Page last updated: 2024-12-08
1-azidonaphthalene-5-sulfonate
1-Azidonaphthalene-5-sulfonate (ANS) is a fluorescent probe that is commonly used in research to study a variety of biological processes. It is a small, hydrophobic molecule that can bind to a variety of proteins and other biological molecules. This binding can change the fluorescence properties of ANS, allowing researchers to use it to study things like:
* **Protein folding and structure:** ANS binds to hydrophobic regions of proteins, and its fluorescence changes depending on the environment of the binding site. This can be used to study how proteins fold and unfold, and how they interact with other molecules.
* **Membrane dynamics:** ANS can bind to lipid membranes, and its fluorescence is sensitive to changes in membrane fluidity and organization. This allows researchers to study how membranes change in response to different stimuli.
* **Enzyme activity:** ANS can be used to study the activity of certain enzymes. For example, it can bind to the active site of some enzymes, inhibiting their activity and causing a change in its fluorescence.
* **Cellular processes:** ANS can be used to study a variety of cellular processes, such as cell growth, cell death, and cell signaling.
**Why is it important for research?**
ANS is a valuable tool for research because it is:
* **Versatile:** It can be used to study a wide variety of biological processes.
* **Sensitive:** It is very sensitive to changes in its environment, making it a good indicator of changes in protein structure, membrane fluidity, or enzyme activity.
* **Non-invasive:** ANS does not significantly interfere with the biological processes it is used to study.
**Limitations of ANS:**
* **Specificity:** ANS can bind to a variety of molecules, so it is not always specific to the target of interest.
* **Photobleaching:** ANS is susceptible to photobleaching, which can limit its use in long-term experiments.
**Overall, 1-azidonaphthalene-5-sulfonate (ANS) is a valuable tool for researchers studying a variety of biological processes. Its versatility, sensitivity, and non-invasive nature make it a powerful tool for understanding the complex world of cells and molecules.**
Cross-References
ID Source | ID |
PubMed CID | 189782 |
MeSH ID | M0079715 |
Synonyms (7)
Synonym |
anms |
1-naphthalenesulfonic acid, 5-azido- |
73105-93-8 |
5-azidonaphthalene-1-sulfonic acid |
5-azido-1-naphthalenesulfonate |
1-azidonaphthalene-5-sulfonate |
DTXSID10993858 |
Research
Studies (12)
Timeframe | Studies, This Drug (%) | All Drugs % |
pre-1990 | 1 (8.33) | 18.7374 |
1990's | 1 (8.33) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 10 (83.33) | 2.80 |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Market Indicators
Research Demand Index: 11.74
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
Metric | This Compound (vs All) |
---|
Research Demand Index | 11.74 (24.57) | Research Supply Index | 2.71 (2.92) | Research Growth Index | 4.45 (4.65) | Search Engine Demand Index | 0.00 (26.88) | Search Engine Supply Index | 0.00 (0.95) |
| |
Study Types
Publication Type | This drug (%) | All Drugs (%) |
Trials | 1 (7.69%) | 5.53% |
Reviews | 1 (7.69%) | 6.00% |
Case Studies | 0 (0.00%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 11 (84.62%) | 84.16% |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |