Compounds > 1-chloro-2-propanol
Page last updated: 2024-12-06

1-chloro-2-propanol

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

## 1-Chloro-2-propanol: A Versatile Building Block

1-Chloro-2-propanol, also known as **2-hydroxy-1-chloropropane**, is an organic compound with the molecular formula **C₃H₇ClO**. It's a colorless liquid with a pungent odor, and its structure features a **chlorine atom attached to the first carbon and a hydroxyl group attached to the second carbon of a propanol backbone**.

**Why is it important for research?**

1-Chloro-2-propanol has found various applications in research due to its versatility as a **building block for synthesizing a range of organic compounds.** Here are some key reasons:

* **Chiral Center:** The presence of a chiral center (the second carbon) makes it a valuable starting material for synthesizing enantiomerically pure compounds. This is particularly relevant in pharmaceutical research, where enantiomers can have different biological effects.
* **Reactivity:** The chloro group makes it reactive towards nucleophiles, allowing for the formation of a variety of functional groups. This opens possibilities for creating diverse organic molecules with desired properties.
* **Precursor to Other Compounds:** 1-Chloro-2-propanol can be used as a precursor to synthesize various important compounds such as:
* **Propane-1,2-diol:** An important industrial solvent and precursor to other chemicals.
* **2-Hydroxypropanoic acid (lactic acid):** A compound vital in various industries, including food, cosmetics, and pharmaceuticals.
* **Other chiral intermediates:** Used in the synthesis of pharmaceuticals, pesticides, and agrochemicals.

**Applications in Research:**

* **Drug discovery:** As a chiral building block, it is used in the synthesis of new drug candidates and exploring their biological activity.
* **Materials science:** Its reactivity allows for the development of novel polymers, coatings, and other materials with specific properties.
* **Organic synthesis:** 1-Chloro-2-propanol is a valuable tool for developing new synthetic methods and exploring the reactivity of various organic molecules.

**Safety Considerations:**

1-Chloro-2-propanol is a **flammable and irritant compound**. Proper safety precautions should be taken when handling it, including:

* Wearing appropriate personal protective equipment (gloves, lab coat, safety goggles).
* Working in a well-ventilated area.
* Handling the compound in a fume hood.
* Storing it in a cool, dry, and well-ventilated place.

**Overall, 1-Chloro-2-propanol is a versatile compound that plays a crucial role in various research areas.** Its reactivity, chirality, and ability to serve as a precursor to other valuable compounds make it a valuable tool for scientists and researchers working in a wide range of disciplines.

1-chloro-2-propanol: RN given refers to cpd without isomeric designation [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

1-chloropropan-2-ol : A secondary alcohol that is isopropanol in which one of the methyl hydrogen atoms is substituted by chlorine. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID31370
CHEMBL ID1361129
CHEBI ID76260
MeSH IDM0065251

Synonyms (68)

Synonym
1-chloropropan-2-ol
1-chloro-2-propanol, technical grade (~75% 1-chloro-2-propanol; ~25% 2-chloro-1-propanol)
brn 0773653
hsdb 1341
1-chloro-2-hydroxypropane
ccris 4766
1-cloro-2-propanol, technical
nsc 77373
einecs 204-819-6
nsc77373
2-propanol, 1-chloro-
1-chloro-2-propanol
chloroisopropyl alcohol
nsc-77373
1-chloroisopropyl alcohol
.alpha.-propylene chlorohydrin
sec-propylene chlorohydrin
propene chlorohydrin
127-00-4
NCGC00091542-01
1-chloro-2-propanol, 70%
NCGC00091542-02
FT-0650633
FT-0650632
A4223
NCGC00091542-03
AKOS005720868
zl0fus96ww ,
unii-zl0fus96ww
dsstox_gsid_21988
dsstox_rid_76444
NCGC00258551-01
dsstox_cid_285
tox21_200998
BBL011446
einecs 269-076-2
68187-16-6
einecs 269-078-3
68187-18-8
68187-19-9
STL146557
einecs 268-361-9
68081-94-7
FT-0607605
CHEMBL1361129
sec-propylene chlorohydrin [hsdb]
sec-propylene chlorohydrin [mi]
1-chloro-2-propanol, (+/-)-
propylchlorohydrin
CHEBI:76260 ,
chloroisopropanol
3-chloropropan-2-ol
3-chloro-2-propanol
1-chloro2-propanol
DTXSID5020285
J-005452
mfcd00004530
1 -chloro-2-propanol
dbedibasicester
C3533
Q161602
H11611
(+/-)-1-chloro-2-propanol; 1-chloro-2-hydroxypropane; 1-chloroisopropyl alcohol; nsc 77373; sec-propylene chlorohydrin; ?-propylene chlorohydrin
SB44665
SB83796
SY110717
EN300-39011
chloropropanol, propylene chlorohydrin

Research Excerpts

Dosage Studied

ExcerptRelevanceReference
" Rats dosed orally with 10, 31 and 100 mg/kg/day for 5 days displayed no significant difference in mean body weight gain or mean mitotic index when compared to controls, however, a dose-response increase (significant) in the number of aberrations, mostly chromatid breaks, was observed in each case."( Mutagenicity of chloropropanol in a genetic screening battery.
Biles, RW; Piper, CE, )		0.13
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (2)

ClassDescription
organochlorine compoundAn organochlorine compound is a compound containing at least one carbon-chlorine bond.
secondary alcoholA secondary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has two other carbon atoms attached to it.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (5)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
interleukin 8Homo sapiens (human)Potency74.97800.047349.480674.9780AID651758
aldehyde dehydrogenase 1 family, member A1Homo sapiens (human)Potency39.81070.011212.4002100.0000AID1030
thyroid stimulating hormone receptorHomo sapiens (human)Potency6.30960.001318.074339.8107AID926; AID938
thyroid hormone receptor beta isoform aHomo sapiens (human)Potency0.31620.010039.53711,122.0200AID588547
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency54.48270.000627.21521,122.0200AID651741
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (9)

TimeframeStudies, This Drug (%)All Drugs %
pre-19904 (44.44)18.7374
1990's2 (22.22)18.2507
2000's0 (0.00)29.6817
2010's3 (33.33)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 38.52

