | Relevance |
|---|
| " Cytotoxicity as assessed by the classic 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and neutral red assays showed a mild toxic effect in response to single or multiple dose exposure for up to 72 h, except for multiple dose exposure to BaA and 7-ClBaA (1 μM/d for 4 d) and single exposure to 10 μM BaA." | ( Integration of cellular and molecular endpoints to assess the toxicity of polycyclic aromatic hydrocarbons in HepG2 cell line.
Cardoso, AS; Jordao, L; Jose, S; M Antunes, AM; Morgado, PI; Wanke, R, 2017) | 0.46 |
Research
Studies (7)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|
| pre-1990 | 1 (14.29) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 4 (57.14) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Market Indicators
Research Demand Index: 12.95
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| Metric | This Compound (vs All) |
|---|
| Research Demand Index | 12.95 (24.57) | | Research Supply Index | 2.08 (2.92) | | Research Growth Index | 5.03 (4.65) | | Search Engine Demand Index | 0.00 (26.88) | | Search Engine Supply Index | 0.00 (0.95) |
| |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 7 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |