Compounds > 1-aminopropanediol
Page last updated: 2024-12-06

1-aminopropanediol

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

1-Aminopropanediol, also known as 3-amino-1,2-propanediol, is a colorless, viscous liquid that is used as a precursor in the synthesis of pharmaceuticals, including the antimalarial drug mefloquine. It is also a component of some cosmetics and personal care products. The compound is a chiral molecule, meaning it exists in two mirror-image forms, called enantiomers. Only the (S)-enantiomer of 1-aminopropanediol is pharmacologically active. It is synthesized through the reaction of 1,2-epoxypropane with ammonia. 1-Aminopropanediol is studied due to its biological activity as a potent inhibitor of the enzyme glycogen synthase kinase-3 (GSK-3). GSK-3 is involved in a variety of cellular processes, including the regulation of glucose metabolism, cell growth, and inflammation. Inhibition of GSK-3 has been implicated in the treatment of various diseases, including Alzheimer's disease, type 2 diabetes, and cancer.'

1-aminopropanediol: structure given in first source; RN given refers to parent cpd [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID73561
MeSH IDM0175034

Synonyms (79)

Synonym
4-04-00-01865 (beilstein handbook reference)
unii-rh369p864x
rh369p864x ,
ec 210-475-8
1-aminoglycerol
2,3-dihydroxypropylamine
wln: z1yq1q
nsc-67381
1-amino-2,3-propanediol
2,3-propandiol-1-amine
nsc67381
3-amino-1,2-propanediol
616-30-8
1,2-propanediol, 3-amino-
einecs 210-475-8
brn 1719121
nsc 67381
1-aminopropanediol
ai3-11002
3-aminopropane-1,2-diol
(+/-)-3-amino-1,2-propanediol, 97%
AB258BA4-8B6E-4939-A773-6152376CFD23
(+/-)-3-amino-1,2-propandiol
A0628
3-aminopropan-1,2-diol
A19738
AKOS005259373
3-amino-1,2-propandiol
1-amino-2,3-dihydroxypropane
FT-0641054
BP-12973
FT-0601135
FT-0601390
AM20100501
CL4509
(+/-)-3-amino-1,2-propanediol
(+/-)-3-amino-1,2-dihydroxypropane
isoserinol
(rs)-3-amino-1,2-propanediol
aminopropanediol [inci]
3-amino-2-hydroxypropanol
racemic-3-amino-1,2-propanediol
1-aminopropane-2,3-diol
3-amino-propan-1,2-diol
3-amino propane 1,2-diol
amino-2,3-propanediol
(2rs)-3-amino-1,2-propanediol
3-amino-1,2-propane-diol
1-amino-2,3-propane diol
3-amino-l,2-propandiol
n-(2,3-dihydroxy-propyl)-amine
racemic 1-amino-2,3-propanediol
racemic 3-aminopropane-1,2-diol
aminopropan-2,3-diol
2,3-dihydroxy-propylamine
3-amino1,2-propanediol
3-amino-propane-1,2-diol
(+/-) 3-amino-1,2-propanediol
(r/s)-3-aminopropane-1,2-diol
3-amino-1,2-dihydroxypropane
(rs)-3-amino-1,2-propandiol
racemic 3-amino-1,2-propanediol
(+/-)-3-aminopropane-1,2-diol
2,3-dihydroxy-1-propylamine
(+/-)3-amino-1,2-propanediol
1-amino-2,3-propandiol
J-502215
Q-200353
STR01210
AC-23129
mfcd00008140
CS-W002040
(a+/-)-3-amino-1,2-propanediol
BCP18703
DTXSID30862294
EN300-50845
Q27288116
SB44646
SB44645
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's2 (40.00)18.2507
2000's1 (20.00)29.6817
2010's0 (0.00)24.3611
2020's2 (40.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.95

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.95 (24.57)
Research Supply Index2.30 (2.92)
Research Growth Index4.25 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.95)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other9 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
choline
[no description available]		2.4110cholinesallergen;
Daphnia magna metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
neurotransmitter;
nutrient;
plant metabolite;
Saccharomyces cerevisiae metabolite
glycerol
Moon: The natural satellite of the planet Earth. It includes the lunar cycles or phases, the lunar month, lunar landscapes, geography, and soil.		2.0210alditol;
triol		algal metabolite;
detergent;
Escherichia coli metabolite;
geroprotector;
human metabolite;
mouse metabolite;
osmolyte;
Saccharomyces cerevisiae metabolite;
solvent
propylene glycol
Propylene Glycol: A clear, colorless, viscous organic solvent and diluent used in pharmaceutical preparations.. propane-1,2-diol : The simplest member of the class of propane-1,2-diols, consisting of propane in which a hydrogen at position 1 and a hydrogen at position 2 are substituted by hydroxy groups. A colourless, viscous, hygroscopic, low-melting (-59degreeC) and high-boiling (188degreeC) liquid with low toxicity, it is used as a solvent, emulsifying agent, and antifreeze.		2.4110glycol;
propane-1,2-diols		allergen;
human xenobiotic metabolite;
mouse metabolite;
protic solvent
phosphatidylcholines
Phosphatidylcholines: Derivatives of PHOSPHATIDIC ACIDS in which the phosphoric acid is bound in ester linkage to a CHOLINE moiety.		1.97101,2-diacyl-sn-glycero-3-phosphocholine
ConditionIndicatedRelationship StrengthStudiesTrials