1-arachidonyl monoglyceride profile

## 1-Arachidonyl Monoglyceride (1-AG): A Key Player in Endocannabinoid Signaling

**1-Arachidonyl monoglyceride (1-AG)** is a **lipid molecule** that serves as an **endocannabinoid**, meaning it's produced naturally in the body and acts as a neurotransmitter within the endocannabinoid system.

**Why is it important for research?**

1-AG plays a crucial role in various physiological processes, making it a fascinating subject of research. Here are some key reasons:

* **Neurotransmitter**: 1-AG is a potent activator of **cannabinoid receptor type 1 (CB1)**, which is primarily located in the central nervous system. This interaction modulates neurotransmission, influencing processes like:
* **Pain perception**: 1-AG contributes to the analgesic effects of the endocannabinoid system, playing a role in pain relief.
* **Mood regulation**: Its interaction with CB1 receptors is linked to anti-anxiety and antidepressant effects.
* **Memory and learning**: Studies suggest 1-AG might contribute to memory formation and retrieval.
* **Appetite**: 1-AG promotes feelings of satiety, contributing to appetite control.
* **Anti-inflammatory**: 1-AG exerts anti-inflammatory effects by interacting with CB1 and other receptors involved in inflammation, potentially offering therapeutic potential for inflammatory diseases.
* **Neuroprotective**: 1-AG exhibits neuroprotective properties, reducing neuronal damage caused by oxidative stress and excitotoxicity. This aspect is being explored for treating neurodegenerative diseases like Alzheimer's and Parkinson's.
* **Metabolic regulation**: 1-AG influences glucose metabolism, impacting insulin sensitivity and lipid metabolism. This could have implications for conditions like diabetes and obesity.

**Research Implications:**

Understanding the intricate workings of 1-AG and its interactions within the endocannabinoid system is vital for:

* **Developing new therapeutic strategies**: Researchers are exploring 1-AG-based medications for treating various conditions, including chronic pain, anxiety, depression, and neurodegenerative diseases.
* **Unraveling the complexities of the endocannabinoid system**: Studying 1-AG sheds light on the intricate signaling pathways and molecular mechanisms involved in the endocannabinoid system, furthering our understanding of this vital regulatory network.
* **Developing novel drug targets**: Identifying the precise mechanisms by which 1-AG exerts its effects can lead to the development of new drug targets for manipulating the endocannabinoid system for therapeutic benefits.

**In summary, 1-AG is a multifaceted molecule with significant implications for research. Its crucial role in neurotransmission, inflammation, neuroprotection, and metabolism makes it an important target for developing new therapies and understanding the intricate workings of the endocannabinoid system.**

1-arachidonyl monoglyceride: causes platelet aggregation [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	5282281
CHEMBL ID	354786
CHEBI ID	75612
SCHEMBL ID	2119943
MeSH ID	M0086812

Synonym
glyceryl arachidonate
chebi:75612 ,
CHEMBL354786
2,3-dihydroxypropyl (5z,8z,11z,14z)-icosa-5,8,11,14-tetraenoate
SCHEMBL2119943
5,8,11,14-eicosatetraenoic acid, 2,3-dihydroxypropyl ester-
arachidonic acid, monoester with 1,2,3-propanetriol
2,3-dihydroxypropyl 5,8,11,14-eicosatetraenoate
5,8,11,14-eicosatetraenoic acid, 2,3-dihydroxypropyl ester, (all-z)-
35474-99-8
glyceryl monoarachidonate
6uxx4lrj92 ,
1-arachidonyl monoglyceride
unii-6uxx4lrj92
1-(5z,8z,11z,14z-eicosatetraenoyl)-glycerol
5,8,11,14-eicosatetraenoic acid 2,3-dihydroxypropyl ester
1-monoarachidin
glyceryl 1-arachidonate
1-monoarachidonoyl-rac-glycerol
5,8,11,14-eicosatetraenoic acid, 2,3-dihydroxypropyl ester, (5z,8z,11z,14z)-
(all-z)-(+/-)-2,3-dihydroxypropyl 5,8,11,14-eicosatetraenoate
5z,8z,11z,14z-eicosatetraenoic acid, 1-glyceryl ester
DCPCOKIYJYGMDN-DOFZRALJSA-N
HMS3649A21
Q27891183
sr-01000946554
SR-01000946554-1
DTXSID501019093
BP-29892

Class	Description
1-acylglycerol 20:4	A 1-monoglyceride in which the acyl group contains 20 carbons and 4 double bonds.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Assay ID	Title	Year	Journal	Article
AID38685	Tested for hydrolysis by rat brain microsomal anandamide amidohydrolase (AAH).	1999	Journal of medicinal chemistry, Mar-11, Volume: 42, Issue:5	Substrate specificity and stereoselectivity of rat brain microsomal anandamide amidohydrolase.
AID38682	Tested for hydrolysis by rat brain microsomal anandamide amidohydrolase (AAH).	1999	Journal of medicinal chemistry, Mar-11, Volume: 42, Issue:5	Substrate specificity and stereoselectivity of rat brain microsomal anandamide amidohydrolase.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	2 (20.00)	18.7374
1990's	2 (20.00)	18.2507
2000's	3 (30.00)	29.6817
2010's	2 (20.00)	24.3611
2020's	1 (10.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (10.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	9 (90.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
am 251 AM 251: an analog of SR141716A; structure given in first source. AM-251 : A carbohydrazide obtained by formal condensation of the carboxy group of 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid with the amino group of 1-aminopiperidine. An antagonist at the CB1 cannabinoid receptor.	2.06	1	amidopiperidine; carbohydrazide; dichlorobenzene; organoiodine compound; pyrazoles	antidepressant; antineoplastic agent; apoptosis inducer; CB1 receptor antagonist
aspirin Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5). acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.. acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.	1.95	1	benzoic acids; phenyl acetates; salicylates	anticoagulant; antipyretic; cyclooxygenase 1 inhibitor; cyclooxygenase 2 inhibitor; drug allergen; EC 1.1.1.188 (prostaglandin-F synthase) inhibitor; geroprotector; non-narcotic analgesic; non-steroidal anti-inflammatory drug; plant activator; platelet aggregation inhibitor; prostaglandin antagonist; teratogenic agent
ethidium Ethidium: A trypanocidal agent and possible antiviral agent that is widely used in experimental cell biology and biochemistry. Ethidium has several experimentally useful properties including binding to nucleic acids, noncompetitive inhibition of nicotinic acetylcholine receptors, and fluorescence among others. It is most commonly used as the bromide.. ethidium : The fluorescent compound widely used in experimental cell biology and biochemistry to reveal double-stranded DNA and RNA.	2.02	1	phenanthridines	fluorochrome; intercalator
indomethacin Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.. indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.	1.95	1	aromatic ether; indole-3-acetic acids; monochlorobenzenes; N-acylindole	analgesic; drug metabolite; EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor; environmental contaminant; gout suppressant; non-steroidal anti-inflammatory drug; xenobiotic metabolite; xenobiotic
palmidrol palmidrol: a cannabinoid receptor-inactive eCB-related molecule used as prophylactic in helping to prevent respiratory viral infection. palmitoyl ethanolamide : An N-(long-chain-acyl)ethanolamine that is the ethanolamide of palmitic (hexadecanoic) acid.	2.21	1	endocannabinoid; N-(long-chain-acyl)ethanolamine; N-(saturated fatty acyl)ethanolamine	anti-inflammatory drug; anticonvulsant; antihypertensive agent; neuroprotective agent
edetic acid Edetic Acid: A chelating agent that sequesters a variety of polyvalent cations such as CALCIUM. It is used in pharmaceutical manufacturing and as a food additive.	2.21	1	ethylenediamine derivative; polyamino carboxylic acid; tetracarboxylic acid	anticoagulant; antidote; chelator; copper chelator; geroprotector
dronabinol Dronabinol: A psychoactive compound extracted from the resin of Cannabis sativa (marihuana, hashish). The isomer delta-9-tetrahydrocannabinol (THC) is considered the most active form, producing characteristic mood and perceptual changes associated with this compound.. Delta(9)-tetrahydrocannabinol : A diterpenoid that is 6a,7,8,10a-tetrahydro-6H-benzo[c]chromene substituted at position 1 by a hydroxy group, positions 6, 6 and 9 by methyl groups and at position 3 by a pentyl group. The principal psychoactive constituent of the cannabis plant, it is used for treatment of anorexia associated with AIDS as well as nausea and vomiting associated with cancer chemotherapy.	1.99	1	benzochromene; diterpenoid; phytocannabinoid; polyketide	cannabinoid receptor agonist; epitope; hallucinogen; metabolite; non-narcotic analgesic
stearoylethanolamide N-(octadecanoyl)ethanolamine : An N-acylethanolamine 18:0 that is the ethanolamide of octadecanoic acid.	2	1	N-acylethanolamine 18:0
sr141716 [no description available]	2.42	2	amidopiperidine; carbohydrazide; dichlorobenzene; monochlorobenzenes; pyrazoles	anti-obesity agent; appetite depressant; CB1 receptor antagonist
dihydroethidium dihydroethidium: RN given is for the (+-)-isomer	2.02	1
arachidonic acid icosa-5,8,11,14-tetraenoic acid : Any icosatetraenoic acid with the double bonds at positions 5, 8, 11 and 14.. arachidonate : A long-chain fatty acid anion resulting from the removal of a proton from the carboxy group of arachidonic acid.	2.43	2	icosa-5,8,11,14-tetraenoic acid; long-chain fatty acid; omega-6 fatty acid	Daphnia galeata metabolite; EC 3.1.1.1 (carboxylesterase) inhibitor; human metabolite; mouse metabolite
isopropyl thiogalactoside Isopropyl Thiogalactoside: A non-metabolizable galactose analog that induces expression of the LAC OPERON.. isopropyl beta-D-thiogalactopyranoside : An S-glycosyl compound consisting of beta-D-1-thiogalactose having an isopropyl group attached to the anomeric sulfur.	2.02	1	S-glycosyl compound
dinoprostone prostaglandin E2 : Prostaglandin F2alpha in which the hydroxy group at position 9 has been oxidised to the corresponding ketone. Prostaglandin E2 is the most common and most biologically potent of mammalian prostaglandins.	2.02	1	prostaglandins E	human metabolite; mouse metabolite; oxytocic
anandamide anandamide : An N-acylethanolamine 20:4 resulting from the formal condensation of carboxy group of arachidonic acid with the amino group of ethanolamine.	2.72	3	endocannabinoid; N-acylethanolamine 20:4	human blood serum metabolite; neurotransmitter; vasodilator agent
glyceryl 2-arachidonate glyceryl 2-arachidonate: binds to cannabinoid receptors; structure in first source. 2-arachidonoylglycerol : An endocannabinoid and an endogenous agonist of the cannabinoid receptors (CB1 and CB2). It is an ester formed from omega-6-arachidonic acid and glycerol.	2.78	3	2-acylglycerol 20:4; endocannabinoid	human metabolite
arachidonoyl amine arachidonoyl amine : A primary fatty amide resulting from the formal condensation of the carboxy group of arachidonic acid with ammonia.	2	1	primary fatty amide	cannabinoid receptor agonist
linoleoyl ethanolamide linoleoyl ethanolamide: RN given for (Z,Z)-isomer. linoleoyl ethanolamide : An N-acylethanolamine 18:2 that is the ethanolamide of linoleic acid.	2	1	N-acylethanolamine 18:2	EC 3.5.1.99 (fatty acid amide hydrolase) inhibitor
n-oleoylethanolamine N-oleoylethanolamine: ceramidase inhibitor. oleoyl ethanolamide : An N-(long-chain-acyl)ethanolamine that is the ethanolamide of oleic acid. The monounsaturated analogue of the endocannabinoid anandamide.	2.45	2	endocannabinoid; N-(long-chain-acyl)ethanolamine; N-acylethanolamine 18:1	EC 3.5.1.23 (ceramidase) inhibitor; geroprotector; PPARalpha agonist
1-monooleoyl-rac-glycerol Peceol: lipid excipient containing readily dispersible mixture of mono- & diglycerides of oleic acid. 1-oleoylglycerol : A 1-monoglyceride where the acyl group is oleoyl.. monooleoylglycerol : A monoglyceride in which the acyl group is oleoyl with the position of acylation unspecified.	1.95	1	1-acylglycerol 18:1; monooleoylglycerol	plant metabolite
imolamine [no description available]	2.02	1
am-356 methanandamide: structure given in first source; RN given refers to (all-Z)-(+-)-isomer	2	1	fatty amide
am 404 [no description available]	2	1	anilide
phosphatidylcholines Phosphatidylcholines: Derivatives of PHOSPHATIDIC ACIDS in which the phosphoric acid is bound in ester linkage to a CHOLINE moiety.	2.38	2	1,2-diacyl-sn-glycero-3-phosphocholine
piperidines Piperidines: A family of hexahydropyridines.	2.42	2
alpha-(4-pyridyl-1-oxide)-n-tert-butylnitrone alpha-(4-pyridyl-1-oxide)-N-tert-butylnitrone: structure given in first source	2.02	1

Condition	Relationship Strength	Studies
Brain Swelling [description not available]	2.95	1
Acute Brain Injuries [description not available]	2.95	1
Brain Edema Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular fluid) is indicative of a disturbance in cell metabolism, and is commonly associated with hypoxic or ischemic injuries (see HYPOXIA, BRAIN). An increase in extracellular fluid may be caused by increased brain capillary permeability (vasogenic edema), an osmotic gradient, local blockages in interstitial fluid pathways, or by obstruction of CSF flow (e.g., obstructive HYDROCEPHALUS). (From Childs Nerv Syst 1992 Sep; 8(6):301-6)	2.95	1
Brain Injuries Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.	2.95	1
Blood Pressure, Low [description not available]	1.99	1
Hypotension Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DIZZINESS but greater negative impacts on the body occur when there is prolonged depravation of oxygen and nutrients.	1.99	1

1-arachidonyl monoglyceride

Description

Cross-References

Synonyms (29)

Drug Classes (1)

Bioassays (2)

Research

Studies (10)

Market Indicators

Research Demand Index: 12.27

Study Types