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index38.52 (24.57)
Research Supply Index2.40 (2.92)
Research Growth Index4.21 (4.65)
Search Engine Demand Index49.00 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (38.52)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (10.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other9 (90.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
ether
Ether: A mobile, very volatile, highly flammable liquid used as an inhalation anesthetic and as a solvent for waxes, fats, oils, perfumes, alkaloids, and gums. It is mildly irritating to skin and mucous membranes.. ether : An organooxygen compound with formula ROR, where R is not hydrogen.. diethyl ether : An ether in which the oxygen atom is linked to two ethyl groups.		1.9810ether;
volatile organic compound		inhalation anaesthetic;
non-polar solvent;
refrigerant
triamterene
Triamterene: A pteridinetriamine compound that inhibits SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS.. triamterene : Pteridine substituted at positions 2, 4 and 7 with amino groups and at position 6 with a phenyl group. A sodium channel blocker, it is used as a diuretic in the treatment of hypertension and oedema.		2.1310pteridinesdiuretic;
sodium channel blocker
urethane
[no description available]		1.9810carbamate esterfungal metabolite;
mutagen
propane
Propane: A three carbon alkane with the formula H3CCH2CH3.		2.420alkane;
gas molecular entity		food propellant
vinyl chloride
Vinyl Chloride: A gas that has been used as an aerosol propellant and is the starting material for polyvinyl resins. Toxicity studies have shown various adverse effects, particularly the occurrence of liver neoplasms.. chloroethene : A monohaloethene that is ethene in which one of the hydrogens has been replaced by a chloro group.		1.9810chloroethenes;
gas molecular entity;
monohaloethene		carcinogenic agent
propylene dichloride
propylene dichloride: Russian drug; structure. 1,2-dichloropropane : A chloroalkane that is propane in which a hydrogen from each of two adjacent carbons has been replaced by chlorines.		1.9510chloroalkane;
volatile organic compound
2-chloro-1-propanol
[no description available]		3.5120
1-amino-2,4-dibromoanthraquinone
1-amino-2,4-dibromoanthraquinone: intermediate in the production of dyes		2.1310anthraquinone
isatin
tribulin: endogenous MONOAMINE OXIDASE inhibitory activity extractable into ethyl acetate found in brain and many mammalian tissues and fluids; ISATIN is a major component; produced in excess following alcohol withdrawal;		1.9810indoledioneEC 1.4.3.4 (monoamine oxidase) inhibitor;
plant metabolite
1,2,3-trichloropropane
[no description available]		2.1310organochlorine compound
bis(2-chloroethyl)ether
bis(2-chloroethyl)ether: structure		1.9810ether
1-chloro-2-methylpropene
[no description available]		1.9810organochlorine compound
bis(chloromethyl) ether
Bis(Chloromethyl) Ether: A substance that is an irritant to the eyes and respiratory tract and may be carcinogenic.. bis(chloromethyl) ether : An ether that is dimethyl ether in which one of the hydrogens attached to each of the methyl group has replaced by a chlorine.		1.9510ether;
organochlorine compound		alkylating agent;
carcinogenic agent
acetylcysteine
N-acetyl-L-cysteine : An N-acetyl-L-amino acid that is the N-acetylated derivative of the natural amino acid L-cysteine.		1.9510acetylcysteine;
L-cysteine derivative;
N-acetyl-L-amino acid		antidote to paracetamol poisoning;
antiinfective agent;
antioxidant;
antiviral drug;
ferroptosis inhibitor;
geroprotector;
human metabolite;
mucolytic;
radical scavenger;
vulnerary
hempa
Hempa: A chemosterilant agent that is anticipated to be a carcinogen.		1.9810phosphoramideinsect sterilant;
mutagen
dimethyl methylphosphonate
[no description available]		1.9810
dimethylol dihydroxyethyleneurea
dimethylol dihydroxyethyleneurea: used in cotton or cotton-polyester blend fabric		1.9810
1,4-bis(2,3-epoxypropoxy)butane
[no description available]		1.9810
isopropyl glycidyl ether
isopropyl glycidyl ether: RN & structure given in first source		1.9810
carboxin
Carboxin: A systemic agricultural fungicide and seed treatment agent.. carboxin : An anilide obtained by formal condensation of the amino group of aniline with the carboxy group of 2-methyl-5,6-dihydro-1,4-oxathiine-3-carboxylic acid. A fungicide for control of bunts and smuts that is normally used as a seed treatment.		2.1310anilide fungicide;
anilide;
enamide;
organosulfur heterocyclic compound;
oxacycle;
secondary carboxamide		antifungal agrochemical;
EC 1.3.5.1 [succinate dehydrogenase (quinone)] inhibitor
silver
Silver: An element with the atomic symbol Ag, atomic number 47, and atomic weight 107.87. It is a soft metal that is used medically in surgical instruments, dental prostheses, and alloys. Long-continued use of silver salts can lead to a form of poisoning known as ARGYRIA.		2.0610copper group element atom;
elemental silver		Escherichia coli metabolite
2,3-dioxo-5-indolinesulfonic acid
2,3-dioxo-5-indolinesulfonic acid: reagent for modification of tryptophan residues in peptides & proteins		1.9810
s-(3-hydroxypropyl)cysteine n-acetate
[no description available]		1.9510N-acyl-L-amino acid
nitrofurantoin
Nitrofurantoin: A urinary anti-infective agent effective against most gram-positive and gram-negative organisms. Although sulfonamides and antibiotics are usually the agents of choice for urinary tract infections, nitrofurantoin is widely used for prophylaxis and long-term suppression.. nitrofurantoin : An imidazolidine-2,4-dione that is hydantoin substituted at position 1 by a [(5-nitro-2-furyl)methylene]amino group. An antibiotic that damages bacterial DNA.		2.1310imidazolidine-2,4-dione;
nitrofuran antibiotic;
organonitrogen heterocyclic antibiotic;
organooxygen heterocyclic antibiotic		antibacterial drug;
antiinfective agent;
hepatotoxic agent
n,o-bis(trimethylsilyl)trifluoroacetamide
[no description available]		2.1510
ConditionIndicatedRelationship StrengthStudiesTrials
Body Weight
The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.		02.4420
Chromosomal Translocation
[description not available]		01.9810
Birth Weight
The mass or quantity of heaviness of an individual at BIRTH. It is expressed by units of pounds or kilograms.		01.9910
Pregnancy
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.		01.9910